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- I Will Survive Inc.
- I'm Taking Charge
- i-tri - Inspirational Triathlon Racing International
- I.M. Sulzbacher Center for the Homeless, Inc.
- iACT
- Ian Somerhalder Foundation
- IBSA, Inc.
- ICAN, International Cancer Advocacy Network
- ICAN: Positive Programs for Youth
- iCast International Center for Appropriate & Sustainable Technology
- Icing Smiles
- ICNA Relief USA
- Idaho Drug-Free Youth Inc
- Idaho Lions Sight and Hearing Foundation
- Idaho Meth Project Inc
- Idaho Nonprofit Center
- iEARN-USA (International Education and Resource Network)
- IFMA Foundation
- Ignatian Solidarity Network
- Ignatian Volunteer Corps
- IGY6 Service Dogs for Heroes
- IHS, The Institute For Human Services, Inc
- IKAR
- ILLINOIS ASSOCIATION OF RETIRED FIREFIGHTERS
- Illinois Birddog Rescue Inc
- Illinois Blessing NFP
- Illinois Doberman Rescue Plus
- Illinois Equine Humane Center Nfp
- Illinois Fire Safety Alliance
- Illinois Horse Rescue of Will County
- Illinois Leadership Seminars (ILS)
- Illinois Police Association Inc
- Illinois Technology Foundation
- Illuminate Heart, Inc.
- Illumination Foundation
- Image Reborn Inc
- Images of the Motherland Interactive Theater
- IMAGES ON THE RISE
- Imagination Theater Inc
- Imagine Children's Health Center
- Imagine Foundation for Kids
- Imagine Missoula
- Imagine Nations Inc
- Imagine Scholar
- IMAHelps
- Imani House Inc
- Immaculate Heart Central Schools
- imMEDIAte Justice
- Immigrant Learning Center Inc
- Immigration Advocacy Services Inc
- Immigration Equality
- Immune Deficiency Foundation
- Immunization Collaboration of Tarrant County
- Imo People Development Foundation
- Impact 100 Inc
- Impact Austin
- Impact Austin Foundation
- Impact Bay Area
- Impact Network
- Impact On Education
- Impact Personal Safety, SoCal
- Imua Family Services
- In A Perfect World Foundation
- In Arms Reach Inc
- In Defense of Animals
- In Harmony With Nature animal haven
- In Ian's Boots, Inc.
- In My Fathers Kitchen
- In Need of Diagnosis
- In Our Hands Rescue
- In Our Hands Rescue
- In Search Of Genius Foundation
- In The Gap Inc
- In the Pink Boutique Inc
- In Touch Ministries Inc
- In-Sync Exotics, Inc.
- In2Books (ePals Foundation)
- INCIID Inc (InterNational Council on Infertility Information Dissemination, Inc.)
- Include Autism
- Incred-A-Bull
- Indego Africa
- Independence First, Inc.
- Independent Cat Society
- Independent Cat Society Inc.
- Independent Living, Inc.
- India Development and Relief Fund Inc
- India Gospel League, Inc. North America
- India Literacy Project
- India Partners
- Indian Dreams Foundation
- Indian Women and Child Welfare Trust
- Indiana Center for Middle East Peace
- Indiana Parkinson Foundation
- Indiana Petite Paws Rescue Angels, Inc.
- Indiana Regular Baptist Youth Camps Inc
- Indianapolis Early Learning Center
- Indianapolis Neighborhood Housing Partnership Inc
- Indicorps
- Indigo Mountain Nature Center, Inc.
- Indigo Rescue