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- O'Brien School for the Maasai NFP
- O.A.B.I.: Organization for Abused and Battered Individuals
- Oahu Society for the Prevention of Cruelty of Animals
- Oak Crest Institute of Science
- Oak Crest Village Inc
- Oak Hill Animal Rescue Inc
- Oak Lake Art Center
- Oak Park River Forest Food Pantry
- Oak Tree Corner Inc
- Oakland Asian Cultural Center
- Oakland Digital Arts & Literacy Center (ODALC)
- Oakland Kids First
- Oakland Livingston Human Service Agency
- Oakland Planning & Development Corporation
- Oakland Youth Chorus
- Oaks Family Care Center Inc
- Oasis Animal Shelter
- Oasis Compassion Agency Inc
- Oasis Counseling For Women And Children
- Oasis Ministries for Spiritual Development
- Oasis Sanctuary Foundation, Ltd.
- OATS, Inc.
- Oaxaca Street Children Grassroots, Inc.
- Obat Helpers Inc
- Ocala Foursquare Church
- OccuPaws Guide Dog Association
- Ocean Blue Project INC
- Ocean Defenders Alliance
- Ocean Rehab Initiative Inc
- Ocean River Institute Inc
- Ocean State Theatre Company Inc
- OceansWatch
- Ochan Self-Help Alliance, Inc.
- Octarium
- ODIM - Guatemala
- Of One Accord
- Off the Wall Productions
- Offcenter Community Arts Project
- Offender Aid and Restoration of Arlington County (OARA), Inc.
- OfficerDown.US
- Ohana Rescue Inc.
- Ohio Alliance For Arts Education
- Ohio Citizen Action
- Ohio Environmental Council
- Ohio House Rabbit Rescue Inc
- Ohio Newsboys Association Inc
- Ohio Society for the Prevention of Cruelty to Animals Inc.
- Ohio Valley Goodwill Industries Rehabilitation Center Inc
- Ohlone College Foundation
- OIC OF ANNE ARUNDEL COUNTY INC
- Ojai Valley Whale Society
- OK Save A Dog
- Okaloosa Walton Homeless Continuum of Care Opportunity, Inc.
- Okizu
- Oklahoma Arts Institute at Quartz Mountain
- Oklahoma Baptist Homes For Children Inc
- Oklahoma Community-Based Providers Inc
- Oklahoma Humane Society
- Oklahoma Life Skills Association: Special Kids
- Oklahoma Performing Arts
- Oklahomans For Equality Inc
- Olancho Aid Foundation Inc
- Olathe Civic Band Inc
- Old Church Ministries, Inc.
- Old Colony Montessori School Inc
- Old Dominion Performance Arts Studio Inc.
- Old Friends Inc
- Old Guard Riders Inc
- Old Pine Farm Natural Lands TR Inc
- Old Skool Cafe
- Oldies But Goodies (OBG) Cocker Rescue
- Olympia School District Education Foundation
- Olympic Animal Sanctuary
- OM Foundation (OMF)
- Omaha Healthy Kids Alliance
- Omni Youth Programs
- Omprakash
- On Angels Wings Inc
- On Course Foundation USA
- On My Way Home Rescue
- On Point For College Inc
- On The Right Trail Horse Rescue Inc
- On Your Feet, Inc.
- On-The-Move Community Integration
- OnBehalf.org
- One Acre Fund
- One Brick
- One By One
- One Circle Inc
- One Common Unity
- One Day's Wages
- ONE Freedom Inc
- One Heart Bulgaria
- One Heart Source
- One Hope Ministries NFP
- One Horse At A Time, Inc
- One Iowa Education Fund
- One Life
- One Life Alliance Inc
- One Love 4 Kids