Accepted for Publication: November 26, 2018.
Corresponding Author: Erica S. Shenoy, MD, PhD, Infection Control Unit, Massachusetts General Hospital, 55 Fruit St, Bulfinch 332, Boston, MA 02114 (eshenoy@mgh.harvard.edu).
Author Contributions: Drs Shenoy and Blumenthal had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: All authors.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: All authors.
Critical revision of the manuscript for important intellectual content: All authors.
Administrative, technical, or material support: Shenoy, Macy, Blumenthal.
Supervision: All authors.
Conflict of Interest Disclosures: Dr Macy is a partner in the Southern California Permanente Medical Group. Dr Macy has received research grants from ALK Abello, Inc. to study adverse drug reactions and has served on clinical trial safety and monitoring committees for BioMarin, Ultragenyx, and Audentes. Dr Macy reported grants from ALK during the conduct of the study. Drs Blumenthal and Shenoy report copyright on a clinical decision support tool for penicillin allergy evaluation. No other disclosures were reported.
Additional Contributions: The authors thank Erin Ryan, MPH; Yu Li, MS; Lisa L. Philpotts, BSN, MSLS; Lauren R. West, MPH; and Ronak G. Gandhi, PharmD, BCPS, for their assistance in manuscript preparation and Sheila Heitzig, JD, MNM, CAE, of the American Academy of Allergy, Asthma and Immunology, Amanda Jezek, BA, of the Infectious Diseases Society of America, and Valerie Deloney, MBA, and Kristy Weinshel, MBA, of the Society for Healthcare Epidemiology of America for their support.
Additional Information: This review, which was approved by The American Academy of Allergy, Asthma, and Immunology (AAAAI), the Infectious Diseases Society of America (IDSA), and the Society for Healthcare Epidemiology of America (SHEA), summarizes the evidence regarding the epidemiology, clinical consequences, and evaluation of patients with reported penicillin allergy.
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