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- Spay-Neuter Assistance Program, Inc.
- Spay-Neuter Services of Indiana
- SPCA for Monterey County
- SPCA International
- SPCA of Franklin County
- SPCA Tampa Bay
- spcaLA
- SPEAK
- Speak Out Against Bullying, Inc
- Speak Up For Horses Inc
- SpeakeasyDC
- Special Angel Inc
- Special Equestrian Riding Therapy Inc
- Special Equestrians Inc.
- Special Forces Assn
- Special Horses
- Special Medical Response Team
- Special Olympics Massachusetts Inc
- Special Olympics Michigan Inc
- Special Olympics Southern California Inc
- Special Operations Warrior Foundation
- Special Populations Tennis Program Inc
- Special Spaces
- Special Surfers
- Spectordance
- Spectrum Charter School Inc
- Spectrum Designs Foundation Ltd.
- Speech and Language Development Center
- Speedway Angels
- Spendsmart Inc
- Spertus Institute for Jewish Learning and Leadership
- Sphoorti Foundation
- Spikenard Farm Honeybee Sanctuary
- Spina Bifida Association of America
- Spina Bifida Association of Western Pennsylvania
- Spirit Acres Farm Equine Rescue and Sanctuary
- Spirit Jump
- Spirit Key Inc
- Spirit Led Ministries
- Spirit of Blue Foundation
- Spirit of Sharing (SOS)
- Spirit Open Equestrian Program
- Spirit Rock Meditation Center
- Spirit Therapies
- Spirithorse Therapeutic Riding Center
- Spiritual Life Center Inc
- Spirituality For Kids International Inc
- Spoiled Acres Rescue Inc
- Spokane Hope School Hearing-Oral Program of Excellence
- Spondylitis Association of America
- Sporting Woman Community Fund
- Sportsgrants Inc
- Spotlight Kids Theatre Inc
- Spotlight Youth Theatre
- Spreading the Love of Jesus Ministry
- Spring Creek Horse Rescue
- Spring Mountain Benefit Corp
- Spring Reins of Life Inc.
- Spring Street CDC (SOAR, C.H.A.N.G.E. Fitness, Table of Hope)
- Springboard Enterprises
- Springboard Forward
- Springfield Rescue Mission, Inc.
- Springfield Victory Mission Inc
- Springs of Hope Kenya Inc
- Sprites Humane Education and Research Organization Inc.
- Sprout Inc
- SPUR
- SQ Foundation
- Square Care Ministries Inc.
- Square Foot Gardening Foundation
- Square Peg Foundation
- Squash Smarts Inc
- Sree Prayukti Seva Trust
- SSEP
- Ssubi Foundation aka Ssubi is Hope
- St Ann Center for Intergenerational Care, Inc
- St Annes Center Inc
- ST ANNES GUEST HOME
- St Augustine School Alumni International Inc
- St Catherine University
- St Croix Falls Festival Theatre
- St Croix Valley Foundation
- St Croix Valley Restorative Justice Program, Inc.
- St Francis All Creature Rescue And Sanctuary
- St Francis Animal Rescue Of Venice Inc
- St Francis Horse Rescue & Retirement Farm Inc
- St Francis Society Animal Rescue
- St Johns Bread & Life Program Inc
- St Joseph Apache Mission
- St Joseph Center
- St Joseph Orphanage
- St Judes Ranch for Children Inc
- St Labre Indian School
- St Louis Language Immersion Schools Inc
- St Louis Learning Disabilities Association Inc
- St Louis Senior Dog Project
- St Madeleine Sophies Training Center
- St Mary Catholic Central High School
- St Paul Elder Services Inc
- ST PAULS SOUP KITCHEN INC