- published: 29 Jun 2018
- views: 31343
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Tumor necrosis factor alpha
Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons.
The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease,cancer,major depression,Psoriasis and inflammatory bowel disease (IBD). While still controversial, studies of depression and IBD are currently being linked to TNF levels. Recombinant TNF is used as an immunostimulant under the INN tasonermin. TNF can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Tumor_necrosis_factor_alpha
Podcasts:
-
Tumor necrosis factor (TNF) alpha
By: AMANDA HORNICK
published: 29 Jun 2018 -
Tumor necrosis factor-alpha (TNF-alpha) Mnemonic for USMLE
Tumor necrosis factor-alpha or TNF-alpha for short, is a cytokine secreted by macrophages. TNF alpha signaling causes acute inflammation and fever, both of which help protect the body from infection. Importantly, tnf alpha signaling is also involved in the pathogenesis of Paraneoplastic cachexia. Lastly, tnf alpha signaling is targeted by anti-inflammatory biologic drugs like adalimumab and etanercept, which have the side effect making us more prone to infections like TB. Study this Tumor necrosis factor-alpha or TNF-alpha mnemonic and other USMLE Step 1 / NBME mnemonics with Pixorize. Step 1 / NBME mnemonics with Pixorize. Subscribe for More: https://bit.ly/2yybxhm Study Interactive Image: https://pixorize.com/view/5438 #usmle #step1 #inflammation #infection #mnemonic
published: 30 Jun 2020 -
Learn TNF Alpha in 3 minutes | Tumor necrosis factor alpha, TNFA
This is an introductory video about TNF-α, intended for scientists who need to design controls and perform immunoassays detecting TNF alpha. It contains information about western blot band size, protein expression, and interesting facts. Uniprot: https://www.uniprot.org/uniprot/P01375 Human Protein Atlas: https://www.proteinatlas.org/ENSG00000232810-TNF Western blot images on PMC: https://www.ncbi.nlm.nih.gov/pmc/?term=tnf+alpha+western+blot&report;=imagesdocsum TNF Alpha Antibodies Anti-TNF Alpha Antibody (RP1000): https://www.bosterbio.com/anti-mouse-tnf-alpha-antibody-rp1000-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa Anti-TNF Alpha/Tnf Antibody Picoband™ (A00002-5): https://www.bosterbio.com/anti-tnf-alpha-tnf-picoband-trade-antibody-a00002-5-bost...
published: 12 May 2022 -
Necroptosis | TNF-Alpha Signalling
Necroptosis is a programmed form of necrosis, or inflammatory cell death.Conventionally, necrosis is associated with unprogrammed cell death resulting from cellular damage or infiltration by pathogens, in contrast to orderly, programmed cell death via apoptosis. The discovery of necroptosis showed that cells can execute necrosis in a programmed fashion and that apoptosis is not always the preferred form of cell death. Furthermore, the immunogenic nature of necroptosis favors its participation in certain circumstances, such as aiding in defence against pathogens by the immune system. Necroptosis is well defined as a viral defense mechanism, allowing the cell to undergo "cellular suicide" in a caspase-independent fashion in the presence of viral caspase inhibitors to restrict virus replicati...
published: 07 Oct 2020 -
Increased Effectiveness of Early Therapy With Anti--Tumor Necrosis Factor-α...
Dr. Thomas D. Walters discusses his manuscript "Increased Effectiveness of Early Therapy With Anti--Tumor Necrosis Factor-α vs an Immunomodulator in Children With Crohn's Disease." To view the abstract www.gastrojournal.org/.
published: 15 Jan 2014 -
Role of TNF-alpha Inhibitors in Crohn’s Disease
Marla Dubinsky, MD, identifies the currently approved TNF-alpha inhibitors in Crohn’s disease and her treatment strategy with these agents.
published: 18 Dec 2017 -
Tumor necrosis factor in cancer
For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html Source of all articles published in description is Wikipedia. Thanks to original content developers. Link- http://en.wikipedia.org/wiki/Main_Page Tumor necrosis factors (or the TNF family) refer to a group of cytokines that can cause cell death (apoptosis). The first two members of the family to be identified were: Tumor necrosis factor (TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. TNF is a monocyte-derived cytotoxin that has been implicated in tumor regression, septic shock, and cachexia.[2][3] The protein is synthesized as a prohormone with an unusually long and atypical signal sequence, which i...
published: 03 Dec 2013 -
Vasculitis Associated With Tumor Necrosis Factor-α Inhibitors
Dr. Olayemi Sokumbi, a Resident in the Department of Dermatology at Mayo Clinic in Rochester, MN, discusses her article appearing in the August 2012 issue of Mayo Clinic Proceedings where she describes the clinical characteristics, histopathologic features, and outcomes of patients in whom vasculitis developed in association with use of tumor necrosis factor- inhibitors. Available at: http://www.mayoclinicproceedings.org/article/S0025-6196(12)00560-5/fulltext
published: 15 Oct 2012 -
TNF (Tumor Necrosis factor) - Mechanisms, Disease & Therapy
Also, check out other essential protein targets: Interleukin 4 (IL-4) - Mechanisms, Disease & Therapy https://youtu.be/SOjaTH1pyt0 Interleukin 6 (IL-6) - Mechanisms, Disease & Therapy https://youtu.be/WOT5rXmkDt4 Interleukin 8 (IL-8) - Mechanisms, Disease & Therapy https://youtu.be/G1v6-qBRkq0 Interleukin 10 (IL-10) - Mechanisms, Disease & Therapy https://youtu.be/3bb7SkhEyHo Leptin - Mechanisms, Disease & Therapy https://youtu.be/vy8BWalBTTo TGF - Mechanisms, Disease & Therapy:https://youtu.be/eQMXzkH1J1s TNF (Tumor Necrosis factor) - Mechanisms, Disease & Therapy: https://youtu.be/qcTm4R_AovA VEGF A - Mechanisms, Disease & Therapy https://youtu.be/zmA3Jn0eW3w BDNF - Mechanisms, Disease & Therapy https://youtu.be/EsLEkdpi7jg Interleukin 1 (IL-1) - Mechanisms, Disease & Therapy https://yo...
