Overview

Explaining epilepsy

Listen to specialist Lily Wong-Kisiel, M.D., walk through the epilepsy basics.

Hi, I'm Dr. Lily Wong-Kisiel, a pediatric neurologist at Mayo Clinic. In this video, we'll cover the basics of epilepsy. What is it? Who gets it? The symptoms diagnosis and treatment. Whether you're looking for answers for yourself or someone you love, we're here to give you the best information available. First of all, epilepsy is common. Around 3 million people in the U.S. have epilepsy, making it the fourth most common neurological disease after migraine, stroke and Alzheimer's. Epilepsy happens as a result of abnormal electrical brain activity, also known as a seizure, kind of like an electrical storm inside your head. And because your brain controls so much, a lot of different things can go wrong. You may have periods of unusual behaviors, feelings and sometimes loss of awareness. There are many types of seizures, including two main categories: focal, meaning they start in a particular part of your brain, or generalized, meaning the seizures initially involve all areas of the brain. There are some myths about epilepsy we can dismiss. If you are with someone experiencing a seizure, don't put anything in their mouth. They can't actually swallow their tongue. Don't restrain them. And don't worry, epilepsy isn't contagious, so you can't catch it.

Although children or older adults are more susceptible, anyone can develop epilepsy. When epilepsy is diagnosed in older adults, it's sometimes from another neurological issue, like a stroke or a brain tumor. Other causes can be related to genetic abnormalities, prior brain infection, prenatal injuries or developmental disorders. But in about half of people with epilepsy, there's no apparent cause.

Because they happen in the brain, seizures can affect any process your brain handles. Therefore, symptoms can vary. Many individuals with epilepsy tend to have the same type of seizure each time. However, some will have more than one type. So, how do you recognize a seizure? Keep an eye out for temporary confusion, a staring spell, uncontrollable jerking, loss of consciousness, fear, anxiety or deja vu.

Let's talk about the two types of seizures again: focal and generalized. Focal seizures happen one of two ways: without loss of awareness or with impaired awareness. In those where you remain conscious, you may experience altered emotions or change in sensation like smell, sound or taste. You may also have dizziness, tingling or see flashing lights. You could also experience involuntary jerking of body parts like your arm or your leg. When you lose or have altered awareness, you can pass out or stare into space and not really respond normally. Hand rubbing, chewing, swallowing or walking in circles can happen in this kind of seizure. Because these symptoms overlap with migraine or other neurological disorders, heart problems or psychiatric conditions, tests are needed for a diagnosis. Generalized onset seizures, the ones that happen across all areas of the brain, show up in a variety of ways. Absence seizures are marked by staring absently into space. Blinking and lip smacking can also happen. Tonic seizures involve a stiffening of the back, arm and legs. The opposite of tonic seizures are atonic seizures, which result in a loss of muscle control. Instead of going stiff, everything goes slack. Clonic seizures usually affect the neck, face and arms with repeated jerking movements. Similar to clonic seizure, myoclonic seizures involve sudden brief jerks or twitches of the arms. Lastly, there are tonic-clonic seizures. Like the name suggests, these involve parts of both tonic and clonic signs. Body stiffening and shaking, loss of bladder control or biting your tongue can also happen. Knowing the kind of seizure you have is key to treatment.

Even after having a single seizure, sometimes the diagnosis of epilepsy can't be made. Regardless, if you do have something that seems like a first-time seizure, see a physician. Your doctor may assess your motor abilities, mental function and other areas to diagnose your condition and determine if you have epilepsy. They may also order additional diagnostic tests. They could include neurological exam, blood tests, EEG, CT scan, brain imaging and sometimes neuropsychological tests. Because your brain is such a complicated piece of machinery, neurologists, epileptologists, neurosurgeons, neuroradiologists, mental health specialists, and other professionals all work together to provide exactly the care you need.

The best care starts with an accurate diagnosis. The medications we have for epilepsy are incredibly effective. More than half of the cases are seizure-free after their first medication. But when medication does not work at stopping seizures completely, there are other emerging ways of treating epilepsy, including surgery and brain stimulation. And a comprehensive level 4 epilepsy center can help find you the best way to manage your care. For patients undergoing treatment, it's important to keep a detailed seizure journal. Each time you have a seizure, write down the time, the type and how long it lasted, making note of anything out of the ordinary, like missed medication, sleep deprivation, increased stress, menstruation, or anything else that could trigger it.

