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VCAM-1

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VCAM-1

Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. VCAM-1 functions as a cell adhesion molecule.

Structure

The VCAM-1 gene contains six or seven immunoglobulin domains, and is expressed on both large and small blood vessels only after the endothelial cells are stimulated by cytokines. It is alternatively spliced into two known RNA transcripts that encode different isoforms in humans. The gene product is a cell surface sialoglycoprotein, a type I membrane protein that is a member of the Ig superfamily.

Function

The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis.

Upregulation of VCAM-1 in endothelial cells by cytokines occurs as a result of increased gene transcription (e.g., in response to Tumor necrosis factor-alpha (TNF-α) and Interleukin-1 (IL-1)) and through stabilization of Messenger RNA (mRNA) (e.g., Interleukin-4 (IL-4)). The promoter region of the VCAM-1 gene contains functional tandem NF-κB (nuclear factor-kappa B) sites. The sustained expression of VCAM-1 lasts over 24 hours.

This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/VCAM-1

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Latest News for: vcam

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Vape is not tobacco, it is a smoking cessation tool, says VCAM

The Star 24 May 2023

FROM Vape Consumer Association of Malaysia (VCAM) Read full story ... .

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Masimo Announces the Limited Market Release of Visual Clinical Activity Monitoring (VCAM™)

Business Wire 30 Jan 2023

IRVINE, Calif.--(BUSINESS WIRE)--Masimo VCAM™ is a video analysis system that uses AI to help facilitate compliance with hospital hand hygiene protocols ... .

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Church of Jesus Christ of Latter-Day Saints donates $8,000 to VCAM

Victoria Advocate 30 Jun 2022

Representatives of The Church of Jesus Christ of Latter-Day Saints (LDS) presented a donation of $8,000 to the Victoria Christian Assistance Ministries (VCAM .). VCAM is a Christian 501(c)(3) nonprofit organization.

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VCAM-1

Structure

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Latest News for: vcam

Vape is not tobacco, it is a smoking cessation tool, says VCAM

Masimo Announces the Limited Market Release of Visual Clinical Activity Monitoring (VCAM™)

Church of Jesus Christ of Latter-Day Saints donates $8,000 to VCAM

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