published: 10 Jan 2018 -
Chronic Inflammation in IBD and How Anti-TNF Therapy Works
This animation describes what anti-TNF-alpha therapies are, how they work, and how patients with inflammatory bowel disease (IBD) can benefit. To learn more visit http://www.YouAndIBD.com
published: 16 Oct 2012
developed with YouTube
8:20
Tumor necrosis factor (TNF) alpha
- Order: Reorder
- Duration: 8:20
- Uploaded Date: 29 Jun 2018
- views: 31343
By: AMANDA HORNICK
By: AMANDA HORNICK
https://wn.com/Tumor_Necrosis_Factor_(Tnf)_Alpha
By: AMANDA HORNICK
6:19
Tumor necrosis factor-alpha (TNF-alpha) Mnemonic for USMLE
- Order: Reorder
- Duration: 6:19
- Uploaded Date: 30 Jun 2020
- views: 34727
Tumor necrosis factor-alpha or TNF-alpha for short, is a cytokine secreted by macrophages. TNF alpha signaling causes acute inflammation and fever, both of whic...
Tumor necrosis factor-alpha or TNF-alpha for short, is a cytokine secreted by macrophages. TNF alpha signaling causes acute inflammation and fever, both of which help protect the body from infection. Importantly, tnf alpha signaling is also involved in the pathogenesis of Paraneoplastic cachexia. Lastly, tnf alpha signaling is targeted by anti-inflammatory biologic drugs like adalimumab and etanercept, which have the side effect making us more prone to infections like TB.
Study this Tumor necrosis factor-alpha or TNF-alpha mnemonic and other USMLE Step 1 / NBME mnemonics with Pixorize.
Step 1 / NBME mnemonics with Pixorize.
Subscribe for More: https://bit.ly/2yybxhm
Study Interactive Image: https://pixorize.com/view/5438
#usmle #step1 #inflammation #infection #mnemonic
https://wn.com/Tumor_Necrosis_Factor_Alpha_(Tnf_Alpha)_Mnemonic_For_Usmle
Tumor necrosis factor-alpha or TNF-alpha for short, is a cytokine secreted by macrophages. TNF alpha signaling causes acute inflammation and fever, both of which help protect the body from infection. Importantly, tnf alpha signaling is also involved in the pathogenesis of Paraneoplastic cachexia. Lastly, tnf alpha signaling is targeted by anti-inflammatory biologic drugs like adalimumab and etanercept, which have the side effect making us more prone to infections like TB.
Study this Tumor necrosis factor-alpha or TNF-alpha mnemonic and other USMLE Step 1 / NBME mnemonics with Pixorize.
Step 1 / NBME mnemonics with Pixorize.
Subscribe for More: https://bit.ly/2yybxhm
Study Interactive Image: https://pixorize.com/view/5438
#usmle #step1 #inflammation #infection #mnemonic
- published: 30 Jun 2020
- views: 34727
3:14
Learn TNF Alpha in 3 minutes | Tumor necrosis factor alpha, TNFA
- Order: Reorder
- Duration: 3:14
- Uploaded Date: 12 May 2022
- views: 4979
This is an introductory video about TNF-α, intended for scientists who need to design controls and perform immunoassays detecting TNF alpha. It contains informa...
This is an introductory video about TNF-α, intended for scientists who need to design controls and perform immunoassays detecting TNF alpha. It contains information about western blot band size, protein expression, and interesting facts.
