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- U & I Nonprofit Corporation
- U CAN-CER VIVE Foundation
- U FIRST
- U S Green Building Council Inc
- U S Green Building Council- Minnesota Chapter Inc
- U S Kennels Incorporated
- U S Space Walk of Fame Foundation
- U Turn For Christ Greeneville
- U-TOUCH
- U.S. Capitol Historical Society
- U.S. Veterans Rowing & Kayaking Foundation
- U.S.VETS
- UC Berkeley SAGE Scholars Program
- UCAN
- UCOM UrbanServ Inc
- UCP Central PA
- Udavum Karangal Of Usa
- Udayan Care
- Udyama
- Uganda for her Initiative
- Ugandan Lambs Association USA
- Uja Federation of Greenwich
- UKANDU
- Ukraine Orphan Outreach
- Ulman Cancer Fund For Young Adults
- Ulster County SPCA
- Ultimate Veteran Adventures Foundation Inc
- Umbrella of the Capital District, Inc.
- Umma-Urban Muslim Minority Alliance
- Umoja Student Development Corporation
- UMOM New Day Centers Inc
- Umps Care Charities Inc
- Umuco Love
- Unbound
- Unbridled Hope Inc
- Unbridled Joy Inc
- Unbridled Thoroughbred Foundation
- Uncaged Paws Inc
- Uncle Asia
- Under My Wing Avian Refuge AKA Under My Wing AKA UMWAR
- Under One Roof, Inc.
- Underdog Association
- Undies for Everyone
- Unheard Voices U S A
- UNICEF USA
- Unidos Por La Musica
- Unified Progress International (UPI) Education Inc.
- Uniformed Services Justice & Advocacy Group (USJAG)
- Uniformed Services Peer Council
- Unifour One
- Union County Historical Society
- Union Gospel Mission of Tarrant County
- Union Gospel Mission Sacramento
- Union of Concerned Scientists, Inc.
- Union Project
- Union Rescue Mission
- Union Station Homeless Services
- Unitarian Fellowship for World Peace
- Unite & Inspire
- Unite For Her
- Unite Oregon
- Unite to Light
- United Against Slavery, LLC
- UNITED AMERICAN PATRIOTS INC
- United Animal Coalition Inc
- United Animal Friends Inc
- United Arts Council of Greensboro Inc
- UNITED BRACHIAL PLEXUS NETWORK
- United By Friendship Inc
- United Cancer Support Foundation
- United Caring Shelters Inc
- United Cerebral Palsy (UCP) of Central Florida, Inc.
- United Cerebral Palsy of Greater Dane County, Inc.
- United Cerebral Palsy of South Carolina Inc
- United Charitable
- United Christian Faith Ministries
- United Christian Ministries Of Jackson County Inc
- UNITED COMMUNITIES AGAINST POVERTY INC
- United Community
- United Food Bank
- United for a Fair Economy
- United for the People
- United Foundation Of Central Florida, Inc.
- United Fund of Cumberland County
- United Global Outreach Inc
- United Hands Relief
- United Horsemens Front
- United in Light, Inc.
- United International Buddha Dhamma Inc
- United Methodist Childrens Home
- United Methodist Childrens Home Of North Georgia Conference Inc
- United Methodist Church & Its Affiliated Organizations
- United Methodist Family Services of Virginia (UMFS)
- United Methodist Neighborhood Centers, Inc.
- UNITED MIDCOAST CHARITIES INC
- United Military Care, Inc.
- United Mission for Relief & Development (UMR)
- United Mitochondrial Disease Foundation Inc
- UNITED MOVEMENT ORGANIZED KINDNESS
- United Negro College Fund Inc