Despite the shows central conceit being about normal humans trying to bring down a God, the show has introduced a surprisingly large amount of ways that could potentially kill Homelander. In fact, more ways than there have been seasons.
I've put together a list of ways that could maybe kill him. I don't think any of these are guaranteed successes, and a few are outright unlikely and I almost didn't include, but here's a list:
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The virus, although the side effects will kill everyone. The scientist seemed to have a very specific quantity in mind, suggesting they have some reason to believe it would actually work.
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Soldier Boy: strip HL of his powers then blow his brains out. May not even require SB. Military could use Temp V on soldier after soldier until they find someone with the same power.
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Cate: touch HL, tell him to kill himself. A Train could just pick her up, arm outstretched, and run her arm into HL
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Newman: blow his head up
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Brute force: surprisingly, Maeve pierced his body. Get an army of Supes and Temp V soldiers and get to work
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Brute force 2: Tek Knight was one of the most powerful Supes due to a suit. The above could maybe be done simply with an army of super suits?
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Nuke: this one has been debated a lot. But if Maeve can hurt him, surely a nuke could?
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Make another Homelander, or maybe Ryan surpasses him
Thoughts? Any more I missed? What do you think is most and least likely to work?