Toxicity

Toxicity is the degree to which a substance can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity). By extension, the word may be metaphorically used to describe toxic effects on larger and more complex groups, such as the family unit or society at large.

A central concept of toxicology is that effects are dose-dependent; even water can lead to water intoxication when taken in too high a dose, whereas for even a very toxic substance such as snake venom there is a dose below which there is no detectable toxic effect. Toxicity is species-specific, making cross-species analysis problematic. Newer paradigms and metrics are evolving to bypass animal testing, while maintaining the concept of toxicity endpoints.

Types of toxicity

There are generally three types of toxic entities; chemical, biological, and physical:

System of a Down

System of a Down, often shortened to SOAD or System, is a four-piece Armenian-American rock band formed in 1994 in Glendale, California, in the United States. The band currently consists of Serj Tankian (lead vocals, keyboards), Daron Malakian (vocals, guitar), Shavo Odadjian (bass, backing vocals) and John Dolmayan (drums).

The band achieved commercial success with the release of five studio albums, three of which debuted at number one on the Billboard 200. System of a Down has been nominated for four Grammy Awards, and their song "B.Y.O.B." won the Best Hard Rock Performance of 2006. The group went on hiatus in August 2006 and reunited in November 2010, embarking on a tour for the following three years. System of a Down has sold over 40 million records worldwide.

History

Soil (1992–1994)

Serj Tankian and Daron Malakian attended Rose and Alex Pilibos Armenian School as children, although due to their eight-year age difference they did not meet until 1992 while working on separate projects at the same recording studio. They formed a band named Soil with Tankian on vocals and keyboards, Malakian on vocals and guitar, Dave Hakopyan (who later played in The Apex Theory/Mt. Helium) on bass and Domingo "Dingo" Laranio on drums. The band hired Shavo Odadjian (another Rose and Alex Pilibos alumnus) as manager, although he eventually joined Soil as rhythm guitarist. In 1994, after only one live show, and one jam session recording, Hakopyan and Laranio left the band, feeling that it was not going anywhere.

System

A system is a set of interacting or interdependent component parts forming a complex/intricate whole. Every system is delineated by its spatial and temporal boundaries, surrounded and influenced by its environment, described by its structure and purpose and expressed in its functioning.

The term system may also refer to a set of rules that governs structure and/or behavior. Alternatively, and usually in the context of complex social systems, the term is used to describe the set of rules that govern structure and/or behavior.

Etymology

The term "system" comes from the Latin word systēma, in turn from Greek σύστημα systēma: "whole compounded of several parts or members, system", literary "composition".

History

According to Marshall McLuhan,

"System" means "something to look at". You must have a very high visual gradient to have systematization. In philosophy, before Descartes, there was no "system". Plato had no "system". Aristotle had no "system".

In the 19th century the French physicist Nicolas Léonard Sadi Carnot, who studied thermodynamics, pioneered the development of the concept of a "system" in the natural sciences. In 1824 he studied the system which he called the working substance (typically a body of water vapor) in steam engines, in regards to the system's ability to do work when heat is applied to it. The working substance could be put in contact with either a boiler, a cold reservoir (a stream of cold water), or a piston (to which the working body could do work by pushing on it). In 1850, the German physicist Rudolf Clausius generalized this picture to include the concept of the surroundings and began to use the term "working body" when referring to the system.

Down

Down may refer to:

Music

Songs

Chop suey

Chop suey (/ˈtʃɒpˈsuːi/; simplified Chinese: 杂碎; traditional Chinese: 雜碎; pinyin: zá suì; literally: "assorted pieces") is a dish in American Chinese cuisine and other forms of overseas Chinese cuisine, consisting of meat (often chicken, fish, beef, prawns, or pork) and eggs, cooked quickly with vegetables such as bean sprouts, cabbage, and celery and bound in a starch-thickened sauce. It is typically served with rice but can become the Chinese-American form of chow mein with the addition of stir-fried noodles.

Chop suey has become a prominent part of American Chinese cuisine, Filipino cuisine, Canadian Chinese cuisine, German Chinese cuisine, Indian Chinese cuisine, and Polynesian cuisine. In Chinese Indonesian cuisine it is known as cap cai (雜菜, "mixed vegetables") and mainly consists of vegetables.

Origins

Chop suey is widely believed to have been invented in America by Chinese Americans, but the anthropologist E.N. Anderson concludes that the dish is based on tsap seui (杂碎, “miscellaneous leftovers”), common in Taishan (Toisan), a county in Guangdong Province (Canton), the home of many early Chinese immigrants to the U.S. This "became the infamous ‘chop suey’ of third-string Chinese restaurants in the western world, but it began life as a good if humble dish among the specialist vegetable farmers of the area. At the end of the day, they would stir-fry the small shoots, thinnings, and unsold vegetables—up to ten species in a dish!" The Hong Kong doctor Li Shu-fan likewise reported that he knew it in Toisan in the 1890s.