POLE4

POLE4
Identifiers
Aliases	POLE4, YHHQ1, p12, polymerase (DNA) epsilon 4, accessory subunit, DNA polymerase epsilon 4, accessory subunit
External IDs	OMIM: 607269 MGI: 1914229 HomoloGene: 41339 GeneCards: POLE4
Gene location (Human) Chr. Chromosome 2 (human) Band 2p12 Start 74,958,643 bp End 74,970,128 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 C3 Start 82,595,973 bp End 82,682,346 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cingulate gyrus popliteal artery monocyte Left adrenal gland gastrocnemius muscle left coronary artery prefrontal cortex amygdala thoracic aorta ascending aorta Top expressed in secondary oocyte yolk sac retinal pigment epithelium ciliary body iris proximal tubule ureter endocardial cushion barrel cortex neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity DNA binding DNA-directed DNA polymerase activity nucleotidyltransferase activity protein binding protein heterodimerization activity Cellular component epsilon DNA polymerase complex nucleus nucleoplasm Biological process histone H3 acetylation DNA biosynthetic process G1/S transition of mitotic cell cycle DNA replication initiation telomere maintenance via semi-conservative replication Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56655 66979 Ensembl ENSG00000115350 ENSMUSG00000030042 UniProt Q9NR33 Q9CQ36 RefSeq (mRNA) NM_019896 NM_025882 NM_001370295 RefSeq (protein) NP_063949 NP_080158 NP_001357224 Location (UCSC) Chr 2: 74.96 – 74.97 Mb Chr 6: 82.6 – 82.68 Mb PubMed search
Wikidata
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Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.

Function

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.

Further reading

• Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
• Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J. Biol. Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.
• Wang YL, Faiola F, Xu M, Pan S, Martinez E (2008). "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein". J. Biol. Chem. 283 (49): 33808–15. doi:10.1074/jbc.M806936200. PMC 2590711. PMID 18838386.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.