Take this medication by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Do not crush, chew, or cut these tablets. This medication is taken once daily at the same time each day. Do not take your medication more often than directed. Do not stop taking this medication suddenly except upon the advice of your care team. Stopping this medication too quickly may cause serious side effects or your condition may worsen. A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time. Talk to your care team about the use of this medication in children. Special care may be needed.

Side effects that you should report to your care team as soon as possible:

• Allergic reactions--skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Increase in blood pressure
• Mood and behavior changes--anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
• Redness, blistering, peeling, or loosening of the skin, including inside the mouth
• Seizures
• Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
• Constipation
• Dizziness
• Dry mouth
• Loss of appetite
• Nausea
• Tremors or shaking
• Trouble sleeping

Our pharmacists will check to see if this medication will cause any interactions with the information in your profile.

Do not take this medication with any of the following:

• Linezolid
• MAOIs like Azilect, Carbex, Eldepryl, Marplan, Nardil, and Parnate
• Methylene blue (injected into a vein)
• Other medications that contain bupropion like Zyban This medication may also interact with the following:
• Alcohol
• Certain medications for anxiety or sleep
• Certain medications for blood pressure like metoprolol, propranolol
• Certain medications for depression or psychotic disturbances
• Certain medications for HIV or AIDS like efavirenz, lopinavir, nelfinavir, ritonavir
• Certain medications for irregular heart beat like propafenone, flecainide
• Certain medications for Parkinson's disease like amantadine, levodopa
• Certain medications for seizures like carbamazepine, phenytoin, phenobarbital
• Cimetidine
• Clopidogrel
• Cyclophosphamide
• Digoxin
• Furazolidone
• Isoniazid
• Nicotine
• Orphenadrine
• Procarbazine
• Steroid medications like prednisone or cortisone
• Stimulant medications for attention disorders, weight loss, or to stay awake
• Tamoxifen
• Theophylline
• Thiotepa
• Ticlopidine
• Tramadol
• Warfarin