Though we don't always know why people suffer from epilepsy, ongoing research continues to build our knowledge and improve treatment options. And better treatment means happier patients. If you'd like to learn even more about epilepsy, watch our other related videos or visit mayoclinic.org. We wish you well.

Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness.

Anyone can develop epilepsy. Epilepsy affects both males and females of all races, ethnic backgrounds and ages.

Seizure symptoms can vary widely. Some people with epilepsy simply stare blankly for a few seconds during a seizure, while others repeatedly twitch their arms or legs. Having a single seizure doesn't mean you have epilepsy. At least two seizures without a known trigger (unprovoked seizures) that happen at least 24 hours apart are generally required for an epilepsy diagnosis.

Treatment with medications or sometimes surgery can control seizures for the majority of people with epilepsy. Some people require lifelong treatment to control seizures, but for others, the seizures eventually go away. Some children with epilepsy may outgrow the condition with age.

Symptoms

Because epilepsy is caused by abnormal activity in the brain, seizures can affect any process your brain coordinates. Seizure signs and symptoms may include:

  • Temporary confusion
  • A staring spell
  • Stiff muscles
  • Uncontrollable jerking movements of the arms and legs
  • Loss of consciousness or awareness
  • Psychological symptoms such as fear, anxiety or deja vu

Symptoms vary depending on the type of seizure. In most cases, a person with epilepsy will tend to have the same type of seizure each time, so the symptoms will be similar from episode to episode.

Doctors generally classify seizures as either focal or generalized, based on how and where the abnormal brain activity begins.

Focal seizures

When seizures appear to result from abnormal activity in just one area of your brain, they're called focal seizures. These seizures fall into two categories:

  • Focal seizures without loss of consciousness. Once called simple partial seizures, these seizures don't cause a loss of consciousness. They may alter emotions or change the way things look, smell, feel, taste or sound. Some people experience deja vu. This type of seizure may also result in involuntary jerking of one body part, such as an arm or leg, and spontaneous sensory symptoms such as tingling, dizziness and flashing lights.
  • Focal seizures with impaired awareness. Once called complex partial seizures, these seizures involve a change or loss of consciousness or awareness. This type of seizure may seem like being in a dream. During a focal seizure with impaired awareness, you may stare into space and not respond normally to your environment or perform repetitive movements, such as hand rubbing, chewing, swallowing or walking in circles.

Symptoms of focal seizures may be confused with other neurological disorders, such as migraine, narcolepsy or mental illness. A thorough examination and testing are needed to distinguish epilepsy from other disorders.

Generalized seizures

Seizures that appear to involve all areas of the brain are called generalized seizures. Six types of generalized seizures exist.

  • Absence seizures. Absence seizures, previously known as petit mal seizures, typically occur in children. They're characterized by staring into space with or without subtle body movements such as eye blinking or lip smacking and only last between 5-10 seconds. These seizures may occur in clusters, happening as often as 100 times per day, and cause a brief loss of awareness.
  • Tonic seizures. Tonic seizures cause stiff muscles and may affect consciousness. These seizures usually affect muscles in your back, arms and legs and may cause you to fall to the ground.
  • Atonic seizures. Atonic seizures, also known as drop seizures, cause a loss of muscle control. Since this most often affects the legs, it often causes you to suddenly collapse or fall down.
  • Clonic seizures. Clonic seizures are associated with repeated or rhythmic, jerking muscle movements. These seizures usually affect the neck, face and arms.
  • Myoclonic seizures. Myoclonic seizures usually appear as sudden brief jerks or twitches and usually affect the upper body, arms and legs.
  • Tonic-clonic seizures. Tonic-clonic seizures, previously known as grand mal seizures, are the most dramatic type of epileptic seizure. They can cause an abrupt loss of consciousness and body stiffening, twitching and shaking. They sometimes cause loss of bladder control or biting your tongue.

When to see a doctor

Seek immediate medical help if any of the following occurs:

  • The seizure lasts more than five minutes.
  • Breathing or consciousness doesn't return after the seizure stops.
  • A second seizure follows immediately.
  • You have a high fever.
  • You're pregnant.
  • You have diabetes.
  • You've injured yourself during the seizure.
  • You continue to have seizures even though you've been taking anti-seizure medication.

If you experience a seizure for the first time, seek medical advice.

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Causes

Epilepsy has no identifiable cause in about half the people with the condition. In the other half, the condition may be traced to various factors, including:

  • Genetic influence. Some types of epilepsy, which are categorized by the type of seizure you experience or the part of the brain that is affected, run in families. In these cases, it's likely that there's a genetic influence.