Uniprot: https://www.uniprot.org/uniprot/P01375
Human Protein Atlas: https://www.proteinatlas.org/ENSG00000232810-TNF
Western blot images on PMC: https://www.ncbi.nlm.nih.gov/pmc/?term=tnf+alpha+western+blot&report;=imagesdocsum
TNF Alpha Antibodies
Anti-TNF Alpha Antibody (RP1000):
https://www.bosterbio.com/anti-mouse-tnf-alpha-antibody-rp1000-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Anti-TNF Alpha/Tnf Antibody Picoband™ (A00002-5): https://www.bosterbio.com/anti-tnf-alpha-tnf-picoband-trade-antibody-a00002-5-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Anti-TNF Alpha Antibody Picoband™ (A00002-3):
https://www.bosterbio.com/anti-tnf-alpha-antibody-a00002-3-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Anti-TNF Alpha Antibody Picoband™ (A00002-2):
https://www.bosterbio.com/anti-tnf-alpha-picoband-trade-antibody-a00002-2-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Anti-TNF Alpha Antibody Picoband™ (PB9010):
https://www.bosterbio.com/anti-tnf-alpha-picoband-trade-antibody-pb9010-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
TNF Alpha ELISA Kits
Human TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0525): https://www.bosterbio.com/human-tnf-alpha-picokine-trade-elisa-kit-ek0525-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0527):
https://www.bosterbio.com/mouse-tnf-alpha-picokine-trade-elisa-kit-ek0527-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Mouse TNF Alpha/Tumor Necrosis Factor PicoKine™ Quick ELISA Kit (FEK0527):
https://www.bosterbio.com/mouse-tnf-alpha-picokine-trade-quick-elisa-kit-fek0527-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Rat TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0526):
https://www.bosterbio.com/rat-tnf-alpha-picokine-trade-elisa-kit-ek0526-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Learn more about TNF Alpha/Tumor necrosis factor (infographic and discussion): https://www.bosterbio.com/bosterbio-gene-info-cards/TNF?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Boster Biological Technology
Website: www.bosterbio.com
Email: support@bosterbio.com
________________________________________________
REFERENCES
Crosswhite, P., Chen, K., & Sun, Z. (2014). AAV Delivery of TNF-α shRNA Attenuates Cold-induced Pulmonary Hypertension and Pulmonary Arterial Remodeling. Hypertension, 64(5), 1141-1150. doi: https://dx.doi.org/10.1161%2FHYPERTENSIONAHA.114.03791
Chen, Y., Pat, B., Zheng, J., Cain, L., Powell, P., Shi, K., … Dell’Italia, L. J. (2010). Tumor necrosis factor-alpha produced in cardiomyocytes mediates a predominant myocardial inflammatory response to stretch in early volume overload. Journal of Molecular and Cellular Cardiology, 49(1,:70-8. doi: https://doi.org/10.1016/j.yjmcc.2009.12.013
Hiyama, A., Yokoyama, K., Nukaga, T., Sakai, D., & Mochida, J. (2013). A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells. Arthritis Research & Therapy, 15(6), R189. doi: https://dx.doi.org/10.1186%2Far4379
https://wn.com/Learn_Tnf_Alpha_In_3_Minutes_|_Tumor_Necrosis_Factor_Alpha,_Tnfa
This is an introductory video about TNF-α, intended for scientists who need to design controls and perform immunoassays detecting TNF alpha. It contains information about western blot band size, protein expression, and interesting facts.
Uniprot: https://www.uniprot.org/uniprot/P01375
Human Protein Atlas: https://www.proteinatlas.org/ENSG00000232810-TNF
Western blot images on PMC: https://www.ncbi.nlm.nih.gov/pmc/?term=tnf+alpha+western+blot&report;=imagesdocsum
TNF Alpha Antibodies
Anti-TNF Alpha Antibody (RP1000):
https://www.bosterbio.com/anti-mouse-tnf-alpha-antibody-rp1000-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Anti-TNF Alpha/Tnf Antibody Picoband™ (A00002-5): https://www.bosterbio.com/anti-tnf-alpha-tnf-picoband-trade-antibody-a00002-5-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Anti-TNF Alpha Antibody Picoband™ (A00002-3):
https://www.bosterbio.com/anti-tnf-alpha-antibody-a00002-3-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Anti-TNF Alpha Antibody Picoband™ (A00002-2):
https://www.bosterbio.com/anti-tnf-alpha-picoband-trade-antibody-a00002-2-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Anti-TNF Alpha Antibody Picoband™ (PB9010):
https://www.bosterbio.com/anti-tnf-alpha-picoband-trade-antibody-pb9010-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
TNF Alpha ELISA Kits
Human TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0525): https://www.bosterbio.com/human-tnf-alpha-picokine-trade-elisa-kit-ek0525-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0527):
https://www.bosterbio.com/mouse-tnf-alpha-picokine-trade-elisa-kit-ek0527-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Mouse TNF Alpha/Tumor Necrosis Factor PicoKine™ Quick ELISA Kit (FEK0527):
https://www.bosterbio.com/mouse-tnf-alpha-picokine-trade-quick-elisa-kit-fek0527-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Rat TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0526):
https://www.bosterbio.com/rat-tnf-alpha-picokine-trade-elisa-kit-ek0526-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Learn more about TNF Alpha/Tumor necrosis factor (infographic and discussion): https://www.bosterbio.com/bosterbio-gene-info-cards/TNF?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Boster Biological Technology
Website: www.bosterbio.com
Email: support@bosterbio.com
________________________________________________
REFERENCES
Crosswhite, P., Chen, K., & Sun, Z. (2014). AAV Delivery of TNF-α shRNA Attenuates Cold-induced Pulmonary Hypertension and Pulmonary Arterial Remodeling. Hypertension, 64(5), 1141-1150. doi: https://dx.doi.org/10.1161%2FHYPERTENSIONAHA.114.03791
Chen, Y., Pat, B., Zheng, J., Cain, L., Powell, P., Shi, K., … Dell’Italia, L. J. (2010). Tumor necrosis factor-alpha produced in cardiomyocytes mediates a predominant myocardial inflammatory response to stretch in early volume overload. Journal of Molecular and Cellular Cardiology, 49(1,:70-8. doi: https://doi.org/10.1016/j.yjmcc.2009.12.013
Hiyama, A., Yokoyama, K., Nukaga, T., Sakai, D., & Mochida, J. (2013). A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells. Arthritis Research & Therapy, 15(6), R189. doi: https://dx.doi.org/10.1186%2Far4379
- published: 12 May 2022
- views: 4979
5:22
Necroptosis | TNF-Alpha Signalling
- Order: Reorder
- Duration: 5:22
- Uploaded Date: 07 Oct 2020
- views: 37016
Necroptosis is a programmed form of necrosis, or inflammatory cell death.Conventionally, necrosis is associated with unprogrammed cell death resulting from cell...
