CLEC10A

CLEC10A
Identifiers
Aliases	CLEC10A, CD301, CLECSF13, CLECSF14, HML, HML2, MGL, C-type lectin domain family 10 member A
External IDs	MGI: 2385729 HomoloGene: 7836 GeneCards: CLEC10A
Gene ontology Molecular function • carbohydrate binding Cellular component • integral component of membrane • plasma membrane • membrane Biological process • innate immune response • endocytosis • adaptive immune response • immune system process • stimulatory C-type lectin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10462	216864
Ensembl	ENSG00000132514	ENSMUSG00000040950
UniProt	Q8IUN9	n/a
RefSeq (mRNA)	NM_006344 NM_182906 NM_001330070	NM_145137
RefSeq (protein)	NP_001316999 NP_006335 NP_878910	n/a
Location (UCSC)	Chr 17: 7.07 – 7.08 Mb	Chr 11: 70.13 – 70.14 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

C-type lectin domain family 10 member A also known as CLEC10A is a protein that in humans is encoded by the CLEC10A gene.

Function

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene.

External links

• Human CLEC10A genome location and CLEC10A gene details page in the UCSC Genome Browser.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932. 
• van Vliet SJ, Steeghs L, Bruijns SC, et al. (2009). Seifert HS, ed. "Variation of Neisseria gonorrhoeae Lipooligosaccharide Directs Dendritic Cell–Induced T Helper Responses". PLoS Pathog. 5 (10): e1000625. doi:10.1371/journal.ppat.1000625. PMC 2757725 . PMID 19834553. 
• Iijima M, Tomita M, Morozumi S, et al. (2009). "Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP". Neurology. 73 (17): 1348–52. doi:10.1212/WNL.0b013e3181bd1139. PMID 19776380. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.