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Chromoanagenesis from radiation-induced genome damage in Populus

August 25, 2021

Chromoanagenesis from radiation-induced genome damage in Populus

Image credit: Isabelle M. Henry

Topic Pages

Read the full Collection of Topic Pages published in PLOS Genetics.

Collection

08/19/2021

Research Article

EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis

Soler Beatty et al. identify a novel EGFR inhibitor, EGFRAP, which is an important limiter of tumor growth driven by oncogenic EGFR/Ras activity. They suggest that the ability of EGFRAP to functionally inhibit the EGFR pathway in oncogenic cells results from the activation of a feedback loop leading to increased EGFRAP expression.

Image credit: Jennifer Soler Beatty & María D. Martín-Bermudo

EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis

Recently Published Articles

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Current Issue

Current Issue September 2021

08/19/2021

Research Article

Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations

Liu et al. investigate the genetic basis of facial morphology using 3D facial images of an East African cohort. They find significant signals at 20 loci, which are enriched for active chromatin elements in human cranial neural crest cells and embryonic craniofacial tissue, consistent with an early developmental origin of the facial variation.

Image credit: Oleg Gamulinskiy, Pixabay

Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations

08/26/2021

Research Article

The impact of age on genetic risk for common diseases

Jiang et al. use a proportional hazards model within an interval-based censoring methodology to estimate age-varying individual variant contributions to genetic relative risk for 24 common diseases. They find evidence for age-varying relative risk profiles in nine diseases, including hypertension, skin cancer, atherosclerotic heart disease, and hypothyroidism. The predominant pattern shows genetic risk factors having the greatest relative impact on risk of early disease.

Image credit: Steve Buissinne, Pixabay

The impact of age on genetic risk for common diseases

08/16/2021

Research Article

Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction

Guo et al. investigate the neuronal and molecular mechanisms behind nutritional state-mediated regulation of gustatory perception in control of feeding behavior in the brown planthopper and Drosophila. Their findings demonstrate one nutritional state-dependent pathway that modulates sweet perception and thereby feeding behavior.

Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction

Image credit: Shun-Fan Wu

10/19/2021

Collection

Domestic Animal Genetics

Curated by and introduced with an Editorial from Associate Editor Tosso Leeb, the collection presents a selection of PLOS Genetics research that exemplifies recent progress in domestic animal genetics and areas for future development.

Domestic Animal Genetics

Image credit: Pete Linforth, Pixabay

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