Necroptosis is a programmed form of necrosis, or inflammatory cell death.Conventionally, necrosis is associated with unprogrammed cell death resulting from cellular damage or infiltration by pathogens, in contrast to orderly, programmed cell death via apoptosis. The discovery of necroptosis showed that cells can execute necrosis in a programmed fashion and that apoptosis is not always the preferred form of cell death. Furthermore, the immunogenic nature of necroptosis favors its participation in certain circumstances, such as aiding in defence against pathogens by the immune system. Necroptosis is well defined as a viral defense mechanism, allowing the cell to undergo "cellular suicide" in a caspase-independent fashion in the presence of viral caspase inhibitors to restrict virus replication.[2] In addition to being a response to disease, necroptosis has also been characterized as a component of inflammatory diseases such as Crohn's disease, pancreatitis, and myocardial infarction.[3][4]
The signaling pathway responsible for carrying out necroptosis is generally understood. TNFα leads to stimulation of its receptor TNFR1. TNFR1 binding protein TNFR-associated death protein TRADD and TNF receptor-associated factor 2 TRAF2 signals to RIPK1 which recruits RIPK3 forming the necrosome also named ripoptosome.Phosphorylation of MLKL by the ripoptosome drives oligomerization of MLKL, allowing MLKL to insert into and permeabilize plasma membranes and organelles.Integration of MLKL leads to the inflammatory phenotype and release of damage-associated molecular patterns (DAMPs), which elicit immune responses.
https://wn.com/Necroptosis_|_Tnf_Alpha_Signalling
Necroptosis is a programmed form of necrosis, or inflammatory cell death.Conventionally, necrosis is associated with unprogrammed cell death resulting from cellular damage or infiltration by pathogens, in contrast to orderly, programmed cell death via apoptosis. The discovery of necroptosis showed that cells can execute necrosis in a programmed fashion and that apoptosis is not always the preferred form of cell death. Furthermore, the immunogenic nature of necroptosis favors its participation in certain circumstances, such as aiding in defence against pathogens by the immune system. Necroptosis is well defined as a viral defense mechanism, allowing the cell to undergo "cellular suicide" in a caspase-independent fashion in the presence of viral caspase inhibitors to restrict virus replication.[2] In addition to being a response to disease, necroptosis has also been characterized as a component of inflammatory diseases such as Crohn's disease, pancreatitis, and myocardial infarction.[3][4]
The signaling pathway responsible for carrying out necroptosis is generally understood. TNFα leads to stimulation of its receptor TNFR1. TNFR1 binding protein TNFR-associated death protein TRADD and TNF receptor-associated factor 2 TRAF2 signals to RIPK1 which recruits RIPK3 forming the necrosome also named ripoptosome.Phosphorylation of MLKL by the ripoptosome drives oligomerization of MLKL, allowing MLKL to insert into and permeabilize plasma membranes and organelles.Integration of MLKL leads to the inflammatory phenotype and release of damage-associated molecular patterns (DAMPs), which elicit immune responses.
- published: 07 Oct 2020
- views: 37016
5:08
Increased Effectiveness of Early Therapy With Anti--Tumor Necrosis Factor-α...
- Order: Reorder
- Duration: 5:08
- Uploaded Date: 15 Jan 2014
- views: 922
Dr. Thomas D. Walters discusses his manuscript "Increased Effectiveness of Early Therapy With Anti--Tumor Necrosis Factor-α vs an Immunomodulator in Children Wi...
Dr. Thomas D. Walters discusses his manuscript "Increased Effectiveness of Early Therapy With Anti--Tumor Necrosis Factor-α vs an Immunomodulator in Children With Crohn's Disease." To view the abstract www.gastrojournal.org/.
https://wn.com/Increased_Effectiveness_Of_Early_Therapy_With_Anti_Tumor_Necrosis_Factor_Α...
Dr. Thomas D. Walters discusses his manuscript "Increased Effectiveness of Early Therapy With Anti--Tumor Necrosis Factor-α vs an Immunomodulator in Children With Crohn's Disease." To view the abstract www.gastrojournal.org/.
- published: 15 Jan 2014
- views: 922
7:35
Role of TNF-alpha Inhibitors in Crohn’s Disease
- Order: Reorder
- Duration: 7:35
- Uploaded Date: 18 Dec 2017
- views: 1140
Marla Dubinsky, MD, identifies the currently approved TNF-alpha inhibitors in Crohn’s disease and her treatment strategy with these agents.
Marla Dubinsky, MD, identifies the currently approved TNF-alpha inhibitors in Crohn’s disease and her treatment strategy with these agents.
https://wn.com/Role_Of_Tnf_Alpha_Inhibitors_In_Crohn’S_Disease
Marla Dubinsky, MD, identifies the currently approved TNF-alpha inhibitors in Crohn’s disease and her treatment strategy with these agents.
