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Interviews with authors of JAMA Guide to Statistics and Methods chapters about common and new statistics and methods used in clinical research and reported in medical journals.
Available episodes
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Dec 2, 2021
Case-Control Studies: Using “Real-world” Evidence to Assess Association, With Dr Irony
JAMA Statistical Editor Roger Lewis, MD, discusses Case-Control Studies: Using “Real-world” Evidence to Assess Association, With Dr Irony.
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Oct 7, 2021
Equipoise in Research—Integrating Ethics and Science in Human Research
Roger J. Lewis, MD, PhD, discusses Equipoise in Research—Integrating Ethics and Science in Human Research with Alex John London, PhD
Related Content:
Equipoise in Research—Integrating Ethics and Science in Human Research
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Sep 2, 2021
Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials
Roger J. Lewis, MD, PhD, discusses Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials with Melanie Quintana, PhD
Related Content:
* Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials
* Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial
* Incorporating Adult Evidence Into Pediatric Research and Practice: Bayesian Designs to Expedite Obtaining Child-Specific Evidence
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Aug 5, 2021
Cost-effectiveness Analysis for Clinicians
Cost-effectiveness analysis defines trade-offs between costs, harms, and benefits of alternative treatments and combines them into a single metric, the incremental cost-effectiveness ratio (ICER), that can inform decisions about which interventions to recommend when limited resources are available. Gillian Sanders-Schmidler, PhD, professor of population health sciences and medicine at Duke University, explains the method in terms clinicians can understand.
Related Article:
* Cost-effectiveness Analysis for Clinicians
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Mar 4, 2021
Multiple Comparison Procedures from the JAMA Guide to Statistics and Methods
JAMA Deputy Editor Edward Livingston, MD, discusses "Multiple Comparison Procedures" with Dr. Jing Cao, PhD
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Jan 7, 2021
Logistic Regression—What It Is and How to Use It in Clinical Research
Logistic regression is one of the most commonly used statistical analytic tools in the medical literature. William Meurer, MD, from the University of Michigan, and Juliana Tolles, MD, from UCLA, discuss a JAMA Guide to Statistics and Methods article they wrote entitled “Logistic Regression Diagnostics: Understanding How Well a Model Predicts Outcomes.”
Related Article:
Logistic Regression
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Dec 3, 2020
Randomization in Clinical Trials from the JAMA Guide to Statistics and Methods
Roger J. Lewis, MD, PhD, discusses Randomization in Clinical Trials from the JAMA Guide to Statistics and Methods
Related Article(s):
Randomization in Clinical Trials
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Sep 3, 2020
The Stepped-Wedge Clinical Trial: Evaluation by Rolling Deployment
Cluster randomized trials are performed when an intervention must be delivered to a group of patients like when testing new nursing protocols on award or different means for cleaning beds on a ward. One type of cluster trials is called a stepped-wedge where every cluster in the study ultimately undergoes the intervention. How this works it is explained by Susan Ellenberg, PhD, from the Department of Biostatistics, Epidemiology, and Informatics at the University of Pennsylvania School of Medicine.
Related Article:
The Stepped-Wedge Clinical Trial
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Aug 6, 2020
Minimal Clinically Important Difference: Defining What Really Matters to Patients
JAMA Deputy Editor Edward Livingston, MD, discusses Minimal Clinically Important Difference: Defining What Really Matters to Patients with Anna E. McGlothlin, PhD
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Jul 2, 2020
Sample Size Calculation for a Hypothesis Test With Dr Lynne Stokes
One of the most common causes for problems we see in manuscripts at JAMA is an inappropriately calculated study sample size. This seemingly mysterious process is explained by Lynne Stokes, PhD, professor of Statistical Science at Southern Methodist University in Dallas, Texas.
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Jun 25, 2020
Pragmatic Trials: Practical Answers to “Real-world” Questions With Harold C. Sox, MD
JAMA Deputy Editor Edward Livingston, MD, discusses Pragmatic Trials: Practical Answers to “Real-world” Questions with Harold C. Sox, MD, of PCORI
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May 7, 2020
Cluster Randomized Trials: Evaluating Treatments Applied to Groups With William J. Meurer, MD
JAMA Deputy Editor Edward Livingston, MD, discusses "Cluster Randomized Trials: Evaluating Treatments Applied to Groups" with William J. Meurer, MD, MS
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Feb 6, 2020
Noninferiority Trials: Is a New Treatment Almost as Effective as Another? with Dr Amy Kaji
Ed Livingston, MD, FACS, AGAF, discusses Noninferiority Trials: Is a New Treatment Almost as Effective as Another? with Amy Kaji, MD, PhD
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Dec 5, 2019
JAMA Guide to Statistics and Methods
Clinical researchers and biostatisticians use highly specialized language to help them discuss statistics and research methods efficiently. In 2019 JAMA published the JAMA Guide to Statistics and Methods, a book of short reviews that translate that specialized language and explain statistics and methods to a broad physician readership. The book's editors and authors, Edward Livingston, MD, and Roger J. Lewis, MD, PhD, discuss their approach to choosing statistical topics and their objectives in compiling the reviews into book format.
Purchase the JAMA Guide to Statistics and Methods at:
McGraw-Hill: ja.ma/StatsGuideMH
Barnes and Noble: ja.ma/StatsGuideBN
Amazon: ja.ma/StatsGuideAmazon
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