Depression can affect people in many different ways. Many people with depression experience a persistent loss of pleasure. They may also lose interest in hobbies and usual activities. Feelings of guilt, worthlessness, sadness, and anxiety may also occur. Depression can cause fatigue, pain, and headache. Some people experience difficulty sleeping. Others may spend excessive amounts of time sleeping. Depression can also affect body weight. Some people experience weight gain. Others may lose their appetite and notice weight loss.