    Researchers have linked some types of epilepsy to specific genes, but for most people, genes are only part of the cause of epilepsy. Certain genes may make a person more sensitive to environmental conditions that trigger seizures.

  • Head trauma. Head trauma as a result of a car accident or other traumatic injury can cause epilepsy.
  • Brain abnormalities. Abnormalities in the brain, including brain tumors or vascular malformations such as arteriovenous malformations (AVMs) and cavernous malformations, can cause epilepsy. Stroke is a leading cause of epilepsy in adults older than age 35.
  • Infections. Meningitis, HIV, viral encephalitis and some parasitic infections can cause epilepsy.
  • Prenatal injury. Before birth, babies are sensitive to brain damage that could be caused by several factors, such as an infection in the mother, poor nutrition or oxygen deficiencies. This brain damage can result in epilepsy or cerebral palsy.
  • Developmental disorders. Epilepsy can sometimes be associated with developmental disorders, such as autism.

Risk factors

Certain factors may increase your risk of epilepsy:

  • Age. The onset of epilepsy is most common in children and older adults, but the condition can occur at any age.
  • Family history. If you have a family history of epilepsy, you may be at an increased risk of developing a seizure disorder.
  • Head injuries. Head injuries are responsible for some cases of epilepsy. You can reduce your risk by wearing a seat belt while riding in a car and by wearing a helmet while bicycling, skiing, riding a motorcycle or engaging in other activities with a high risk of head injury.
  • Stroke and other vascular diseases. Stroke and other blood vessel (vascular) diseases can lead to brain damage that may trigger epilepsy. You can take a number of steps to reduce your risk of these diseases, including limiting your intake of alcohol and avoiding cigarettes, eating a healthy diet, and exercising regularly.
  • Dementia. Dementia can increase the risk of epilepsy in older adults.
  • Brain infections. Infections such as meningitis, which causes inflammation in your brain or spinal cord, can increase your risk.
  • Seizures in childhood. High fevers in childhood can sometimes be associated with seizures. Children who have seizures due to high fevers generally won't develop epilepsy. The risk of epilepsy increases if a child has a long fever-associated seizure, another nervous system condition or a family history of epilepsy.

Complications

Having a seizure at certain times can lead to circumstances that are dangerous to yourself or others.

  • Falling. If you fall during a seizure, you can injure your head or break a bone.
  • Drowning. If you have epilepsy, you're 13-19 times more likely to drown while swimming or bathing than the rest of the population because of the possibility of having a seizure while in the water.
  • Car accidents. A seizure that causes either loss of awareness or control can be dangerous if you're driving a car or operating other equipment.

    Many states have driver's license restrictions related to a driver's ability to control seizures and impose a minimum amount of time that a driver be seizure-free, ranging from months to years, before being allowed to drive.

  • Pregnancy complications. Seizures during pregnancy pose dangers to both mother and baby, and certain anti-epileptic medications increase the risk of birth defects. If you have epilepsy and you're considering becoming pregnant, talk to your doctor as you plan your pregnancy.

    Most women with epilepsy can become pregnant and have healthy babies. You'll need to be carefully monitored throughout pregnancy, and medications may need to be adjusted. It's very important that you work with your doctor to plan your pregnancy.

  • Emotional health issues. People with epilepsy are more likely to have psychological problems, especially depression, anxiety, and suicidal thoughts and behaviors. Problems may be a result of difficulties dealing with the condition itself as well as medication side effects, but even people with well-controlled epilepsy are at increased risk.

Other life-threatening complications of epilepsy are uncommon, but may happen, such as:

  • Status epilepticus. This condition occurs if you're in a state of continuous seizure activity lasting more than five minutes or if you have frequent recurrent seizures without regaining full consciousness in between them. People with status epilepticus have an increased risk of permanent brain damage and death.
  • Sudden unexpected death in epilepsy (SUDEP). People with epilepsy also have a small risk of sudden unexpected death. The cause is unknown, but some research shows it may occur due to heart or respiratory conditions.

    People with frequent tonic-clonic seizures or people whose seizures aren't controlled by medications may be at higher risk of SUDEP. Overall, about 1% of people with epilepsy die of SUDEP. It's most common in those with severe epilepsy that doesn't respond to treatment.

Epilepsy care at Mayo Clinic

Oct. 07, 2021
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