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Nialamide (Niamid) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class used as an antidepressant and anxiolytic. Along with phenelzine and isocarboxazid, it is one of the few hydrazine MAOIs still in clinical use.[citation needed]


Nialamide is sometimes used in the treatment of trigeminal neuralgia, generalized anxiety disorder and social phobia. It has also been studied for alcoholism, dermatomally distributed vitiligo, irregular menstruation,angina, cerebrovascular disorders, and the prevention of streptomycin-induced deafness.

Side effects on central nervous system include euphoria, psychomotor agitation, insomnia, anxiety, headache, vertigo, tremor, hyperreflexia, manic state, or turning a depression into mania in bipolar disorder. Other side effects are arterial and orthostatic hypotensions, arterial hypertension, palpitations, hyperhidrosis, dry mouth, nausea, vomiting, epigastric pain, constipation, vision problems, retrobulbar optic neuritis, polyneuritis, weight gain, acute cardiac insufficiency, tachycardia, peripheral neuropathy, jaundice, hepatomegaly, hyperbilirubinemia, urinary retention, elevated transaminases, cutaneous eruptions, impotence, and delayed ejaculation. Dangerous side effects are drug-induced hepatitis and hepatocellular insufficiency.

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This page contains text from Wikipedia, the Free Encyclopedia - http://en.wikipedia.org/wiki/Nialamide

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