The GiveWell Blog

IPTi for malaria: a promising intervention with likely room to scale

Intermittent preventive treatment in infants (IPTi) for malaria provides preventive antimalarial medicine to children under 12 months old. It is among the most promising programs we’ve identified in our active pipeline of new interventions. It’s also underutilized, and the population it targets is especially vulnerable to malaria. That implies potential to open up large amounts of room for more funding if IPTi begins to be used more widely—our crude estimate is between $50 million and $200 million globally once it’s scaled—which is something we’re increasingly thinking about as we aim to direct $1 billion in cost-effective funding by 2025. In September 2021, we recommended a small grant to Malaria Consortium and PATH to assess the feasibility and cost-effectiveness of implementing IPTi at national scale in two countries. We’re hopeful that this scoping exercise will answer some of our many open questions about IPTi, and that this intervention continues to look promising as we learn more.

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Our recommendations for giving in 2021

You can have a remarkable impact by supporting cost-effective, evidence-based charities.

Just looking at the approximately $100 million GiveWell had discretion to grant in 2020—a subset of all the money we directed to the charities we recommend—the impact of our donors is impressive. We estimate these grants will:

  • Save more than 24,000 lives
  • Treat over 6 million children with a full course of antimalarial medication
  • Provide vitamin A supplementation to over 8.6 million children
  • Deliver over 4.4 million long-lasting insecticide-treated nets (LLINs) to protect against malaria
  • Vaccinate 118,000 children
  • Treat over 11.4 million children for parasitic worms

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We aim to cost-effectively direct around $1 billion annually by 2025

A little over a decade ago in 2010, GiveWell directed around $1.5 million to the charities we recommended. In 2021, we expect we’ll raise at least $500 million, and may raise as much as $560 million or more.

We never anticipated that we’d grow this large this quickly. We’ve seen rapid growth from donors of all sizes, the most recent of which is a commitment of $300 million from Open Philanthropy.

While this growth comes with challenges—we’re working hard to hire enough researchers—it’s a testament to our donors’ trust in us and enthusiasm for our mission.

But these big numbers are relatively small in the long-term scope of what GiveWell hopes to achieve. We believe there are billions of dollars’ worth of annual cost-effective giving opportunities that we have yet to identify.

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