- published: 18 Dec 2017
- views: 1140
3:00
Tumor necrosis factor in cancer
- Order: Reorder
- Duration: 3:00
- Uploaded Date: 03 Dec 2013
- views: 46638
For more information, log on to-
http://shomusbiology.weebly.com/
Download the study materials here-
http://shomusbiology.weebly.com/bio-materials.html
Source o...
For more information, log on to-
http://shomusbiology.weebly.com/
Download the study materials here-
http://shomusbiology.weebly.com/bio-materials.html
Source of all articles published in description is Wikipedia. Thanks to original content developers.
Link- http://en.wikipedia.org/wiki/Main_Page
Tumor necrosis factors (or the TNF family) refer to a group of cytokines that can cause cell death (apoptosis). The first two members of the family to be identified were:
Tumor necrosis factor (TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. TNF is a monocyte-derived cytotoxin that has been implicated in tumor regression, septic shock, and cachexia.[2][3] The protein is synthesized as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine.[4] A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers.[5] Both the mature protein and a partially processed form of the hormone can be secreted after cleavage of the propeptide.[5]
Lymphotoxin-alpha, formerly known as Tumor necrosis factor-beta (TNF-β), is a cytokine that is inhibited by interleukin 10.[6]
https://wn.com/Tumor_Necrosis_Factor_In_Cancer
For more information, log on to-
http://shomusbiology.weebly.com/
Download the study materials here-
http://shomusbiology.weebly.com/bio-materials.html
Source of all articles published in description is Wikipedia. Thanks to original content developers.
Link- http://en.wikipedia.org/wiki/Main_Page
Tumor necrosis factors (or the TNF family) refer to a group of cytokines that can cause cell death (apoptosis). The first two members of the family to be identified were:
Tumor necrosis factor (TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. TNF is a monocyte-derived cytotoxin that has been implicated in tumor regression, septic shock, and cachexia.[2][3] The protein is synthesized as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine.[4] A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers.[5] Both the mature protein and a partially processed form of the hormone can be secreted after cleavage of the propeptide.[5]
Lymphotoxin-alpha, formerly known as Tumor necrosis factor-beta (TNF-β), is a cytokine that is inhibited by interleukin 10.[6]
- published: 03 Dec 2013
- views: 46638
4:25
Vasculitis Associated With Tumor Necrosis Factor-α Inhibitors
- Order: Reorder
- Duration: 4:25
- Uploaded Date: 15 Oct 2012
- views: 357
Dr. Olayemi Sokumbi, a Resident in the Department of Dermatology at Mayo Clinic in Rochester, MN, discusses her article appearing in the August 2012 issue of Ma...
Dr. Olayemi Sokumbi, a Resident in the Department of Dermatology at Mayo Clinic in Rochester, MN, discusses her article appearing in the August 2012 issue of Mayo Clinic Proceedings where she describes the clinical characteristics, histopathologic features, and outcomes of patients in whom vasculitis developed in association with use of tumor necrosis factor- inhibitors. Available at:
http://www.mayoclinicproceedings.org/article/S0025-6196(12)00560-5/fulltext
https://wn.com/Vasculitis_Associated_With_Tumor_Necrosis_Factor_Α_Inhibitors
Dr. Olayemi Sokumbi, a Resident in the Department of Dermatology at Mayo Clinic in Rochester, MN, discusses her article appearing in the August 2012 issue of Mayo Clinic Proceedings where she describes the clinical characteristics, histopathologic features, and outcomes of patients in whom vasculitis developed in association with use of tumor necrosis factor- inhibitors. Available at:
http://www.mayoclinicproceedings.org/article/S0025-6196(12)00560-5/fulltext
- published: 15 Oct 2012
- views: 357
0:53
TNF (Tumor Necrosis factor) - Mechanisms, Disease & Therapy
- Order: Reorder
- Duration: 0:53
- Uploaded Date: 10 Jan 2018
- views: 692
Also, check out other essential protein targets:
Interleukin 4 (IL-4) - Mechanisms, Disease & Therapy
https://youtu.be/SOjaTH1pyt0
Interleukin 6 (IL-6) - Mecha...
