The F-Series is a series of full-size pickup trucks from Ford Motor Company which has been sold continuously for over six decades. The most popular variant of the F-Series is the F-150. It was the best-selling vehicle in the United States for 24 years, currently the best-selling truck for 34 years, and the best selling vehicle in Canada, though this does not include combined sales of GM pickup trucks. In the tenth generation of the F-series, the F-250 and F-350 changed body style in 1998 and joined the Super Duty series.

During the post-World War II era, smaller Canadian rural communities had access to either a Ford dealer or a Lincoln-Mercury-Meteor dealer, but not both; a Mercury-badged version was sold at Lincoln-Mercury-Meteor dealers there from 1946-1968. Other than the grilles, trim, and badging, these trucks were identical to their Ford counterparts.

The first F-Series truck (known as the Ford Bonus-Built) was introduced in 1948 as a replacement for the previous car-based pickup line introduced in 1941. The F-Series was sold in eight different weight ratings, with pickup, panel truck, cab-over engine (COE), conventional truck, and school bus chassis body styles.

F-100 or F100 may refer to: