Isometheptene (usually as isometheptene mucate) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties, that is, it causes constriction (narrowing) of blood vessels (arteries and veins). Along with paracetamol and dichloralphenazone, it is one of the constituents of Amidrine.
Isometheptene is a monounsaturated aliphatic secondary amine.