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[–]berniemyfriend1 686 points687 points  (40 children)

I'm from Ireland and was just listening to the radio covering this Irish pause.

They had a doctor on from the National Immunisation Advisory Committee, which made this decision to pause use of Astra Zeneca.

She addressed the frequency question, she said its not the blood clots themselves that are the problem, since blood clots are common when dealing with millions of people. But she said the type of blood clots reported in Norway is a cause of concern.

She said they were Brain blood clots which is rarer type of blood clot and were major clots as opposed to minor ones. And she said the age of the people reporting it was people in their 20's and 30's also a rare group to be reporting blood clots.

It's because of that information they decided to pause the supply of AstraZeneca.

[–]espereia 132 points133 points  (0 children)

Thank you for clarifying this. Super important distinction ! This info should be more prominent....it’s not just clots, but brain blood clots in young people

[–]forgotten_airbender 41 points42 points  (2 children)

This should be higher up

[–]Instant_noodleless 2 points3 points  (0 children)

Thank you for the clarification.

[–]freddiequell15 13 points14 points  (11 children)

young ppl in 20's and 30's are already recieving vaccines?

[–]TheBubbleSquirrel 12 points13 points  (1 child)

If you work in healthcare, then yes.

[–]jl45 658 points659 points  (154 children)

As of 9 March 2021, 22 cases of thromboembolic events had been reported among the 3 million people vaccinated with COVID-19 Vaccine AstraZeneca in the European Economic Area.

[–]green_flash 238 points239 points  (42 children)

Also worth noting the statistics from the UK with about 10 million doses of each vaccine administered:

Reaction Cases (Pf-Bi) Deaths (Pf-Bi) Cases (AZ) Deaths (AZ)
Pulmonary embolism 15 1 13 1
Pulmonary infarction 1 0 1 0
Pulmonary thrombosis 1 0 0 0
Immune thrombocytopenia 9 0 22 1
Thrombocytopenia 13 1 12 0
Cerebral venous sinus thrombosis 1 0 3 0
Superior sagittal sinus thrombosis 0 0 1 0

Sources:

This safety update report is based on detailed analysis of data up to 28 February 2021. At this date, an estimated 10.7 million first doses of the Pfizer/BioNTech vaccine and 9.7 million doses of the Oxford University/AstraZeneca vaccine had been administered.

EDIT: Added cases for thrombocytopenia and sinus thrombosis because these are apparently the conditions of concern.

[–]LadySerrax 212 points213 points  (25 children)

The pause is most likely due to the incidents in Norway and Denmark. In Norway, three healthcare workers got blood clots in atypical places, thrombocytopenia and bleeding after getting the AstraZeneca vaccine this week. They're all hospitalised and in serious condition.

It might be unrelated, but considering there are three of them, in a tiny country, with incredibly rare conditions, right after being vaccinated, it needs to be investigated. Perhaps it was a disaster-batch. In which case they need to track down where the remaining doses are. Or perhaps the shots were set wrong, directly into the blood stream for instance. We don't know. So it's the sensible thing to pause the use of AstraZeneca until we have answers.

Source (in Norwegian, sorry. Please use google translate. Steinar Madsen is from Norways equivalent of the FDA, and NRK is one of our main news outlets, so there's luttle reason to believe it's fake news) https://www.nrk.no/norge/tre-helsearbeidere-innlagt-med-blodpropp-_-undersoker-sammenheng-med-koronavaksine-1.15416231

[–]green_flash 30 points31 points  (22 children)

Blood clots are not an incredibly rare condition. 1 in 1,000 people suffer from one every year. Immune thrombocytopenia is somewhat rare, although there appear to be other causes for thrombocytopenia and I don't know how rare they are.

[–]LadySerrax 171 points172 points  (17 children)

Yeah. But having both of those conditions happen at the same time, in three people, the same week, working in the same profession, in the same region, who all got the vaccine directly prior to the symptoms. The odds of that are astronomical.

[–]Spoonshape 11 points12 points  (0 children)

Specifically the clots happened in the brain which is far rarer. There's also the blood brain barrier which normally protects the brain from a lot of things which makes this quite strange.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292164/

[–]AngelOmega7 48 points49 points  (5 children)

To me it sounds like a high probability of an environmental factor interacting with the vaccine.

If three people working jn the same region, in the same profession, get the same vaccine and then all have the same symptoms in the same week, yet those symptoms don’t normally seem to show up with any regularity in the general population after receiving the vaccine?

I’m thinking environmental factor.