Also, check out other essential protein targets:
Interleukin 4 (IL-4) - Mechanisms, Disease & Therapy
https://youtu.be/SOjaTH1pyt0
Interleukin 6 (IL-6) - Mechanisms, Disease & Therapy https://youtu.be/WOT5rXmkDt4
Interleukin 8 (IL-8) - Mechanisms, Disease & Therapy
https://youtu.be/G1v6-qBRkq0
Interleukin 10 (IL-10) - Mechanisms, Disease & Therapy https://youtu.be/3bb7SkhEyHo
Leptin - Mechanisms, Disease & Therapy https://youtu.be/vy8BWalBTTo
TGF - Mechanisms, Disease & Therapy:https://youtu.be/eQMXzkH1J1s
TNF (Tumor Necrosis factor) - Mechanisms, Disease & Therapy: https://youtu.be/qcTm4R_AovA
VEGF A - Mechanisms, Disease & Therapy
https://youtu.be/zmA3Jn0eW3w
BDNF - Mechanisms, Disease & Therapy
https://youtu.be/EsLEkdpi7jg
Interleukin 1 (IL-1) - Mechanisms, Disease & Therapy
https://youtu.be/n1P5nH2tQbs
Interleukin 2 (IL-2) - Mechanisms, Disease & Therapy
https://youtu.be/N_hM2tGdUxg
https://wn.com/Tnf_(Tumor_Necrosis_Factor)_Mechanisms,_Disease_Therapy
Also, check out other essential protein targets:
Interleukin 4 (IL-4) - Mechanisms, Disease & Therapy
https://youtu.be/SOjaTH1pyt0
Interleukin 6 (IL-6) - Mechanisms, Disease & Therapy https://youtu.be/WOT5rXmkDt4
Interleukin 8 (IL-8) - Mechanisms, Disease & Therapy
https://youtu.be/G1v6-qBRkq0
Interleukin 10 (IL-10) - Mechanisms, Disease & Therapy https://youtu.be/3bb7SkhEyHo
Leptin - Mechanisms, Disease & Therapy https://youtu.be/vy8BWalBTTo
TGF - Mechanisms, Disease & Therapy:https://youtu.be/eQMXzkH1J1s
TNF (Tumor Necrosis factor) - Mechanisms, Disease & Therapy: https://youtu.be/qcTm4R_AovA
VEGF A - Mechanisms, Disease & Therapy
https://youtu.be/zmA3Jn0eW3w
BDNF - Mechanisms, Disease & Therapy
https://youtu.be/EsLEkdpi7jg
Interleukin 1 (IL-1) - Mechanisms, Disease & Therapy
https://youtu.be/n1P5nH2tQbs
Interleukin 2 (IL-2) - Mechanisms, Disease & Therapy
https://youtu.be/N_hM2tGdUxg
- published: 10 Jan 2018
- views: 692
4:41
Chronic Inflammation in IBD and How Anti-TNF Therapy Works
- Order: Reorder
- Duration: 4:41
- Uploaded Date: 16 Oct 2012
- views: 125888
This animation describes what anti-TNF-alpha therapies are, how they work, and how patients with inflammatory bowel disease (IBD) can benefit.
To learn more vis...
This animation describes what anti-TNF-alpha therapies are, how they work, and how patients with inflammatory bowel disease (IBD) can benefit.
To learn more visit http://www.YouAndIBD.com
https://wn.com/Chronic_Inflammation_In_Ibd_And_How_Anti_Tnf_Therapy_Works
This animation describes what anti-TNF-alpha therapies are, how they work, and how patients with inflammatory bowel disease (IBD) can benefit.
To learn more visit http://www.YouAndIBD.com
- published: 16 Oct 2012
- views: 125888
8:20
Tumor necrosis factor (TNF) alpha
By: AMANDA HORNICK
published: 29 Jun 2018
Tumor necrosis factor (TNF) alpha
Tumor necrosis factor (TNF) alpha
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- published: 29 Jun 2018
- views: 31343
By: AMANDA HORNICK
6:19
Tumor necrosis factor-alpha (TNF-alpha) Mnemonic for USMLE
Tumor necrosis factor-alpha or TNF-alpha for short, is a cytokine secreted by macrophages....
published: 30 Jun 2020
Tumor necrosis factor-alpha (TNF-alpha) Mnemonic for USMLE
Tumor necrosis factor-alpha (TNF-alpha) Mnemonic for USMLE
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- published: 30 Jun 2020
- views: 34727
Tumor necrosis factor-alpha or TNF-alpha for short, is a cytokine secreted by macrophages. TNF alpha signaling causes acute inflammation and fever, both of which help protect the body from infection. Importantly, tnf alpha signaling is also involved in the pathogenesis of Paraneoplastic cachexia. Lastly, tnf alpha signaling is targeted by anti-inflammatory biologic drugs like adalimumab and etanercept, which have the side effect making us more prone to infections like TB.
Study this Tumor necrosis factor-alpha or TNF-alpha mnemonic and other USMLE Step 1 / NBME mnemonics with Pixorize.
Step 1 / NBME mnemonics with Pixorize.
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3:14
Learn TNF Alpha in 3 minutes | Tumor necrosis factor alpha, TNFA
This is an introductory video about TNF-α, intended for scientists who need to design cont...
published: 12 May 2022
Learn TNF Alpha in 3 minutes | Tumor necrosis factor alpha, TNFA
Learn TNF Alpha in 3 minutes | Tumor necrosis factor alpha, TNFA
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- published: 12 May 2022
- views: 4979
This is an introductory video about TNF-α, intended for scientists who need to design controls and perform immunoassays detecting TNF alpha. It contains information about western blot band size, protein expression, and interesting facts.
