In recent decades, domperidone has gained popularity in the breastfeeding community and has been used off-label to treat low milk supply. Domperidone’s major drawbacks are rare, but severe, including heart complications (cardiac arrhythmias due to QT-prolongation), weight gain, and anxiety or depression when it is discontinued. Average increases in daily milk volume are around 1.7 ounces (60 mL), which can be significant for premature infants, but less so for babies as they grow older. Currently domperidone is banned in the United States (US) and its consumption may complicate receiving healthcare in the US.