HIV

The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS). AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.

HIV infects vital cells in the human immune system such as helper T cells (specifically CD4⁺ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4⁺ T cells through a number of mechanisms, including pyroptosis of abortively infected T cells,apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4⁺ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4⁺ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.

Patient zero

Patient zero may refer to:

See also

HIV/AIDS

Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV). Following initial infection, a person may not notice any symptoms or may experience a brief period of influenza-like illness. Typically, this is followed by a prolonged period with no symptoms. As the infection progresses, it interferes more with the immune system, increasing the risk of common infections like tuberculosis, as well as other opportunistic infections, and tumors that rarely affect people who have working immune systems. These late symptoms of infection are referred to as AIDS. This stage is often also associated with weight loss.

HIV is spread primarily by unprotected sex (including anal and oral sex), contaminated blood transfusions, hypodermic needles, and from mother to child during pregnancy, delivery, or breastfeeding. Some bodily fluids, such as saliva and tears, do not transmit HIV. Methods of prevention include safe sex, needle-exchange programs, treating those who are infected, and male circumcision. Disease in a baby can often be prevented by give both the mother and child antiretroviral medication. There is no cure or vaccine; however, antiretroviral treatment can slow the course of the disease and may lead to a near-normal life expectancy. Treatment is recommended as soon as the diagnosis is made. Without treatment, the average survival time after infection is 11 years.

Band Aid 30

Band Aid 30 is the 2014 incarnation of the charity supergroup Band Aid. The group was announced on 10 November 2014 by Bob Geldof and Midge Ure, with Geldof stating that he took the step after the United Nations had contacted him, saying help was urgently needed to prevent the 2014 Ebola crisis in Western Africa spreading throughout the world. As in previous incarnations, the group covered the track "Do They Know It's Christmas?", written in 1984 by Geldof and Ure, this time to raise money towards the Ebola crisis in Western Africa. The track has re-tweaked lyrics to reflect the current Ebola virus epidemic in West Africa with all proceeds going towards battling what Geldof described as a "particularly pernicious illness because it renders humans untouchable and that is sickening".

The song was recorded by some of the biggest-selling current British and Irish pop acts, including One Direction, Sam Smith, Ed Sheeran, Emeli Sandé, Ellie Goulding and Rita Ora. Bastille and Guy Garvey of Mercury prize-winning band Elbow were also on board, along with Chris Martin (Coldplay) and Bono (U2)—the third time he has contributed to a Band Aid recording.

Creative Commons

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