We are the pre-eminent public national mutant mouse repository and distribution archive in the USA, serving as a national resource of mutant mice available to the global scientific community for biomedical research..
https://link.springer.com/article/10.1007/s00335-021-09894-0
COVID-19 is a serious public health threat and researchers around the globe are turning to mouse models as a critical tool in viral pathogenesis, vaccine, and drug treatment discovery research. To help support these efforts, the MMRRC is distributing several COVID-19 related mouse models. To learn more about the COVID-19 related list of available strains available from the MMRRC, please visit: https://www.mmrrc.org/catalog/covid_models.php
The MMRRC is now maintaining two exciting new lines with broad applicability and interest to scientists working in many different areas. These mouse lines are called “Mouse for Actively Recording Cells 1” or MARC1. Donated by Dr. George M. Church, Ph.D., and Dr. Reza Kalhor, Ph.D., of Harvard Medical School, they are used for barcoding and lineage tracing applications in the mouse (PMID:30093604). Although these lines do not express any disease-related phenotypes, when a MARC1 mouse is crossed to mice expressing cas9 (universally or in a lineage-specific manner), combinatorial and cumulative barcoding starts in the progeny during their development, leading to developmentally barcoded animals that can be used for a multitude of applications, including lineage tracing.
The available lines are:
Please contact our customer service center at service@mmrrc.org if you have any questions about these new lines.
This March during Brain Injury Awareness Month, the NIH is conducting a campaign that is aimed at educating the general public about the incidence of brain injuries and the needs of people with brain injuries. For more information on traumatic brain injuries, visit the NIH’s official website:
https://www.ninds.nih.gov/Disorders/All-Disorders/Traumatic-Brain-Injury-Information-Page
Popular MMRRC Brain Injury Awareness Month Strains:
Contact us if you need assistance with learning more about strains related to Breast Cancer in the MMRRC repository.
This February during American Heart Month, the NIH is encouraging people to take charge of their health and start new, heart-healthy behavior that can help reduce their risk of heart disease and stroke. For more information, visit the NIH’s official website:
https://www.nhlbi.nih.gov/health/educational/hearttruth/lower-risk/what-is-heart-disease.htm
Popular MMRRC Heart Month Strains:
Contact us if you need assistance with learning more about strains related to Breast Cancer in the MMRRC repository.
This month seeks to promote health and awareness of birth defects. At the MMRRC, we understand that data sharing is essential to speed translation of research results into knowledge, therapies, and procedures to improve human health. The MMRRC is committed to sharing data and offers several strains and models to advance research in structural birth defects and foster discovery of shared genetic pathways between disorders:
https://www.nichd.nih.gov/about/overview/directors_corner/prev_updates/010715-birth-defects
Popular research models available in the MMRRC include:
Contact us if you need assistance with learning more about strains related to birth defects in the MMRRC repository.
The MMRRC is pleased to welcome its newest collection of cell lines to the repository. The UC Davis/NIH NeuroMab Facility has deposited 473 Hybridoma Cell Lines into the MMRRC at UC Davis.
Hybridoma cell lines are immortal monoclonal antibody producing cells that can be grown in tissue culture at any scale to produce monoclonal antibodies. Each of the 473 cell lines in the MMRRC produced monoclonal antibodies validated for the specificity and efficacy in brain research applications at UC Davis/NIH NeuroMab Facility.
This new collection will empower researchers with the ability to produce large quantities of specific and highly validated monoclonal antibodies at low cost. One of the other benefits of having this collection in the MMRRC is that scientists also have access to knockout mouse lines for genes that encode protein targets of the NeuroMAb monoclonal antibodies. Accessibility of these cell lines will allow investigators to explore the dynamic organization of specific cell antibodies critical to understanding and improving health and disease.
Check out the new collection here
This October during Breast Cancer Awareness Month, the NIH is joining efforts across the U.S. to raise awareness, share information, and highlight research to help fight the disease. For more information on Breast Cancer, visit the NIH’s official website:
Popular MMRRC Breast Cancer Awareness Month Strains:
Contact us if you need assistance with learning more about strains related to Breast Cancer in the MMRRC repository.
