Dopastin
From Wikipedia, the free encyclopedia
| Dopastin | |
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(2E)-N-{(2S)-2-[Hydroxy(nitroso)amino]-3-methylbutyl}-2-butenamide |
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| Identifiers | |
| CAS number | 37134-80-8 |
| PubChem | 6434226 |
| ChemSpider | 4939169 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C9H17N3O3 |
| Molar mass | 215.25 g mol−1 |
| Melting point |
116-119 °C[1] |
| Acidity (pKa) | 5.1[1] |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Dopastin is a chemical compound produced by the bacteria Pseudomonas No. BAC-125.[2] It was first isolated and characterized in 1972. It is an inhibitor of the enzyme dopamine β-hydroxylase.[3]
Dopastin can be prepared synthetically from L-valinol.[4]
[edit] References
- ^ a b Merck Index, 11th Edition, 3417
- ^ Iimura, H; Takeuchi, T; Kondo, S; Matsuzaki, M; Umezawa, H (1972). "Dopastin, an inhibitor of dopamine -hydroxylase". The Journal of antibiotics 25 (8): 497–500. PMID 4648494.
- ^ H. Iinuma; M. Matsuzaki; T. Nagatsu; T. Takeuchi; H. Umezawa (1974). "Biochemical and biological studies on dopastin, an inhibitor of dopamine β-hydroxylase". Agric. Biol. Chem. 38 (11): 2107–2111. doi:10.1271/bbb1961.38.2107.
- ^ Ohno, M.; Iinuma, H.; Yagisawa, N.; Shibahara, S.; Suhara, Y.; Kondo, S.; Maeda, K.; Umezawa, H. (1973). "Synthesis of dopastin, a dopamine ?-hydroxylase inhibitor of microbial origin". Journal of the Chemical Society, Chemical Communications (4): 147. doi:10.1039/C39730000147.
