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- Published: 20 Jul 2010
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- Author: wl12342008
Also, in 2005, the United States Department of Defense funded a study to look into CX717 and the physiological effects of sleepiness. The study found that rhesus monkeys performed faster and better after receiving the drug, and it counteracted the effects of sleep deprivation.
However, a 2006 study funded by DARPA found that CX717 did not improve cognitive performance in humans subjected to simulated night shift work.
In early March 2006 Cortex reported that, in a small pilot Phase II study, CX717 had demonstrated positive clinical and statistical results on the primary endpoint, the ADHD rating scale and the sub-scales related to attention and hyperactivity which are used for the approval of all currently available ADHD treatments. According to a Cortex Pharmaceuticals press release, "Consistent with all previous studies involving over 220 patients and healthy adults, this study demonstrated that CX717 was safe, well tolerated, and produced no increase in heart rate, blood pressure or other cardiovascular side effects".
In April 2007 Cortex Pharmaceuticals submitted two large data packages to the FDA regarding CX717. One data set went to the FDA's Division of Neurology Drug Products for the treatment of Alzheimer's disease, while the other went to the Division of Psychiatry Products where the company filed a second CX717 IND for the treatment of ADHD. According to a Cortex Pharmaceuticals press release, the submitted data package "provides clear evidence that the specific histopathological changes seen in animal toxicology studies, which previously caused the FDA to put CX717 on clinical hold, is a postmortem fixation artifact and is not found in the tissue of the animal when it is still living".
Roger G Stoll PhD, Chief Executive Officer of Cortex, stated,
“When CX717 was removed from clinical hold on October 6, 2006 by the Neurology Division a dose was permitted for continuing a study in patients with Alzheimer's disease, but that dose was too low to permit the assessment of the drug in patients with ADHD. Further information was needed to better understand the cause of the histopathological changes. We now have a substantial data base which clearly documents the fact that the histological changes of concern occur postmortem when the fixative solution is used to prepare the slides of the tissue specimens.”
However, in October 2007 the FDA denied Cortex's IND application for a Phase IIb study of CX717 for treatment of ADHD, based on the same animal toxicology results. Cortex responded by inactivating the application, although it will "continue its plans to develop CX717 for the acute treatment of respiratory depression (RD) and continue its study of CX717 in its Alzheimer’s disease PET scan study. Cortex believes that the IND application previously filed with the Division of Neurology Products of the FDA for the treatment of Alzheimer’s disease will not be affected by the actions of the DPP." The company hopes that after the use of the compound in treating a high-risk acute condition is approved and well-established, the risks of longer-term use at higher doses, such as for treatment of ADHD, will be shown to be less than the FDA had concluded.
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Name | Jay Chou |
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Caption | Chou on the red carpet at the MTV Asia Aid, Bangkok, Thailand, 2005 |
Tradchinesename | 周杰倫 |
Simpchinesename | 周杰伦 |
Pinyinchinesename | Zhōu Jiélún |
Origin | Republic of China (Taiwan) |
Birthdate | January 18, 1979 |
Birthplace | Linkou, Taipei County, Taiwan |
Othername | Director Chou (周董) |
Occupation | Musician, singer-songwriter, composer, record producer, rapper, deejay, music video director, film director, music arranger, model, screenwriter, actor |
Genre | R&B;MandopopTaiwanese popHip popC-rock |
Instrument | Piano, violin, cello, guitar, drum, guzheng, bass guitar, keyboard, pipa, erhu, harmonica |
Label | Sony Music Taiwan(2008–present)JVR Music (2007–present)Alfa Music (1999–2007) |
Yearsactive | 2000–present |
Parents | Father: Zhou Yaozhong (周耀中)Mother: Ye Huimei (葉惠美) |
Influenced | Nan Quan Mama |
Religion | Buddhist |
Website | Jay Chou@JVR Music |
Hongkongfilmwards | Best New Performer2006 Initial DBest Original Film Song2007 "Chrysanthemum Terrace" (Curse of the Golden Flower) |
Goldenhorseawards | Best Newcomer2005 Initial DOutstanding Taiwanese Film of the Year2007 SecretBest Original Song2007 "The Secret That Cannot Be Told" (Secret) |
Mtvasiaawards | Favorite Artist, Taiwan2002, 2005 |
Goldenmelodyawards | Best Mandarin Album2001 Jay2002 Fantasy2004 Ye Hui MeiBest Music Video2009 "Mr. Magic" (Capricorn)Best Song of the Year2008 "Blue and White Porcelain" (On the Run)2009 "Fragrant Rice" (Capricorn)Best Composer2002 "Love Before A.D." (Fantasy)2008 "Blue and White Porcelain" (On the Run)Best Producer2002 Fantasy |
Awards | World Music AwardsBest-Selling Chinese Artist2004, 2006, 2007, 2008Shanghai Film Critics Awards2007 Best Actor (Curse of the Golden Flower) |
In 2000, Chou released his first album, titled Jay, under the record company Alfa Music. Since then he has released one album per year except in 2009, selling several million copies each. His music has gained recognition throughout Asia, most notably in regions such as Taiwan, China, Hong Kong, Japan, Malaysia, Indonesia, India, Singapore, Thailand, Vietnam and in overseas Asian communities, winning more than 20 awards each year. He has sold more than 28 million albums worldwide up to 2010. He debuted his acting career in Initial D (2005), for which he won Best Newcomer Actor in both the Hong Kong Film Awards and the Golden Horse Awards, and was nominated for Best Supporting Actor by Hong Kong Film Awards for his role in Curse of the Golden Flower (2006). He produced the theme song for the film Ocean Heaven starring Jet Li. His career now extends into directing and running his own record company JVR Music.
