This International Day of Women & Girls in Science (11 Feb), we caught up with Dr Sarah Mizielinska (UK DRI at King’s) to find out more about her cutting-edge research into the mislocalisation of proteins, the importance of a multidisciplinary approach and her experiences starting a new family and lab group in academia.
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We know that often in neurodegenerative conditions, changes to the brain begin decades before symptoms appear. Many believe therefore that we stand a better chance of slowing or stopping the disease process, if we intervene with treatments at the earliest stages. A new cutting-edge platform from UK DRI is set to transform how we identify those who are at most risk of developing diseases associated with dementia.
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The Global Burden of Disease study examines the impact of major dementia risk factors on projections, and urges significant intervention through lifestyle changes, expanded health and social care resources and investment in research to find much-needed treatments. UK DRI Director Prof Bart De Strooper comments on the findings.
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Co-founded by Prof Chris Shaw (UK DRI at King's), AviadoBio will use a patented gene therapy platform to develop innovative treatments for people living with neurodegenerative diseases. If successful, these treatments have the potential to permanently correct faulty genes, transforming the lives of individuals affected.
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The Dementia UK Ecosystem (DUKE) brings together leaders from the UK DRI, Dementias Platform UK, the National Institute for Health Research, the pharmaceutical industry, and funders to create a cohesive community, coordinating efforts to accelerate progress in tackling dementia.
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Group Leader Dr Nir Grossman (UK DRI at Imperial) is leading a new trial using deep electrical currents applied to the brain of people living with Alzheimer's disease. The team are recruiting participants over the next year.
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We have a clearly defined vision at the UK DRI to develop effective therapeutics, diagnostics and technologies for people living with dementia. Alongside building our disease knowledge over the coming years, we will also make progress in translating these discoveries into the clinic.
Translation and innovation
We accelerate, innovate, deepen and broaden discovery science in dementia, with the goal of filling the huge knowledge gap in this field. We exist to bring forward the day when research benefits people living with and those at risk of dementia.
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Our efforts to increase the diversity of our team, ensure inclusion and promote equality of opportunity, align with our vision for the UK DRI’s Institute culture and identity as a world-leader in dementia research.
Equity, Diversity and Inclusion
We study a range of neurodegenerative disorders that cause dementia. Many of them share fundamental disease mechanisms and characteristics, and greater understanding gained in one can often benefit others. To ensure we capitalise on diverse expertise, approaches and perspectives, we have established cross-centre themes.
Research themes