Uniprot: https://www.uniprot.org/uniprot/P01375
Human Protein Atlas: https://www.proteinatlas.org/ENSG00000232810-TNF
Western blot images on PMC: https://www.ncbi.nlm.nih.gov/pmc/?term=tnf+alpha+western+blot&report;=imagesdocsum
TNF Alpha Antibodies
Anti-TNF Alpha Antibody (RP1000):
https://www.bosterbio.com/anti-mouse-tnf-alpha-antibody-rp1000-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Anti-TNF Alpha/Tnf Antibody Picoband™ (A00002-5): https://www.bosterbio.com/anti-tnf-alpha-tnf-picoband-trade-antibody-a00002-5-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Anti-TNF Alpha Antibody Picoband™ (A00002-3):
https://www.bosterbio.com/anti-tnf-alpha-antibody-a00002-3-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Anti-TNF Alpha Antibody Picoband™ (A00002-2):
https://www.bosterbio.com/anti-tnf-alpha-picoband-trade-antibody-a00002-2-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Anti-TNF Alpha Antibody Picoband™ (PB9010):
https://www.bosterbio.com/anti-tnf-alpha-picoband-trade-antibody-pb9010-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
TNF Alpha ELISA Kits
Human TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0525): https://www.bosterbio.com/human-tnf-alpha-picokine-trade-elisa-kit-ek0525-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0527):
https://www.bosterbio.com/mouse-tnf-alpha-picokine-trade-elisa-kit-ek0527-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Mouse TNF Alpha/Tumor Necrosis Factor PicoKine™ Quick ELISA Kit (FEK0527):
https://www.bosterbio.com/mouse-tnf-alpha-picokine-trade-quick-elisa-kit-fek0527-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Rat TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0526):
https://www.bosterbio.com/rat-tnf-alpha-picokine-trade-elisa-kit-ek0526-boster.html?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Learn more about TNF Alpha/Tumor necrosis factor (infographic and discussion): https://www.bosterbio.com/bosterbio-gene-info-cards/TNF?utm_source=youtube&utm;_medium=socialmedia&utm;_campaign=biomarker:tnfa
Boster Biological Technology
Website: www.bosterbio.com
Email: support@bosterbio.com
________________________________________________
REFERENCES
Crosswhite, P., Chen, K., & Sun, Z. (2014). AAV Delivery of TNF-α shRNA Attenuates Cold-induced Pulmonary Hypertension and Pulmonary Arterial Remodeling. Hypertension, 64(5), 1141-1150. doi: https://dx.doi.org/10.1161%2FHYPERTENSIONAHA.114.03791
Chen, Y., Pat, B., Zheng, J., Cain, L., Powell, P., Shi, K., … Dell’Italia, L. J. (2010). Tumor necrosis factor-alpha produced in cardiomyocytes mediates a predominant myocardial inflammatory response to stretch in early volume overload. Journal of Molecular and Cellular Cardiology, 49(1,:70-8. doi: https://doi.org/10.1016/j.yjmcc.2009.12.013
Hiyama, A., Yokoyama, K., Nukaga, T., Sakai, D., & Mochida, J. (2013). A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells. Arthritis Research & Therapy, 15(6), R189. doi: https://dx.doi.org/10.1186%2Far4379
5:22
Necroptosis | TNF-Alpha Signalling
Necroptosis is a programmed form of necrosis, or inflammatory cell death.Conventionally, n...
published: 07 Oct 2020
Necroptosis | TNF-Alpha Signalling
Necroptosis | TNF-Alpha Signalling
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- published: 07 Oct 2020
- views: 37016
Necroptosis is a programmed form of necrosis, or inflammatory cell death.Conventionally, necrosis is associated with unprogrammed cell death resulting from cellular damage or infiltration by pathogens, in contrast to orderly, programmed cell death via apoptosis. The discovery of necroptosis showed that cells can execute necrosis in a programmed fashion and that apoptosis is not always the preferred form of cell death. Furthermore, the immunogenic nature of necroptosis favors its participation in certain circumstances, such as aiding in defence against pathogens by the immune system. Necroptosis is well defined as a viral defense mechanism, allowing the cell to undergo "cellular suicide" in a caspase-independent fashion in the presence of viral caspase inhibitors to restrict virus replication.[2] In addition to being a response to disease, necroptosis has also been characterized as a component of inflammatory diseases such as Crohn's disease, pancreatitis, and myocardial infarction.[3][4]
The signaling pathway responsible for carrying out necroptosis is generally understood. TNFα leads to stimulation of its receptor TNFR1. TNFR1 binding protein TNFR-associated death protein TRADD and TNF receptor-associated factor 2 TRAF2 signals to RIPK1 which recruits RIPK3 forming the necrosome also named ripoptosome.Phosphorylation of MLKL by the ripoptosome drives oligomerization of MLKL, allowing MLKL to insert into and permeabilize plasma membranes and organelles.Integration of MLKL leads to the inflammatory phenotype and release of damage-associated molecular patterns (DAMPs), which elicit immune responses.
5:08
Increased Effectiveness of Early Therapy With Anti--Tumor Necrosis Factor-α...
Dr. Thomas D. Walters discusses his manuscript "Increased Effectiveness of Early Therapy W...
published: 15 Jan 2014
Increased Effectiveness of Early Therapy With Anti--Tumor Necrosis Factor-α...
Increased Effectiveness of Early Therapy With Anti--Tumor Necrosis Factor-α...
- Report rights infringement
- published: 15 Jan 2014
- views: 922
Dr. Thomas D. Walters discusses his manuscript "Increased Effectiveness of Early Therapy With Anti--Tumor Necrosis Factor-α vs an Immunomodulator in Children With Crohn's Disease." To view the abstract www.gastrojournal.org/.
7:35
Role of TNF-alpha Inhibitors in Crohn’s Disease
Marla Dubinsky, MD, identifies the currently approved TNF-alpha inhibitors in Crohn’s dise...
published: 18 Dec 2017
Role of TNF-alpha Inhibitors in Crohn’s Disease
Role of TNF-alpha Inhibitors in Crohn’s Disease
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- published: 18 Dec 2017
- views: 1140
Marla Dubinsky, MD, identifies the currently approved TNF-alpha inhibitors in Crohn’s disease and her treatment strategy with these agents.