He regularly fuses traditional Chinese instruments and styles with R&B; or rock to form a new genre called "Zhongguo feng" (), which literally means "Chinese Style Music", some of which are written in the Pentatonic Scale as opposed to the more common seven-note scale (Diatonic Scale) to accentuate an oriental style. Besides his own culture, he also incorporated Spanish guitar in "Red Imitation" (), American techno/electronica in "Herbalist's Manual" (), rap with subtle classical music undertones in "Reverse Scales" (), and Bossanova style in "Rosemary" (), to name a few. Sound effects from everyday life are frequently woven into his music, such as bouncing ping pong balls, touch tone phone dialing, helicopter blades, dripping rain, and radio static noise (concrete music).
His formal musical training is evident by the use of classical textures in his compositions. For example, counterpoint was used in "Perfection" () and "Sorry" (), while polyphony can be found in "The Wound That Ends War" () and "Twilight's Chapter Seven" ().
Chou's albums have been noted for the lack of change compared to his earlier works, yet he firmly stated that he will not alter his style: "They say I've been standing still ... but this is the music I want, and I don't see what I want by moving ahead." which he also insisted will not change; however, recently he has adopted clearer pronunciation for certain songs, particularly more traditional Chinese style songs, such as "Faraway" () which features Fei Yu-ching and "Chrysanthemum Terrace" ().
Chou himself has written lyrics for many ballads, but has also discussed societal ills such as drug addiction in "Coward" () and loss of the rural countryside to urbanization in "Terrace fields" (). Domestic violence discussed in "Dad, I am back" () received a great deal of commotion since he was the first to bring up this taboo subject in Sanscript music, which helped solidify his status as a pioneer and a unique pop singer capable of approaching serious issues. In the songs "Maternal grandmother" () and "Listen to Mother" (), he voiced his high regard for family values. He addressed personal issues about his failure to enter university in "Split" (), his resentment towards the paparazzi in "Besieged From All Sides" (), and highlighted the importance of individuality in "Popular Imitation" (). "Rice Fragrance" (), a song from his 9th album Capricorn encourages people not to give up their dreams even when facing difficulties in life.
He initiated the band Nan Quan Mama in 2004, selecting band members and overseeing their album production. The group has been noted for sounding too similar to their mentor; as a result, Chou has reduced his involvement in the band, but continues to help increase their exposure to mass audiences by inviting them as guests performers for his own concerts and music videos.
He has performed live duets with Landy Wen, and former girlfriend news anchor Patty Hou, but only two studio recordings of duets have been formally placed in his own albums: "Coral Sea" () in 2005 with Lara Veronin (of Nan Quan Mama) and "Faraway" () in 2006 features Fei Yu-Ching, who began his career in the 1970s. Besides working with singers, Chou's longest-running collaboration is with lyricist Vincent Fang, as they both started their careers in the music field in 1998. The compilation album Partners () featured 12 songs, each consisting of Chou's musical and Fang's lyrical compositions. Fang has written the words to more than 40 of Chou's songs, was the chief editor of Chou's book Grandeur de D Major (), and is now Chou's business partner (together with Chou's manager JR Yang) for the record company JVR Music. Jay Chou was also featured in Cindy Yen's (袁詠琳) song "Sand Painting" (畫沙) released in October 2009. Jay Chou collaborates with Kobe Bryant on "The Heaven and Earth Challenge"(天地一鬥) in order to "promote youth creativity, as well as an upcoming slam-dunk competition in China." The song was released at a press conference before the NBA All-Star Game on February 20, 2011.
Jay held his first series of five solo concerts, titled Fantasy Concert (范特西演唱會), with the first stop on 11 January 2001 at Taoyuan Arena, Taiwan. Followed by two shows at the Hong Kong Coliseum, one in Malaysia and ended in Singapore on 10 February 2002. His second concert tour, The One Concert (The One 演唱會) commenced on 28 September 2002 at Taipei Municipal Stadium, followed by 11 stops and ended at Shenzhen Stadium, China on 3 January 2004.
