(–)-2β-Carbomethoxy-3β-(4-tolyl)tropane (RTI-32, tolpane) is a phenyltropane-based cocaine analog that is important in the field of medicinal chemistry for performing SAR.
It has similar properties in vitro to related drugs such as RTI-31.[1]
Whereas the potency of RTI-31 has been quoted as being as high as 64 x cocaine, RTI-32 is not anything like this strong.
Comparison of Data
Compound |
DAT |
DA |
NET |
NA |
SERT |
5HT |
ED50 |
Troparil |
23 |
49.8 |
550 |
37.2 |
178 |
173 |
0.34 |
RTI-32 |
1.7 |
7.02 |
36 |
8.42 |
23 |
19.4 |
0.31 |
RTI-31 |
1.1 |
3.68 |
22 |
5.86 |
4.0 |
5.0 |
0.13 |
3'4'-xylyl |
0.43 |
unknown |
44 |
unknown |
2.42 |
unknown |
[edit] See also
[edit] References
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2-Carboxymethyl Esters |
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(3,4-Disubstituted Phenyl)-tropanes |
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Arylcarboxy |
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Carboxyalkyl |
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Acyl |
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β,α Stereochemistry |
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α,β Stereochemistry |
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Heterocycles: 3-Substituted-isoxazol-5-yl |
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Heterocycles: 3-Substituted-1,2,4-oxadiazole |
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N-alkyl |
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N-replaced (S,O,C) |
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Irreversible |
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Nortropanes (N-demethylated) |
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- Adamantanes: Amantadine
- Memantine
- Rimantadine; Aminotetralins: 7-OH-DPAT
- 8-OH-PBZI
- Rotigotine
- UH-232; Benzazepines: 6-Br-APB
- Fenoldopam
- SKF-38,393
- SKF-77,434
- SKF-81,297
- SKF-82,958
- SKF-83,959; Ergolines: Bromocriptine
- Cabergoline
- Dihydroergocryptine
- Epicriptine
- Lisuride
- LSD
- Pergolide; Dihydrexidine derivatives: 2-OH-NPA
- A-86,929
- Ciladopa
- Dihydrexidine
- Dinapsoline
- Dinoxyline
- Doxanthrine; Others: A-68,930
- A-77636
- A-412,997
- ABT-670
- ABT-724
- Aplindore
- Apomorphine
- Aripiprazole
- Bifeprunox
- BP-897
- CY-208,243
- Dizocilpine
- Etilevodopa
- Flibanserin
- Ketamine
- Melevodopa
- Modafinil
- Pardoprunox
- Phencyclidine
- PD-128,907
- PD-168,077
- PF-219,061
- Piribedil
- Pramipexole
- Propylnorapomorphine
- Pukateine
- Quinagolide
- Quinelorane
- Quinpirole
- RDS-127
- Ro10-5824
- Ropinirole
- Rotigotine
- Roxindole
- Salvinorin A
- SKF-89,145
- Sumanirole
- Terguride
- Umespirone
- WAY-100,635
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