MPS

MPS, M.P.S., MPs, or mps may refer to:

Manufacturing

Science

Computing, mathematics, and statistics

Maroteaux–Lamy syndrome

Maroteaux–Lamy syndrome (also known as mucopolysaccharidosis type VI, MPS VI, or polydystrophic dwarfism) is a form of mucopolysaccharidosis caused by a deficiency in arylsulfatase B (ARSB). It is named after Pierre Maroteaux (1926-) and his mentor Maurice Emil Joseph Lamy (1895-1975), both French physicians.

History and symptoms

Children with Maroteaux–Lamy syndrome usually have normal intellectual development but share many of the physical symptoms found in Hurler syndrome. Caused by the deficient enzyme N-acetylgalactosamine 4-sulfatase, Maroteaux–Lamy syndrome has a variable spectrum of severe symptoms. Neurological complications include clouded corneas, deafness, thickening of the dura (the membrane that surrounds and protects the brain and spinal cord), and pain caused by compressed or traumatized nerves and nerve roots.

Signs are revealed early in the affected child's life, with one of the first symptoms often being a significantly prolonged age of learning how to walk. By age 10 children have developed a shortened trunk, crouched stance, and restricted joint movement. In more severe cases, children also develop a protruding abdomen and forward-curving spine. Skeletal changes (particularly in the pelvic region) are progressive and limit movement. Many children also have umbilical hernia or inguinal hernias. Nearly all children have some form of heart disease, usually involving valve dysfunction. An enzyme replacement therapy, galsulfase (Naglazyme), was tested on patients with Maroteaux–Lamy syndrome and was successful in that it improved growth and joint movement. An experiment was then carried out to see whether an injection of the missing enzyme into the hips would help the range of motion and pain. At a cost of $365,000 a year, Naglazyme is one of the world's most expensive drugs.

Mandarin Phonetic Symbols II

Mandarin Phonetic Symbols II (國語注音符號第二式), abbreviated MPS II, is a romanization system formerly used in the Republic of China (Taiwan). It was created to replace the complex tonal-spelling Gwoyeu Romatzyh, and to co-exist with the popular Wade-Giles (romanization) and Zhuyin (non-romanization). It is sometimes referred to as Gwoyeu Romatzyh 2 or GR2.

History

Based on the earlier and more complex Gwoyeu Romatzyh, the tentative version of MPS II was released on May 10, 1984, by the Ministry of Education. After two years of feedback from the general public, the official version was established on January 28, 1986. To distinguish Zhuyin from the Mandarin Phonetic Symbols II ("Mandarin Zhuyin Symbols II"), the first Zhuyin is officially called "Mandarin Phonetic Symbols I" (國語注音符號第一式).

Despite its official status for almost two decades until it was replaced by Tongyong Pinyin in 2002, MPS II existed only in some governmental publications (such as travel brochures and dictionaries). However, MPS II was not used for the official Romanized names of Taiwanese places (though many road signs replaced during this period use MPS II). It never gained the same status as did Wade-Giles. In mainstream overseas communities, it is virtually unused and unheard of.