- published: 29 Oct 2015
- views: 8174411
Addiction is a state characterized by compulsive engagement in rewarding stimuli, despite adverse consequences. It can be thought of as a disease or biological process leading to such behaviors. The two properties that characterize all addictive stimuli are that they are reinforcing (i.e., they increase the likelihood that a person will seek repeated exposure to them) and intrinsically rewarding (i.e., something perceived as being positive or desirable).
Addiction is a disorder of the brain's reward system which arises through transcriptional and epigenetic mechanisms and occurs over time from chronically high levels of exposure to an addictive stimulus (e.g., morphine, cocaine, sexual intercourse, gambling, etc.).ΔFosB, a gene transcription factor, is a critical component and common factor in the development of virtually all forms of behavioral and drug addictions; two decades of research into ΔFosB's role in addiction have demonstrated that addiction arises, and the associated compulsive behavior intensifies or attenuates, along with the genetic overexpression of ΔFosB in the D1-type medium spiny neurons of the nucleus accumbens; due to the causal relationship between ΔFosB expression and addictions, it is used preclinically as an addiction biomarker. ΔFosB expression in these neurons directly and positively regulates drug self-administration and reward sensitization through positive reinforcement, while decreasing sensitivity to aversion.
Actors: Luke Mitchell (editor), Luke Mitchell (actor), Luke Mitchell (producer), Luke Mitchell (writer), Luke Mitchell (director), Matthew Chowtee (actor), Matthew Chowtee (writer), Matthew Chowtee (producer), Matthew Chowtee (editor), Keilah Griffiths (actress), Ryan Fields (actor), Shane Morris (actor),
Genres: Short, Thriller,Actors: Aaron Pope (actor), Lec Zorn (actor), Rasheda Randle (actress), Sia Harding (actress), Cheri Cofer (actress), Tajuana Butler (director), Tajuana Butler (producer), Tajuana Butler (writer), Robert Jackson (producer), Robert Jackson (actor), Rachel Rose (actress), Lisa Jorman (actress), Nikki Hopkins (actress), Dale Young (actor), Kimberly Coates (actress),
Genres: Drama, Short,Actors: Steven G. Kaplan (producer), Jennifer DeLia (writer), Jennifer DeLia (director), Joséphine de La Baume (actress), Anya Taraboulsy (costume designer), Anton Nadler (producer), James Wirt (actor), Sally Golan (producer), Benjamin Flaherty (editor), Sally Golan (actress), Sally Golan (actress), Bob Juergens (actor), Toni Busker (producer), Margherita Missoni (actress), Christian Strawn (actor),
Genres: Drama, Short,It could bring pain like a ball and chain
Well, this artificial loving got me going insane
She took? to go way too far
But it matters aobut as much as tears in the rain
All I wanted was just one more night
Just one more chance to make it through alright
But she fucked in my mind just like old times
And I knew it was still the same
She's my addiction
Coming around to get me again
Well, you think I know better than to trust a friend
She always gets whatever she wants
And I'll be the one that lost in the end
She got no time to waste on someone like me
She doesn't want the responsibility
But as long as I'm there she might as well
Have another go 'cause she knows
She's my addiction
You would think I'd learn my lesson by now
I'd like to kick this habit but I don't know how
'Cause though I know she'll never want me again
I'd like to think she will somehow
Someday someone will take her place
And I might be able to forget her face
But for now all I have is a memory that I wish I could erase