JAMAVerified account

Study found mental stress–induced myocardial ischemia was significantly associated with an increased risk of cardiovascular events in patients with coronary heart diseasehttps://ja.ma/3CZuMQQ 

In a randomized trial of patients with #COVID19 and severe hypoxemia, compared with 6 mg of dexamethasone, 12 mg of dexamethasone did not statistically significantly reduce the number of days alive without life support at 28 dayshttps://ja.ma/3mYSTtx 

Among Danish public schoolchildren, maternal antidepressant Rx during pregnancy was assoc'd w statistically significantly lower standardized test scores in mathematics, albeit small differences, and no significant difference in language test scoreshttps://ja.ma/2ZHIKrS 

Among children with CAP discharged from an ED or hospital ward (within 48 hours), low-dose outpatient oral amoxicillin was noninferior to high dose, and 3-day duration was noninferior to 7 days, with regard to need for further antibiotic re-treatmenthttps://ja.ma/3w79Oge 

Study found vaccination with an mRNA COVID-19 vaccine was significantly less likely among patients with #COVID19 hospitalization and with disease progression, consistent with risk reduction among vaccine breakthrough infectionshttps://ja.ma/3mJbd9G 

Data do not support the use of aspirin or apixaban in the outpatient setting to reduce the major adverse cardiovascular or pulmonary consequences associated with symptomatic but clinically stable #SARSCoV2 infection #COVID19https://ja.ma/3mAH38y 

Study found, among critically ill adults with confirmed #COVID19, treatment with convalescent plasma had a low likelihood of providing improvement in organ support–free dayshttps://ja.ma/3k1Ge70 

Study found prior #SARSCoV2 infection was associated with lower risk for breakthrough infection among persons receiving the SARS-CoV-2 mRNA vaccines; however, the observational study design precludes direct comparison of infection risk btwn the 2 vaccineshttps://ja.ma/3w75tJT 

Study found that, among patients with STEMI, a concomitant diagnosis of #COVID19 was associated with significantly higher rates of in-hospital mortalityhttps://ja.ma/3nHwWhK 

Study suggests a potential small but statistically significant safety concern for #GuillainBarré syndrome following receipt of the @JanssenUS #COVID19 vaccine; findings considered preliminary pending analysis of medical records to establish a definitive Dxhttps://ja.ma/2ZnXCeG 

Study results do not support the use of platelet-rich plasma injections for ankle osteoarthritishttps://ja.ma/3ElyVPA 

Randomized trial among patients with in-hospital cardiac arrest found that administration of vasopressin and methylprednisolone, compared with placebo, significantly increased the likelihood of return of spontaneous circulationhttps://ja.ma/3Go8L05 

In outpatients, new prescription of tramadol, vs codeine, was significantly associated with a higher risk of mortality, CV events, and fractures, but not other outcomes; the findings should be interpreted cautiously due to possible residual counfoundinghttps://ja.ma/3DWmzNy 

In a randomized trial of patients with #COVID19 and severe hypoxemia, compared with 6 mg of dexamethasone, 12 mg of dexamethasone did not statistically significantly reduce the number of days alive without life support at 28 dayshttps://ja.ma/3pqNE7C 

In this RCT, in comatose survivors of out-of-hospital cardiac arrest, a target therapeutic hypothermia temperature of 31 °C did not significantly reduce the rate of death or poor neurologic outcome at 180 days compared with a target temperature of 34 °Chttps://ja.ma/2YWT5jj