[–]LadySerrax 61 points62 points  (3 children)

Could be. Warrants an investigation either way. It does mean they most likely got a vaccine from the same batch too, so they can't rule out a contaminated batch. But it could of course also be something else in combination with a regular vaccine. In both of these instances, they need to figure out what went wrong, so it doesn't happen anywhere else. These were young people, and not high risk 90yearolds..

[–]Jacc3 3 points4 points  (0 children)

Could be a bad batch, which would explain why these issues haven't shown up elsewhere. Or just chance.

The thing is, we do not know. And that's exactly why we need to investigate it, to get answers. Not taking potential side effects seriously could be devastating for public trust in vaccines. The Nordics still remember the Swine flu vaccine.

[–]Bosco_is_a_prick 4 points5 points  (0 children)

They are a lot rarer in people under 50 which the 3 and Norway were.

[–]curious_hermit_ 38 points39 points  (0 children)

Thanks for posting that detailed information. It helps put things in perspective.

[–]Rare_Southerner 3 points4 points  (1 child)

Wow I didn't know it was possible to place a table in a comment. Thanks for the info as well (:

[–][deleted] 111 points112 points  (3 children)

Njeh, I’m fine. I’m taking a fourth-generation pill every night.

[–]da_guy2 320 points321 points  (68 children)

That's below what we'd expect for the general population, so what's the issue? If they suddenly reported that 200 people got into a car accident after having the vaccine would we pull it? No of course not. Thromboembolic events happen I'm only worried if they're happening at a rate that's unusual and 22/3 million is not unusual.

[–]Geekos 32 points33 points  (1 child)

Maybe it's young and healthy people it has happened to. Then I would be concerned as well.

[–]Talruiel 45 points46 points  (0 children)

I know the 3 in Norway, which is the reason for why its stopped in Norway for now, was 3 young healthy nurses/doctors. And it makes sense to investigate it further first, when 3 healthy people suddenly get the same serious health condition.

[–]EdmundGerber 87 points88 points  (22 children)

You are correct - but that said - what are the numbers for clots for the other three major vaccines available - Pfizer, Moderna, and J&J? I'd heard of some having allergic reactions - most likely due to PEG, but nothing beyond that.

[–]green_flash 73 points74 points  (1 child)

For Pfizer-BioNTech there are a couple more reports of blood clots, but not statistically significant, see my comment here.

[–]EdmundGerber 2 points3 points  (0 children)

Thank you. Very helpful

[–]Heregoessomethong 17 points18 points  (3 children)

I was thinking the same thing, but I think it's more complicated than that. It's not 22/3 million because only 22 have been found, but not all 3 million people have been checked for blood clots, right? So an investigation would involve checking more vaccinated people to make sure they have a good sample size of people who have been checked and confirmed to not have blood clots?

[–]da_guy2 19 points20 points  (0 children)

Yes but do we go around checking people every day for blood clots? No, they only get found when they cause a medical issue. Same thing with these. I'm not saying it isn't with looking into, but that can happen while continuing to vaccinate. We know covid is deadly, delaying vaccinations will undoubtedly lead to unnecessary deaths, so if you're proposing delaying the vaccinations you had better have overwhelming evidence the vaccine is causing the problems, and from what they're telling us right now they don't have that evidence.

[–]Gruffleson 4 points5 points  (0 children)

On the contrary, given the talk abot side-effects from the start, I will assume more issues are reported that would have been ignored if the person not recently had been vaccinated.

[–]Dotlinefever4 52 points53 points  (5 children)

And how many women on birth control pills come down with blood clots a year?

Is it still around 1 out every 1100 women?

[–]mainzelmaennchen 12 points13 points  (1 child)

Would be interesting to have some information on the predominant BMIs of those who developed blood clots after the vaccine.

The combined pill is not recommended for obese people (or smokers) for a reason.

[–]TruthBites2 21 points22 points  (3 children)

So that's a 0.00073% chance of developing a blood clot, what's the chance of getting one naturally?

[–]aaaaaaaarrrrrgh 2 points3 points  (0 children)

How many cases of thromboembolic events are expected among 3 million people of the same age in the same timeframe?

[–]Gr1mwolf 9 points10 points  (2 children)

Jesus, does such a small number even fall outside the normal occurrence? Why is Ireland assuming it was caused by the vaccine?

With odds that low, I wouldn’t care if the vaccine was causing it.

[–]epeeist 16 points17 points  (0 children)

The absolute number is small - what's worrying about the Norwegian cases is that they occurred in three fit, healthy under-45s who had no underlying risk factors for blood clots (rather than to people who had a high background risk, and who therefore were at risk of presenting with stroke or pulmonary embolus in any typical three-week period.)