This September during Prostate Cancer Awareness Month, the NIH is working to provide easily accessible prostate health screenings and to educate the public about risk factors of prostate related diseases. For more information on Prostate Cancer, visit the NIH’s official website:
https://report.nih.gov/nihfactsheets/ViewFactSheet.aspx?csid=60
Popular MMRRC Prostate Cancer Awareness Month Strains:
Contact us if you need assistance with learning more about strains related to Prostate Cancer in the MMRRC repository.
Come learn from leading scientific researchers about the latest developments and research surrounding Precision Mouse Modeling as it translates to Human Disease. Sponsored by the NIH, ORIP, this information symposium will be held from 1:30pm – 5pm on September 11 at Monsanto Auditorium of the Bond Life Science Center on the University of Missouri-Columbia.
This August during Spinal Muscular Atrophy Awareness Month, the NIH is raising a public health campaign to spread awareness of spinal muscular atrophy and the availability of carrier screening. For more information on Spinal Muscular Atrophy, visit the NIH’s official website:
https://www.ninds.nih.gov/Disorders/All-Disorders/Spinal-Muscular-Atrophy-Information-Page
Popular MMRRC Spinal Muscular Atrophy Awareness Month Strains:
Contact us if you need assistance with learning more about strains related to Spinal Muscular Atrophy in the MMRRC repository.
June is Alzheimer’s Awareness Month, and a popular research area for MMRRC strains to study the disease. For more information on Alzheimer’s disease, visit the NIH’s official website:
https://www.nia.nih.gov/health/alzheimers
Popular MMRRC Alzheimer’s Awareness Month Strains:
Contact us if you need assistance with learning more about strains related to Alzheimer in the MMRRC repository.
This May during Cystic Fibrosis Awareness Month, the NIH is encouraging the public to support their mission to cure Cystic Fibrosis by participating in walks and sharing facts about the disease on social media. For more information on Cystic Fibrosis, visit the NIH’s official website:
https://ghr.nlm.nih.gov/condition/cystic-fibrosis
Popular MMRRC Cystic Fibrosis Awareness Month Strains:
Contact us if you need assistance with learning more about strains related to Cystic Fibrosis in the MMRRC repository.
This April during Parkinson’s Awareness Month, the NIH is conducting a campaign to gain support for the one million Americans affected by Parkinson’s disease. For more information on Parkinson’s disease, visit the NIH’s official website:
https://www.ninds.nih.gov/Disorders/All-Disorders/Parkinsons-Disease-Information-Page
Popular MMRRC Parkinson’s Awareness Month Strains:
Contact us if you need assistance with learning more about strains related to Parkinson’s disease in the MMRRC repository.
This March during National Kidney Month, he NIH-NIDDK is focusing on raising that Chronic Kidney Disease is a serious condition affecting more than 30 million adults in the United States, yet people in the early stages may not have symptoms. Many people don’t find out they have kidney disease until their kidneys are permanently damaged. To learn more about Kidney Disease, visit the NIH-NIDDK’s official website:
https://www.niddk.nih.gov/health-information/kidney-disease
Popular MMRRC Kidney Disease Month Strains:
Contact us if you need assistance with learning more about the more than 320 strains related to Kidney Disease available in the MMRRC repository.
The Mutant Mouse Resource and Research Center (MMRRC), the official National Institute of Health (NIH) repository of mouse models, is pleased to announce the availability of genetically-altered mice and embryonic stem (ES) cells made as part of the NIH Knockout Mouse Project (KOMP) and previously maintained in the KOMP Repository. The KOMP Repository collection will provide investigators with the convenience of a one-stop portal to one of the largest inventories of mutant mouse strains and ES cell lines available to the biomedical research community.
These newly acquired mouse and ES cell lines have been deposited into the MMRRC at UC Davis. The MMRRC at UC Davis is the largest of four regional archive and distribution centers in the NIH consortium. The MMRRC functions as a single repository resource and is comprised of an Informatics, Coordination and Service Center (ICSC) and three additional regional distribution facilities which include: The Jackson Laboratory, University of Missouri, and University of North Carolina, Chapel Hill. The newly available KOMP Repository mice (4,175 unique lines) & ES cell lines (14,013 unique mutant lines and 7 parental lines) can be accessed by visiting the MMRRC website (www.mmrrc.org) and typing in "KOMP Repository" in the search function, or by using the advanced search function and indicating “Major Collection = KOMP", and then searching by gene of interest, which will allow filtering for ES cells or mice.
