FZD10

FZD10
Identifiers
Aliases	FZD10, CD350, FZ-10, Fz10, FzE7, hFz10, frizzled class receptor 10
External IDs	MGI: 2136761 HomoloGene: 21411 GeneCards: FZD10
Gene ontology Molecular function • signal transducer activity • protein binding • Wnt-activated receptor activity • transmembrane signaling receptor activity • G-protein coupled receptor activity • Wnt-protein binding Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • cell surface • nucleoplasm Biological process • cellular response to retinoic acid • G-protein coupled receptor signaling pathway • regulation of actin cytoskeleton organization • non-canonical Wnt signaling pathway via JNK cascade • positive regulation of JUN kinase activity • Wnt signaling pathway • multicellular organism development • positive regulation of GTPase activity • cell surface receptor signaling pathway • negative regulation of GTPase activity • neuron differentiation • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11211	93897
Ensembl	ENSG00000111432	ENSMUSG00000081683
UniProt	Q9ULW2	Q8BKG4
RefSeq (mRNA)	NM_007197	NM_175284
RefSeq (protein)	NP_009128	NP_780493.1 NP_780493
Location (UCSC)	Chr 12: 130.16 – 130.17 Mb	Chr 5: 128.6 – 128.6 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Frizzled-10 is a protein that in humans is encoded by the FZD10 gene. FZD10 has also been designated as CD350 (cluster of differentiation 350).

Function

This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.

See also

• Frizzled

Further reading

• Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (Jun 1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proceedings of the National Academy of Sciences of the United States of America. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640. 
• Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (Aug 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proceedings of the National Academy of Sciences of the United States of America. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618. 
• Kumar S, Connor JR, Dodds RA, Halsey W, Van Horn M, Mao J, Sathe G, Mui P, Agarwal P, Badger AM, Lee JC, Gowen M, Lark MW (Oct 2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries". Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society. 9 (7): 641–53. doi:10.1053/joca.2001.0421. PMID 11597177. 
• Terasaki H, Saitoh T, Shiokawa K, Katoh M (Feb 2002). "Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway". International Journal of Molecular Medicine. 9 (2): 107–12. doi:10.3892/ijmm.9.2.107. PMID 11786918. 
• Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. 

External links

• "Frizzled Receptors: FZD₁₀". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• FZD10 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.