[–]Serialconsumer 1317 points1318 points  (318 children)

Makes me uncomfortable that the vaccine that has taken the most ethical approach in terms of cost seems to be constantly receiving the most objections. Which for the most part seem to be later declared as unfounded.

[–]SecondAccount404 1408 points1409 points  (183 children)

The number of people with blood clots hasn’t exceeded what you would expect from any random section of humanity. Its utterly insane entire governments are now basing policy off facebook hysteria.

[–]mwagner1385 470 points471 points  (52 children)

And this is how vaccines gave my children autism came to be.

[–]whatisthishownow 447 points448 points  (35 children)

Nope. It was a malicious smear campaign. The original paper (since retracted) claimed a specific vaccine tech caused autism. The author, as you might guess, had ties to a competing vacine tech. This ironically made it a pro-vacine conspiracy...

[–]tskir 198 points199 points  (32 children)

Who's to say that what's happening to the AstraZeneca vaccine isn't a malicious smear campaign?

[–]Hendlton 20 points21 points  (11 children)

Russia?

[–]pignans 55 points56 points  (4 children)

Wouldn't be surprised, they have a history of this kind of interference and Russia are using their own vaccine to project soft power. But the AZ vaccine has also received uncharacteristically negative press as a result of its association with EU-Brexit politics, which is another a factor.

[–]HW90 8 points9 points  (0 children)

It would be an interesting choice though given that they want to do trials on combining the AZ vaccine with Sputnik V, and that they are based on very similar technology. Sputnik V has given them a lot of international clout, with the AZ combo having the potential to improve that considerably more so it would be odd for them to jeopardise such an easy win.

China on the other hand has a lot more interest in their vaccines succeeding and others failing, and also in the Pfizer vaccine succeeding because that is being manufactured in China and presumably comes with a tech transfer to help mRNA vaccine production.

[–]FarawayFairways 9 points10 points  (0 children)

It began with the New York Times and was embraced by Europe about 6 months later

[–]Kaldenar 4 points5 points  (1 child)

Pfft, try a competitor in the market.

[–]aussie_bob 4 points5 points  (0 children)

Yeah, the state actor thing is typical misdirection. This is about money, and it's something the WHO has already noted as an obstacle to manufacturing enough vaccines.

What's happening now is that each vaccine can only be made by a a single patent rights holder, most of whom are struggling to scale their output fast enough.

The right way to do it would be to open-source the vaccine manufacturing process and allow anyone who can make it to the standard to so so. Most of the vaccines were developed with taxpayer money, so that would also be the ethical thing to do - as it stands we're paying twice.

https://theconversation.com/covid-19-vaccines-open-source-licensing-could-keep-big-pharma-from-making-huge-profits-off-taxpayer-funded-research-145898

[–]ThePhantomPear 45 points46 points  (7 children)

I already had autism, after vaccination I have SUPER autism.

[–]vinoa 11 points12 points  (2 children)

Weaponized Autism?

[–]ThePhantomPear 4 points5 points  (1 child)

No that's when the 5G signals come online and the nanomachines try to take over an autist. They didn't expect autists to reprogram them for high-speed regeneration. That's when we will storm Area 51.

[–]MsEeveeMasterLS 2 points3 points  (0 children)

A large part of where that came from is people saw a big jump in the number of kids with autism but the vast majority of that jump can be explained by the fact that the diagnosis of autism has been broadened so much. I have ADD and when I was little I wasn't counted as autistic. But with how much they broadened the diagnosis of autism now I am counted as being part of the autism spectrum. That also explains the misconception that eating animals grown with growths hormones causes autism.

[–]hp0 31 points32 points  (0 children)

Out of interest do you know if that includes level of population risk.

As this in itself is an interesting point. The UK has injected a huge proportion of the population. 30% but they have concentrated on the exact population at higher risk of clotting.

Myself included. Age and history of heart failure diabetes etc will all dramatically increase the risk of clotting in a person. Along with other things that will put you in the priority list.

And the UK has verymuch concentrated on that segment of the population haveing already covered a huge %.

Technically the numbers should be higher then a random population survey.

[–]betafish2345 49 points50 points  (7 children)

I just wanted to add on this.. I'm looking at this and 22 people out of 3 million developed blood clots after getting the vaccine which you'd probably also see in the control group. You have to look at these situations on an individual basis instead of jumping to conclusions. It reminds me of Facebook hysteria I was reading a few months ago about some elderly people dying after getting the vaccine but it was proportional the amount of elderly people who generally die.