The MMRRC was created in 1999, and is supported through the NIH, Office of Infrastructure and Research Programs (ORIP), as the nation’s premier mouse archive and distribution repository. Since that time, the MMRRC has earned an international reputation for the management, cryopreservation, and distribution of scientifically valuable, genetically engineered mouse strains and mouse ES cells. In partnership with researchers around the globe, the MMRRC continues to expand its holdings of mouse models. Today, with more than 59,000 available models, the MMRRC serves as a valuable resource to drive research discoveries for human disease.
This February during American Heart Month, the NIH is encouraging people to take charge of their health and start new, heart-healthy behavior that can help reduce their risk of heart disease and stroke. For more information, visit the NIH’s official website.
https://www.nhlbi.nih.gov/health/educational/hearttruth/lower-risk/what-is-heart-disease.htm
Popular MMRRC Heart Month Strains:
Contact us if you need assistance with learning more about strains related to heart disease in the MMRRC repository.
This month seeks to promote health and awareness of birth defects. At the MMRRC, we understand that data sharing is essential to speed translation of research results into knowledge, therapies, and procedures to improve human health. The MMRRC is committed to sharing data and offers several strains and models to advance research in structural birth defects and foster discovery of shared genetic pathways between disorders.
https://www.nichd.nih.gov/about/overview/directors_corner/prev_updates/010715-birth-defects
Popular research models available in the MMRRC include:
Contact us if you need assistance with learning more about strains related to birth defects in the MMRRC repository.
The MMRRC education booth is back from two exciting end of the year conferences in San Diego: ASHG and SfN. Both conferences boasted strong attendance rates, with ASHG claiming their highest attendee count to date. There were many great poster sessions showcasing the latest research efforts involving the use of mouse models. We had the pleasure of meeting many new investigators and students and learning about their research efforts involving the use of mice. We were also excited to provide information about role that the MMRRC plays with archiving and distribution of mouse models, and the importance of rigor and reproducibility. It’s always great to see that our outreach and education efforts can have an impact on increasing awareness of the MMRRC.
#mousemodels #mouseresearch #rigorandreproducibility #NIHORIP #mouseresearchstudies #MMRRC #MMRRCMice #ASHG #ASHG2018 #ASHG18 #SFN2018 #SfN18
This November during Diabetes Awareness Month, the NIH is encouraging people to gain understanding and offer support to those dealing with the challenges of diabetes. For more information on Diabetes, visit the NIH’s official website.
https://www.nih.gov/about-nih/what-we-do/nih-turning-discovery-into-health/diabetes
Popular MMRRC Diabetes Awareness Month Strains:
Contact us if you need assistance with learning more about strains related to Diabetes in the MMRRC repository.
This October during Breast Cancer Awareness Month, the NIH is joining efforts across the U.S. to raise awareness, share information, and highlight research to help fight the disease. For more information on Breast Cancer, visit the NIH’s official website.
Popular MMRRC Breast Cancer Awareness Month Strains
Contact us if you need assistance with learning more about strains related to Breast Cancer in the MMRRC repository.
This September during Prostate Cancer Awareness Month, the NIH is working to provide easily accessible prostate health screenings and to educate the public about risk factors of prostate related diseases. For more information on Prostate Cancer, visit the NIH’s official website.
https://report.nih.gov/nihfactsheets/ViewFactSheet.aspx?csid=60
Popular MMRRC Prostate Cancer Awareness Month Strains
Contact us if you need assistance with learning more about strains related to Spinal Muscular Atrophy in the MMRRC repository.
This August during Spinal Muscular Atrophy Awareness Month, the NIH is raising a public health campaign to spread awareness of spinal muscular atrophy and the availability of carrier screening. For more information on Spinal Muscular Atrophy, visit the NIH’s official website.
https://www.ninds.nih.gov/Disorders/All-Disorders/Spinal-Muscular-Atrophy-Information-Page
Popular MMRRC Spinal Muscular Atrophy Awareness Month Strains
Contact us if you need assistance with learning more about strains related to Spinal Muscular Atrophy in the MMRRC repository.