3:00
Tumor necrosis factor in cancer
For more information, log on to-
http://shomusbiology.weebly.com/
Download the study mater...
published: 03 Dec 2013
Tumor necrosis factor in cancer
Tumor necrosis factor in cancer
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- published: 03 Dec 2013
- views: 46638
For more information, log on to-
http://shomusbiology.weebly.com/
Download the study materials here-
http://shomusbiology.weebly.com/bio-materials.html
Source of all articles published in description is Wikipedia. Thanks to original content developers.
Link- http://en.wikipedia.org/wiki/Main_Page
Tumor necrosis factors (or the TNF family) refer to a group of cytokines that can cause cell death (apoptosis). The first two members of the family to be identified were:
Tumor necrosis factor (TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. TNF is a monocyte-derived cytotoxin that has been implicated in tumor regression, septic shock, and cachexia.[2][3] The protein is synthesized as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine.[4] A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers.[5] Both the mature protein and a partially processed form of the hormone can be secreted after cleavage of the propeptide.[5]
Lymphotoxin-alpha, formerly known as Tumor necrosis factor-beta (TNF-β), is a cytokine that is inhibited by interleukin 10.[6]
4:25
Vasculitis Associated With Tumor Necrosis Factor-α Inhibitors
Dr. Olayemi Sokumbi, a Resident in the Department of Dermatology at Mayo Clinic in Rochest...
published: 15 Oct 2012
Vasculitis Associated With Tumor Necrosis Factor-α Inhibitors
Vasculitis Associated With Tumor Necrosis Factor-α Inhibitors
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- published: 15 Oct 2012
- views: 357
Dr. Olayemi Sokumbi, a Resident in the Department of Dermatology at Mayo Clinic in Rochester, MN, discusses her article appearing in the August 2012 issue of Mayo Clinic Proceedings where she describes the clinical characteristics, histopathologic features, and outcomes of patients in whom vasculitis developed in association with use of tumor necrosis factor- inhibitors. Available at:
http://www.mayoclinicproceedings.org/article/S0025-6196(12)00560-5/fulltext
0:53
TNF (Tumor Necrosis factor) - Mechanisms, Disease & Therapy
Also, check out other essential protein targets:
Interleukin 4 (IL-4) - Mechanisms, Disea...
published: 10 Jan 2018
TNF (Tumor Necrosis factor) - Mechanisms, Disease & Therapy
TNF (Tumor Necrosis factor) - Mechanisms, Disease & Therapy
- Report rights infringement
- published: 10 Jan 2018
- views: 692
Also, check out other essential protein targets:
Interleukin 4 (IL-4) - Mechanisms, Disease & Therapy
https://youtu.be/SOjaTH1pyt0
Interleukin 6 (IL-6) - Mechanisms, Disease & Therapy https://youtu.be/WOT5rXmkDt4
Interleukin 8 (IL-8) - Mechanisms, Disease & Therapy
https://youtu.be/G1v6-qBRkq0
Interleukin 10 (IL-10) - Mechanisms, Disease & Therapy https://youtu.be/3bb7SkhEyHo
Leptin - Mechanisms, Disease & Therapy https://youtu.be/vy8BWalBTTo
TGF - Mechanisms, Disease & Therapy:https://youtu.be/eQMXzkH1J1s
TNF (Tumor Necrosis factor) - Mechanisms, Disease & Therapy: https://youtu.be/qcTm4R_AovA
VEGF A - Mechanisms, Disease & Therapy
https://youtu.be/zmA3Jn0eW3w
BDNF - Mechanisms, Disease & Therapy
https://youtu.be/EsLEkdpi7jg
Interleukin 1 (IL-1) - Mechanisms, Disease & Therapy
https://youtu.be/n1P5nH2tQbs
Interleukin 2 (IL-2) - Mechanisms, Disease & Therapy
https://youtu.be/N_hM2tGdUxg
4:41
Chronic Inflammation in IBD and How Anti-TNF Therapy Works
This animation describes what anti-TNF-alpha therapies are, how they work, and how patient...
published: 16 Oct 2012
Chronic Inflammation in IBD and How Anti-TNF Therapy Works
Chronic Inflammation in IBD and How Anti-TNF Therapy Works
- Report rights infringement
- published: 16 Oct 2012
- views: 125888
This animation describes what anti-TNF-alpha therapies are, how they work, and how patients with inflammatory bowel disease (IBD) can benefit.
To learn more visit http://www.YouAndIBD.com
Tumor necrosis factor alpha
Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons.
The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease,cancer,major depression,Psoriasis and inflammatory bowel disease (IBD). While still controversial, studies of depression and IBD are currently being linked to TNF levels. Recombinant TNF is used as an immunostimulant under the INN tasonermin. TNF can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Tumor_necrosis_factor_alpha
Tumor necrosis factor (TNF) alpha...
Tumor necrosis factor-alpha (TNF-alpha) Mnemonic f...
Learn TNF Alpha in 3 minutes | Tumor necrosis fact...
Necroptosis | TNF-Alpha Signalling...
Increased Effectiveness of Early Therapy With Anti...
Role of TNF-alpha Inhibitors in Crohn’s Disease...
Tumor necrosis factor in cancer...
Vasculitis Associated With Tumor Necrosis Factor-α...
TNF (Tumor Necrosis factor) - Mechanisms, Disease ...
Chronic Inflammation in IBD and How Anti-TNF Thera...
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