[–]pmmbok 4 points5 points  (0 children)

Yes. Dvt in younger people usually has an identifiable cause. Were the vaccine assoc cases "mysterious", or did he fall off his bike, hurt his leg, and lay around too long?

[–]polymute 80 points81 points  (26 children)

Source? My mother was vaccinated with AZOxford a few days ago, so I would be happier if I could get that.

Edit: Thx, everyone!

[–]SecondAccount404 87 points88 points  (25 children)

The European Medical Regulator

(This source wasn't originally included in my first comment, I edited it in after this reply)

[–]knud 40 points41 points  (0 children)

Sounds like you are the Facebook hysteric this time. It was paused in Denmark at the recommendation of Sundhedsstyrelsen. Not the government. What you are advocating is that the government overrules recommendations from their own agency on this matter.

[–]illBeYourBountyJubal 39 points40 points  (1 child)

Politics is scaremongering.

[–]brunes 14 points15 points  (0 children)

Er... A large portion of the COVID response in every country worldwide has been a lot more politics based than science based. So not sure why this would surprise you at all.

[–]josefx 2 points3 points  (0 children)

They mention that in the article, they also mention that they are basing this decision on what they consider several unusual cases.

[–]juan-love 9 points10 points  (0 children)

Its vaccine politics and it damages trust in vaccines which makes it moraly reprehensible

[–]Lashay_Sombra 23 points24 points  (2 children)

Main cause is Politics, it's viewed as the "British vaccine", even worse the Brits are fast outpacing the EU in their rollout, hell they were even before they approved the AZ vaccine (using Pfizer) as they approved it weeks earlier.

All the dramatics about delivery to EU in Feb? All the manufacturers were under delivering, but only one they kicked up a storm about was AZ. And now the constant scaremongering over it has hit public confidence, slowing the roll out even more as people refuse the AZ.

[–]chrisdmc 2 points3 points  (0 children)

Yes because of the pharma lobby. Welcome to the world where even a pandemic gets milked for every penny

[–]ironmenon 55 points56 points  (45 children)

ethical approach in terms of cost

While that's very nice, the the trials and development have also been very problematic and the company hasn't exactly been covering itself in glory in Europe. It's perfectly understandable why it's seeing the most issues.

[–]StealthyUltralisk 308 points309 points  (28 children)

Things like the contraceptive pill raise the risk of blood clots too and people don't go all conspiracy nut over those. Also doesn't covid itself cause blood clots in some people?

It's good they are investigating (as they should) but they should be more careful about panicking people when it comes to this, so much more damage could be done.

[–]green_flash 121 points122 points  (7 children)

Also doesn't covid itself cause blood clots in some people?

Not just some people. According to this study from NYC some form of blood clot occurred in 16% of hospitalized COVID-19 patients. Among ICU patients, 29.4% had a thrombotic event.

The corresponding number for the AstraZeneca vaccination is somewhere around 0.0001% according to statistics from the UK.

[–]StealthyUltralisk 31 points32 points  (3 children)

Wow, those are some stats. I despair at the people in charge.

[–]Tams82 12 points13 points  (1 child)

It's very worrying when people in power act like on Facebook or here.

At least on reddit being wrong leads to nothing pointless karma going up or down.

[–]Sproutykins 19 points20 points  (1 child)

Conspiracy nut? People are fucking scared. Just because you were privileged enough to receive an education on how vaccines or the scientific method work doesn’t mean that everybody else has, nor has the time to. The people who get hooked on conspiracies are trying (though failing horrendously) to educate themselves. Considering it’s usually boomers who lived through the thalidomide scandal and opioid crisis, why would they not be wary? We need better public health education, rather than mockery and alienation. It very much appears not to be working, although it’s only recently that social media has clamped down on this BS. May be a case of too little too late.

[–]ConanDanrom 3 points4 points  (0 children)

Add to that mistrust in the media. For example, when I heard about Ireland pausing Astrazeneca roll-out, I googled it and I read a NYT article that didn't mention anything about the type of clothes that happened in the reported cases and that it happened to younger people which is statistically higher than in a random group.

[–]venom259 67 points68 points  (10 children)

It's 22 cases out of over 3 million. The response as of right now seems to be a case of unfounded hysteria.

[–]Sinity 5 points6 points  (4 children)

Things like the contraceptive pill raise the risk of blood clots too and people don't go all conspiracy nut over those. Also doesn't covid itself cause blood clots in some people?

Yep. People don't have a sense of scale or any willingness to do a risk/benefit analysis. Which kills people. A lot of people. Like, variance of 22 covid deaths in a day isn't even noticeable to people - and we're talking deaths. People are able to weight, say, 10 people dead because of an intervention like a vaccine - as the same as a million deaths of covid. Or maybe 100K.