On July 28th, during World Hepatitis Day, the NIH aspires to join people together and raise the profile of viral hepatitis among the public, the world’s media, and on the global health agenda. For more information on Hepatitis, visit the NIH’s official website.
https://www.niaid.nih.gov/diseases-conditions/hepatitis
Popular MMRRC World Hepatitis Day Strains
Contact us if you need assistance with learning more about strains related to Hepatitis in the MMRRC repository.
This June during Alzheimer’s Awareness Month, the NIH is encouraging people to learn more about Alzheimer’s, share their stories, and take action to fight the disease. For more information on Alzheimer’s disease, visit the NIH’s official website.
https://www.nia.nih.gov/health/alzheimers
Popular MMRRC Alzheimer’s Awareness Month Strains
Contact us if you need assistance with learning more about strains related to Alzheimer in the MMRRC repository.
This May during Cystic Fibrosis Awareness Month, the NIH is encouraging the public to support their mission to cure Cystic Fibrosis by participating in walks and sharing facts about the disease on social media. For more information on Cystic Fibrosis, visit the NIH’s official website.
https://ghr.nlm.nih.gov/condition/cystic-fibrosis
Popular MMRRC Cystic Fibrosis Awareness Month Strains
Contact us if you need assistance with learning more about strains related to Cystic Fibrosis in the MMRRC repository.
The MMRRC is excited to announce the upcoming release of our newly redesigned submission form set for debut on Wednesday, May 2nd 2018.
Along with user-friendly navigation the form has been significantly reduced to only include the bare minimum criteria needed for strain acceptance. The new design allows users to navigate through the submission form easily and effectively with informative tool-tips to help explain and clarify questions.
Our new shorter form will reduce completion time significantly and make multiple submissions a much simpler process. We anticipate a smooth transition over and look forward to hearing your feedback!
This April during Parkinson’s Awareness Month, the NIH is conducting a campaign to gain support for the one million Americans affected by Parkinson’s disease. For more information on Parkinson’s disease, visit the NIH’s official website.
https://www.ninds.nih.gov/Disorders/All-Disorders/Parkinsons-Disease-Information-Page
Popular MMRRC Parkinson’s Awareness Month Strains
Contact us if you need assistance with learning more about strains related to Parkinson’s disease in the MMRRC repository.
This March during Brain Injury Awareness Month, the NIH is conducting a campaign that is aimed at educating the general public about the incidence of brain injuries and the needs of people with brain injuries. For more information on traumatic brain injuries, visit the NIH’s official website.
https://www.ninds.nih.gov/Disorders/All-Disorders/Traumatic-Brain-Injury-Information-Page
Popular MMRRC Brain Injury Awareness Month Strains:
Contact us if you need assistance with learning more about strains related to brain injuries in the MMRRC repository.
This February during American Heart Month, the NIH is encouraging people to take charge of their health and start new, heart-healthy behavior that can help reduce their risk of heart disease and stroke. For more information, visit the NIH’s official website.
https://www.nhlbi.nih.gov/health/educational/hearttruth/lower-risk/what-is-heart-disease.htm.
Popular MMRRC Heart Month Strains:
Contact us if you need assistance with learning more about strains related to heart disease in the MMRRC repository.
Representatives from the MMRRC will be attending American Society of Human Genetics 2017 October 17 – 21 in Orlando FL. Please be sure to stop by our education and outreach booth and learn more about how the MMRRC can help you with your mouse related research needs.
Representatives from the MMRRC will be attending Society for Neuroscience 2017 November 11 – 15 in Washington, DC. Please be sure to stop by our education and outreach booth and learn more about how the MMRRC can help you with your mouse related research needs.
Representatives from the MMRRC will be attending Experimental Biology 2017 April 22 – 26 in Chicago, IL. Please be sure to stop by booth #1412 and learn more about how the MMRRC can help you with your mouse related research needs.
The IMPC is creating knockout mouse lines for every single protein coding gene in the mouse genome, and characterizing them through standardized, quality-controlled phenotyping tests.
Since 2006, researchers around the world have been working together to generate a targeted knockout mutation for every gene in the mouse genome. The US component of this effort, The Knockout Mouse Project (KOMP), has been providing critical tools for understanding gene function and the genetic causes of human diseases.
In 2016, the National Institutes of Health funded the next phase in the KOMP project called KOMP2 Phase 2 with the objective to produce and phenotype more than 3000 new knockout mouse lines on a C57BL6/N genetic background. Here at the MMRRC, we are pleased to announce that these KOMP2 Phase2 mouse lines will all be made available from the MMRRC repositories. New mouse lines will be added monthly and full phenotyping data will be available.
Genetically engineered mice serve as valuable models of human disease, contributing to major medical breakthroughs. Often, biomedical researchers must develop unique genetically modified strains of mice for experimentation, a costly and time-consuming process. Now, more researchers in fields from immunology to cancer may be able to save time and money by acquiring genetic material from a repository of previously engineered strains.
Representatives from the MMRRC will be attending The Allied Genetics Conference July 13 – 17 in Orlando FL. Please be sure to stop by our booth and learn more about how the MMRRC can help you with your mouse related research needs. http://www.genetics2016.org
Representatives from the MMRRC will be attending Society for Neuroscience 2016 November 13 –16 in San Diego, CA. Please be sure to stop by booth #4322 and learn more about how the MMRRC can help you with your mouse related research needs. https://www.sfn.org/annual-meeting/neuroscience-2016
Representatives from the MMRRC will be attending Experimental Biology 2016 April 2 – 6 in San Diego CA. Please be sure to stop by booth #1104 and learn more about how the MMRRC can help you with your mouse related research needs. http://experimentalbiology.org/2016/Home.aspx
Representatives from the MMRRC will be attending American Society for Human Genetics 2016 October 18 – 22 in Vancouver, BC. Please be sure to stop by booth #422B and learn more about how the MMRRC can help you with your mouse related research needs.
http://www.ashg.org/2016meeting/
Read the recently published article in Nature about how the MMRRC repository provides scientific value and utility through curation, preservation, genetic quality control, and protection from pathogens. Learn about the efforts that the MMRRC takes to help researchers reduce model redundancy and improve reproducibility of studies. http://www.nature.com/news/reproducibility-use-mouse-biobanks-or-lose-them-1.17707
Representatives from the MMRRC will be attending the 66th Annual AALAS National Meeting November 1-5, 2015 Phoenix, AZ. Please be sure to stop by booth #215 and learn more about how the MMRRC can help you with your mouse related research needs. https://www.aalas.org/national-meeting#.VRrfaE10y70
Representatives of the Mutant Mouse Regional Resource Center will be attending the American Society of Cell Biology Meeting in Philadelphia December 6-10. Please come by booth #916 and let us help you with your mouse research needs.
The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). The dkNET portal contains information about research resources such as antibodies, vectors and mouse strains, data, protocols, and literature.
The MMRRC is pleased to officially announce the release of our newly redesigned order process! Along with user-friendly navigation and the new "Favorites" feature, the order form has been updated with the latest information and a fresh new look. The new design allows users to navigate through the order process easily and effectively with alerts for missed questions, in-line hints, and the ability to alter contact information within the form. The new Favorites feature allows users to save and organize their favorite products and even allows them to send their favorites list to their registered email account for later reference.
April 26 – 30
Experimental Biology
Booth 1439
San Diego, CA, San Diego Convention Center
http://experimentalbiology.org/2014/Home.aspx
October 18 - 22
American Society Human Genetics
Booth TBD
San Diego, CA, San Diego Convention Center
http://www.ashg.org/2014meeting
November 15 – 19
Neuroscience
Booth TBD
Washington, DC, Walter E. Washington Convention Center
http://www.sfn.org/annual-meeting/neuroscience-2014
December 6 - 10
American Society Cell Biology
Booth TBD
Pennsylvania, PA, Pennsylvania Convention Center
http://www.ascb.org/meetings-home
The Mutant Mouse Regional Resource Center (MMRRC) will be attending the 2013 American Society for Cell Biology Meeting December 14 through 18 in New Orleans. The MMRRC has been able to map 900 MeSH terms from attendee publications to mouse models within our repositories. If you are attending the meeting, then please consider visiting our booth and speaking directly with one of our knowledgeable customer service staff members.
