G-130
From Wikipedia, the free encyclopedia
This article is about the stimulant drug. For the glycoprotein, see Gp130.
 |
|
|---|---|
| Systematic (IUPAC) name | |
| 2-phenyl-5,5-dimethylmorpholine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 42013-48-9  |
| ATC code | ? |
| PubChem | CID 97711 |
| ChemSpider | 88190 |
| Chemical data | |
| Formula | C12H17NO |
| Mol. mass | 191.269 g/mol |
|
|
|
|
 (what is this?) (verify) |
|
G-130 (GP-130, 2-Phenyl-5,5-dimethyltetrahydro-1,4-oxazine)[1] is a drug with stimulant and anorectic effects, related to phenmetrazine.[2][3][4]
[edit] Structural analogs
Compounds related to G 130 and radafaxine were synthesized that behave as combined inhibitors of monoamine uptake and nAChRs.[5]
[edit] See also
- 2-Phenyl-3,6-dimethylmorpholine
- Phendimetrazine (2-Phenyl-3,4-dimethylmorpholine)
- Manifaxine
- Radafaxine
[edit] References
- ^ GB 1336732 - Diethanolamine Derivatives.
- ^ Fanelli O (June 1973). "Pharmacological and toxicological study of a new psychotropic stimulant: the 2-phenyl-5-dimethyl-tetrahydro-1,4-oxazine, in comparison with d,l-amphetamine, phenmetrazine and pemoline-Mg". Arzneimittel-Forschung 23 (6): 810–6. PMID 4740767.
- ^ Fanelli O, Mazzoncini V, Ferri S (October 1974). "Toxicological and teratological study of 2-phenyl-5,5-dimethyl-tetrahydro-1,4-oxazine hydrochloride (G 130), a psychostimulant drug". Arzneimittel-Forschung 24 (10): 1627–32. PMID 4479774.
- ^ Fanelli O, Mazzoncini V, Trallori L (December 1974). "Antagonism of psychostimulant 2-phenyl-5,5-dimethyl-tetrahydro-1,4-oxazine hydrochloride (G 130) to central nervous system depressing drugs. Monoamine oxidase inhibitory activity and norepinephrine and serotonin induced changes. Comparison with dL-amphetamine". Arzneimittel-Forschung 24 (12): 2025–9. PMID 4480283.
- ^ Carroll, F. Ivy; Muresan, Ana Z.; Blough, Bruce E.; Navarro, Hernán A.; Mascarella, S. Wayne; Eaton, J. Brek; Huang, Xiaodong; Damaj, M. Imad et al. (2011). "Synthesis of 2-(Substituted Phenyl)-3,5,5-trimethylmorpholine Analogues and Their Effects on Monoamine Uptake, Nicotinic Acetylcholine Receptor Function, and Behavioral Effects of Nicotine". Journal of Medicinal Chemistry 54 (5): 1441–1448. doi:10.1021/jm1014555. PMID 21319801.
 |
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |
