- published: 06 Oct 2013
- views: 28372
Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are considered to be one of the two traditional classes of ionophoric proteins, with the other class known as ion transporters (including the sodium-potassium pump, sodium-calcium exchanger, and sodium-glucose transport proteins, amongst others).
Study of ion channels (channelomics) often includes biophysics, electrophysiology and pharmacology, utilizing techniques including voltage clamp, patch clamp, immunohistochemistry, X-ray crystallography, fluorescence, and RT-PCR.
There are two distinctive features of ion channels that differentiate them from other types of ion transporter proteins:
This screencast discusses the basic types of ion channels in neurons, models of gating, gating stimuli, and functional states of gated channels.
Chemical-gated and voltage-gated ion channel animation
This video lecture about cell membrane transport explains about the structure and properties of ion channels. It also explains the role of ion channels in facilitated diffusion which is a type of passive transport across the cell membrane. This video lecture also explains about the different types of channels including ion channel linked receptor, Ion channel coupled receptors, ligand gated ion channel, voltage gated ion channels and so on. Ion channels help different irons to transport across the cell membrane. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of li...
http://www.handwrittentutorials.com - This is the second tutorial in a series on Action Potentials. This video looks at how the Voltage Gated Na+ & K+ Ion channels change the voltage across the membrane of a cell and thus produce an action potential. For more entirely FREE tutorials and their accompanying PDFs visit http://www.handwrittentutorials.com
Donate here: http://www.aklectures.com/donate.php Website video link: http://www.aklectures.com/lecture/voltage-gated-ion-channels Facebook link: https://www.facebook.com/aklectures Website link: http://www.aklectures.com
Animation describing the role of ion channel coupled receptors in neurotransmission.
Donate here: http://www.aklectures.com/donate.php Website video: http://www.aklectures.com/lecture/ligand-gated-ion-channels Facebook link: https://www.facebook.com/aklectures Website link: http://www.aklectures.com
Created with Stop Motion Studio. Available for iPhone, iPod and iPad on the AppStore. http://itunes.apple.com/us/app/id441651297?mt=8&at;=10lGyj&ct;=yt
Get your free audiobook or ebook: http://zaxo.space/sabk/35/en/B00P91PVTA/book Volume 33 reviews the current understanding of ion channel regulation by signal transduction pathways. Ion channels are no longer viewed simply as the voltage-gated resistors of biophysicists or the ligand-gated receptors of biochemists. They have been transformed during the past 20 years into signaling proteins that regulate every aspect of cell physiology. In addition to the voltage-gated channels, which provide the ionic currents to generate and spread neuronal activity, and the calcium ions to trigger synaptic transmission, hormonal secretion, and muscle contraction, new gene families of ion channel proteins regulate cell migration, cell cycle progression, apoptosis, and gene transcription, as well as electr...
Get your free audiobook or ebook: http://zaxo.space/sabk/35/en/B00PYZ2VOY/book The Academic Press Factsbooks series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as 'a growing series of excellent manuals' by Molecular Medicine Today, and 'essential works of reference' by Trends in Biochemical Sciences, the Factsbooks have become the most popular comprehensive data resources available. As they are meticulously researched and use an easy-to-follow format, the Factsbooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity.in a set of four interrelated volumes, The Ion Channel Factsbook provides a comprehensive framework of facts about channe...
Get your free audiobook or ebook: http://zaxo.space/sabk/35/en/B015IJDSCE/book This volume describes chemical approaches to assess ion channel structure, function and pharmacology. Topics discussed include the use of engineered ionizable side chains to obtain information on permeation pathways and the local environment; the modification of engineered cysteine side chains, including cysteine scanning mutagenesis and the attachment of fluorescent probes and bio-reactive tethers; and the nascent use of genetic code expansion, evaluating its applications to ion channel and membrane proteins. This comprehensive text provides multifaceted perspectives on the great diversity of state-of-the-art methods which take advantage of the ever-expanding chemical toolbox to study ion channel biology.captur...