The Mutant Mouse Regional Resource Center (MMRRC) repository simple and advanced search methods now include the ability to search by associated Major Medical Subject Heading (MeSH) terms. MeSH is the National Library of Medicine\'s controlled vocabulary thesaurus. It consists of sets of terms naming descriptors in a hierarchical structure that permits searching at various levels of specificity. Major MeSH terms are defined by authors of primary research articles as having the most relevance to the research represented by the article.
The Mutant Mouse Regional Resource Center (MMRRC) will be attending the Society of Neuroscience Meeting in San Diego November 9-13 (booth 3831). Among the thousands of model systems within the MMRRC repository, the MMRRC has 440 neuroscience models in 700 major Medical Subject Heading (MeSH) categories. If you are attending the meeting, then please consider visiting our booth (#3831) and speaking directly with one of our knowledgeable customer service staff members.
The International Mouse Phenotyping Consortium is conducting a survey with the goal of exploring ways to ensure that researchers utilize high-impact mouse-model resources. The on line survey is available here.
When expressed in mice, high levels of Neuregulin 1 (Nrg1) lead to behavioral deficits and hypofunction of glutamatergic and GABAergic pathways similar to that found in human patients with schizophrenia. Don-Yin Min, et al. found that these effects are diminished when Nrg1 levels are returned to normal.
The MMRRC has related mouse models.
Evidence that that miR-146a is a downstream-mediator of 16K PRL that could potentially serve as a biomarker and therapeutic target for PPCM.
Full publiceation here.
The MMRRC has a related ES cell line.
Researchers at UT Southwestern Medical Center have identified a specific gene, Meis1 that regulates the heart’s ability to regenerate after injuries. The original article can be found in Nature.
The MMRRC has a GENSAT mouse containing multiple copies of a modified BAC in which EGFP reporter gene is inserted immediately upstream of the Meis1 coding sequence of the targeted gene.
In 2012, the MMRRC was able to successfully deliver 246 out of 247 resuscitation orders. Please consider our services to best meet your research needs.
Scientists Make Mouse Model of Human Cancer, Demonstrate Cure
UT Southwestern Medical Center scientists report the first successful blocking of tumor development in a genetic mouse model of an incurable human cancer. Blocking the activity of a receptor molecule named CXCR4 inhibited tumor development of malignant peripheral nerve sheath tumors (MPNSTs).
STOCK Tg(Cxcr4-EGFP)CD73Gsat/Mmucd is available from the MMRRC and contains multiple copies of a modified BAC in which EGFP reporter gene is inserted immediately upstream of the coding sequence of the targeted gene.
In an effort to determine MMRRC's contribution to biomedical research, we reached out to all our previous customers and asked for additional information on previous orders. Customers who filled out the raffle form with valid NIH Grant entries and/or Pubmed publication IDs were entered into a raffle with a chance to win a new iPod. The raffle winner was selected today. Congratulations to Dr. Caius G. Radu from University of California, Los Angeles for winning the iPod. We would like to thank all those who participated in this raffle and provided valuable information about their past purchases from MMRRC. We appreciate their time and effort.
Brain diseases associated with the misformed protein tau, including Alzheimers disease and frontotemporal lobar degeneration with tau pathologies, are characterized by neurofibrillary tangles (NFTs) comprised of pathological tau filaments. article Mapt at MMRRC
Our very own Terry R. Magnuson, Ph.D., Sarah Graham Kenan Professor and chair, department of genetics, and vice dean for research, School of Medicine, University of North Carolina, Chapel Hill, and Project Director for the MMRRC at North Carolina-Chapel Hill, was just elected to the Institute of Medicine of the National Academies.
Welcome to the newly revised MMRRC website! The goal of this revision is to modernize the look and feel of MMRRC's web presence. We hope the new simplified search feature will make finding the products you are looking for easier. For any questions/problems you have regarding this release, please email us at service@mmrrc.org, or use the Feedback function to the right side of the page.