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- Sanitation Facilities Construction, Division of
- Scholarships Program
- Self-Governance (OTSG), Office of Tribal
- Sexual Abuse Prevention
- Sexual Assault, Health Topic
- Social Media
- Special Diabetes Program for Indians (SDPI)
- Standard Code Book (SCB)
- Strategic Plan
- Statistics, Division of Program
- Substance Abuse Program, Alcohol and
- Substance Abuse and Suicide Prevention (SASP) program (formerly MSPI)
- Suicide Prevention Program