Two more series of world tours followed: Incomparable Concert (無與倫比演唱會) in 2004 and Jay Chou 2007 World Tours (2007世界巡迴演唱會), with stops in cities such as Taipei, Tokyo, Hong Kong, Beijing, Kuala Lumpur, Singapore, Las Vegas, Toronto and Vancouver. In 2010, to celebrate Jay's 10 year career in the entertainment industry, he embarked on his fifth series of concert tour titled, New Era World Tour (超時代演唱會), with the first stop of three concerts from 11 to 13 June 2010 at Taipei Arena, followed by 24 stops ending in Malaysia on 5 March 2011.
;World tours/Live (DVD) album releases
In February 2007, Chou finally directed his first movie Secret. The story he wrote is based loosely on his relationship with a high school girlfriend, with a plot focused on music, love, and family. He stars as the lead actor of the film with Kwai Lun-Mei as the female lead, and Hong Kong veteran actor Anthony Wong as Chou’s father. Despite previous experience in filming music videos, Chou admits that movies are more challenging due to storyline and time constraints.
In 2005, Jay Chou played the male lead in Initial D, but according to reports, he will be back to direct the sequel, while Andrew Lau, who was a co-director of the first Initial D, will take on the role of the producer.
Despite constant harassment and stalking by the media, he does acknowledge that not all media attention is unwelcome. Coverage by international journals and news agencies such as Time, and Reuters At the end of 2009, he was included on JWT's annual list of 100 Things to Watch in 2010.
In Hong Kong, he has been the best-selling Mandarin artist for the past 4 years. According to a 2004 survey in five Chinese urban centers for children ages 9 to 14, 1 in 6 named Chou as their favorite idol; he was also reported as the favorite singer of youths aged 8 to 25 in a study conducted in seven Asian countries (2006). He has a solid fanbase throughout Southeast Asia, including Singapore, Thailand, Malaysia, Indonesia, and Vietnam.
Currently, Chou remains largely unknown outside of Asia, except in cities with large Chinese immigrant populations such as Los Angeles, New York, San Francisco, Seattle, Vancouver, Toronto, Sydney, Melbourne and Brisbane. He has held concerts in major venues such as the Acer Arena (Sydney - July 3, 2009), HP Pavilion at San Jose (San Jose - December 31, 2010), Los Angeles Memorial Sports Arena (Los Angeles - January 8, 2011), MGM Grand (Las Vegas—December 25, 2002), Rogers Arena (Vancouver - December 23, 2010), Galen Center (Los Angeles—December 24, 2007) and the Air Canada Centre (Toronto - December 18, 2008). His intention to increase his prominence in the Western world beyond Chinese audiences is clear. In 2006, Chou composed and sang the theme song for Fearless, a movie released in major theatres in most English-speaking countries, though the impact to his fame has been minimal. His role in Curse of the Golden Flower (limited release) marks his acting debut in North America. Despite having a supporting but important role in the story's plot, the North American version of the official posters only featured a view of his back, greatly contrasting the Asian versions where his face and name were clear and placed between the leading actor and actress. Although Chou is still far from being well-known to English audiences, this movie has brought him international exposure. Chou gained further exposure to western audiences in his starring role as crimefighter Kato in January 2011's The Green Hornet.
Chou has won the Favorite Male Artist of the 20th Golden Melody Awards in Taiwan. He did not attend the event to collect the award because he was on tour in China at the time.
This text is licensed under the Creative Commons CC-BY-SA License. This text was originally published on Wikipedia and was developed by the Wikipedia community.
Name | Sergei Govorkov |
---|---|
Caption | |
First | His Nickname Is 'Beast' (1989) |
Last | Return of the Furious (2005) |
Nickname | 30th |
Alias | Beast, Rex, Furious |
Title | Sergeant |
Portrayer | Igor Livanov (1992 film)Dmitry Pevtsov (1989 film) |
Creator | Victor Dotsenko |
In the novels his name is Savely – a rare Russian name, which was changed to relatively sounding, more common and catchy. He appeared in more than twenty novels, all of them became a bestsellers.
Complicated tangle, eh? And there is no wonder that KGB, Russian mob and Mujahideen wants him dead or alive. Finally he came back in the USSR, but now it's not the same Country he had left a years ago. New trends, new ideas, new liberties are in the air.
Victor Dotsenko "Terminate the Thirtieth!":
Category:Fictional sergeants Category:Fictional Spetsnaz personnel Category:Fictional war veterans Category:Fictional mercenaries Category:Fictional private military members Category:Characters in Russian novels of the 20th century Category:Russian characters in written fiction
This text is licensed under the Creative Commons CC-BY-SA License. This text was originally published on Wikipedia and was developed by the Wikipedia community.