ATG may refer to:
Autophagy-related protein 101 also known as ATG101 is a protein that in humans is encoded by the C12orf44 gene (chromosome 12 open reading frame 44).
Autophagy is the process of forming a vacuole around proteins and nucleic acids that are to be broken down in lysosomes. The transcribed mRNA sequence of C12orf44 is 1287 base pairs, and following translation the sequence is 218 amino acids in length. The ATG101 protein is localized in the cytoplasm, but can possibly also be found bound to a structure known as a phagophore, involved in autophagy. The gene is highly conserved among mammals, as well as showing conservation among most eukaryotes. It is thought to directly interact with ATG13 in the ULK1 complex, which may be important for activating phagophores.
ATG101 is a newly found important autophagy related protein, among many other proteins responsible for autophagy, a process well conserved among most eukaryotic organisms. However, ATG101 is not homologous to any of the other ATG proteins. ATG101 interacts with essential autophagy protein ATG13 in mammals, which is a ULK1 interacting protein. ULK1 (unc-51-like kinase 1) is thought to be important to the activation of macroautophagy in mammals. ATG101 is suggested to protect ATG13 from proteasomal degradation, therefore stabilizing levels of ATG13 found in cells and regulating levels of macroautophagy. According to published papers, ATG101 is said to localize to the isolation membrane, also known as a phagophore. This attachment to the phagophore could possibly explain the palmitoylation site found on the third AA, which is a cysteine. Phagophores are responsible for recognizing and surrounding materials that are to be degraded in the lysosome, by forming a membrane that completely surrounds the materials to be degraded.
Autophagy-related protein 7 is a protein that in humans is encoded by the ATG7 gene.
This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vaculuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes.
A company is an association or collection of individuals, whether natural persons, legal persons, or a mixture of both. Company members share a common purpose and unite in order to focus their various talents and organize their collectively available skills or resources to achieve specific, declared goals. Companies take various forms such as:
A company or association of persons can be created at law as legal person so that the company in itself can accept Limited liability for civil responsibility and taxation incurred as members perform (or fail) to discharge their duty within the publicly declared "birth certificate" or published policy.
Because companies are legal persons, they also may associate and register themselves as companies – often known as a corporate group. When the company closes it may need a "death certificate" to avoid further legal obligations.
The Company refers to a fictional covert international organization in the NBC drama Heroes. Its primary purpose is to identify, monitor and study those individuals with genetically-derived special abilities. The Company played a central role in the plot of Volume Two, during the second season of the series. It is a very notable organization in the series and is connected to several of the characters.
In season two, Kaito Nakamura revealed that there were twelve founders of the Company, and a photo of the twelve is later seen (listed below under "Group photo"); it did not include Adam Monroe, an immortal human with the ability of rapid cellular regeneration, who is described as the one who "brought them all together." The Company began sometime between January 1977 and February 14, 1977. Monroe was locked away for thirty years on November 2, 1977, concluding that he only spent about 10 to 11 months with the Company. In the first season of the show, Daniel Linderman heads the Company until his demise. He is substituted in the second season by Bob Bishop, who is implied to be the Company's financial source. However, when Sylar kills him in the beginning of Season 3, Angela Petrelli takes over. Several of the founders have children who are posthumans and who are main characters within the series.
A company is a group of more than one persons to carry out an enterprise and so a form of business organization.
Company may also refer to:
In titles and proper names:
ATG may refer to:
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