Get your free audiobook or ebook: http://zaxo.space/sabk/35/en/B01I2RCNQG/book Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes...
Get your free audiobook or ebook: http://zaxo.space/sabk/35/en/B00S9OM1DI/book The New Benchmark for Understanding the Latest Developments of Ion Channelsion channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of cells. In nonexcitable tissues, they also help regulate basic salt balance critical for homeostasis. All of these features make ion channels important targets for pharmaceuticals. Handbook of Ion Channels illustrates the fundamental importance of these membrane proteins to human health and disease. Renowned researchers from around the world introduce the technical aspect...
We are seeing an increasing trend towards generation and interaction with very large time-varying datasets in scientific simulation. These datasets are used to study the dynamics and evolution of phenomena in a variety of application domains ranging from understanding the evolution of planets and stars to the understanding of life itself. For instance, a cardiologist may be interested in understanding the deformations, strain, and variations of the electric field across a beating heart; a meteorologist may use time-varying atmospheric simulation and observation datasets to validate weather prediction models and study atmospheric instabilities; a biochemist may use molecular dynamics simulations to better understand the relationships between biomacromolecular form and function; an aeronauti...
In this video we discuss voltage gated ion channels. Topics discussed include the action potential, voltage gated potassium channels, calcium activated potassium channels, voltage gated sodium channels and voltage gated calcium channels.
This video looks at the structure and function of ion channels. It considers both active and passive ion channels. The emphasis on ion channels surrounds the neuron membrane. This brief look at the passage of ions across the nerve cell is the beginning of a conversation leading to a discussion of action potentials.
Table of Contents: 00:09 Lecture 2.3: Ion channels 00:16 Week 2: Chemical basis of electrical signals 01:29 Patch clamping 03:15 Recording configurations 05:14 Individual ion channel Na+ currents 06:09 Transient inward current as sum of currents 08:02 Individual ion channel K+ currents 08:37 Delayed outward current as sum of currents 09:03 Diversity of ion channels 10:12 Further diversity of ion channels 11:20 Touch 13:43 Taste 14:33 Spice 16:02 Hearing 18:21 Sight 19:19 Sight This video is part of the nanoHUB-U course "Introduction to Bioelectricity." (http://nanohub.org/courses/bioelec) This course introduces students to The fundamentals of bioelectricity of the mammalian nervous system. Passive and active forms of electric signaling in both intra and inter-cellular communication at th...
Lectured by Jason Matthew Taken from Neuroscience 2: Action Potential
In this video we discuss the Acid-sensing ion channels which are a ligand gated ion channels within the family of P2X-like receptors.
Explains the roles of ion channels in shaping action potentials, the relationship of action potentials to cell functions, summation at synapses, excitation contraction coupling and crosstalk between ion channels through changes in membrane potential and sub-membrane microdomains of calcium ions.
Covers electrophysiology methods used to study ion channels and examples of ion channel diversity. 2:44 Voltage clamp methods 6:29 Patch clamp: an extension of voltage-clamp 9:18 Na+ current voltage dependence 11:13 K+ current voltage dependence 11:38 Types of current recorded 15:46 Rectifying K+ currents 16:42 K+ channel rectification in IV plots 19:11 IUPHAR/BPS Guide to Pharmacology 20:04 Ion channel families 21:00 Ion channel diversity 21:52 Distinct Ca2+ channel currents mediated by different alpha subunits 23:26 Distinct K+ currents mediated by related alpha subunits 24:21 Heteromeric vs. homomeric Kv channels 25:36 Why so many ion channel subtypes?
Introductory Human Physiology:; TRANSPORTERS, CHANNELS & PUMPS Emma Jakoi, Ph.D. Learning objectives: • Describe how solutes cross cell membranes • Explain how charge, size, and solubility affect solute movement across cell membranes. • Contrast how transporters, pumps and channels work • Describe how ion channels are gated. • Explain transcellular transport • Explain osmosis • Explain osmolarity and tonicity • Explain how effective solutes regulate fluid compartments