If we had a hypothetical vaccine which we knew would overall cause death on 1000 people but stop the covid - which would otherwise kill another million... people would generally choose to not start vaccinating. Which is insane.

The most ridiculous thing about covid is that our tech is actually almost an overkill for the scenario. Yet 2020 happened, and it's not even over yet.

Moderna vaccines were developed in January 2020. 2 days after there we had virus genome sequenced. It was actually done. It's the same thing which is now deployed. People might imagine scientists worked hard to 'invent' a vaccine for months. It's simply not true.

The year was just for checking if it works and is safe. Which it does. We've done great tests, all of the procedures and whatnot. Meanwhile, the world was in chaos for an entire year and millions of people died.

I'm not an expert. But I've seen an explanation of what vaccine's RNA and there isn't that much to it. Tech was clearly ready. There wasn't much to figure out. We have sequencing tech, so we had virus genome. We identified which part makes the spike. Some knowledgeable people programmed the vaccine RNA - they knew exactly what they were doing. Then, we had the tech to produce it.


All I'm saying is, if people were remotely rational and our civilization wasn't so hopelessly paralyzed, barely able to move... we could've done some animal tests to check if it isn't immediately apparent it's dangerous. Then just vaccinate 1000 young people and infect them. Check effectiveness that way. There would be volunteers, or at worst paid ones. It'd take a month.

'Unethical'? I don't agree if there's informed consent. And double blind trial, where some people don't receive protection is also iffy if that is considered iffy.

Or don't infect, just check safety and hope it is effective. Clearly they must've had a reasonable confidence it would work if they put it through the trials.

But we can't do it. We just can't. Safetyism. Lack of thinking. Eh.

[–]aza-industries 510 points511 points  (94 children)

I found out today my auntie is anti-vax, as well as a conspiracy theorist. On a call to wish me happy birthday.

I also happen to be immunocompromised.

Growing up and realising a lot of the adults you remember from childhood aren't as awesome as you thought sucks.

Edit: thank you all for your replies, I read them all.

Edit 2: A few of you sure like to infer a lot from the little bit I posted. No this doesn't just pertain to the covid vaccine, and she's also anti-medication apparently. She also doesn't believe 500,000 people died from it in the US.

It was half an hour of me trying to steer her away from talking about this stuff after she had said her token happy birthday.

[–]SmartLlama 127 points128 points  (27 children)

Growing up and realising a lot of the adults you remember from childhood aren't as awesome as you thought sucks.

Big time. I’m experiencing the same with some relatives right now. I’m sorry you’re having to deal with that

[–][deleted] 53 points54 points  (21 children)

My oldest brother is 14 years older than me. I wanted to be just like him until I was a teenager and realised he's just a terrible person. Also believes the earth is flat.

[–]DrinksOnMeEveryNight 12 points13 points  (0 children)

Yep, realizing my grandmother who I looked up to is actually a racist Trumper really subverted my opinion of her.

I was too young/uneducated to realize how hateful her comments were about Black people, Asian people, even Polish people. She loves animals but votes for GOP candidates who say “drill, baby, drill!” heck no.

[–]vidul7498 79 points80 points  (10 children)

The virus had brought out the worst in people, I never knew so many people would object to wearing a cloth on their face if it has the slightest of chance of saving a life

[–][deleted] 11 points12 points  (0 children)

Apparently, wearing a mask is too much of a sacrifice for some people. Shows you exactly how much consideration, care and empathy they have for others... and how much of the same they deserve.

[–]Sinity 2 points3 points  (0 children)

I never knew so many people would object to wearing a cloth on their face if it has the slightest of chance of saving a life

It's mostly throwing an emotional tantrum. They're in reality pissed about other measures like lockdowns... so when there's no lockdown they lash out like this, contributing to another lockdown potentially...

And hypocrisy of politicians might be a factor. For example "leader" of my country (Poland, he's, uh, 'unofficial' leader - officially he's deputy PM now, before he was, as he called it, 'just an ordinary MP') seems to make a point about disregarding wearing a mask.

On 10.11 when people were forbidden from visiting graves - he drove to visit his family graves in a limo, with some other people (politicians and his private security, I guess), disregarding social distancing. No one else in Poland could (well, legally). Photo, he's a midget second from the right.

[–]Hendlton 17 points18 points  (3 children)

Yup... Finding out a lot of people you know are complete selfish dumb asses, wannabe rebels, but not when it actually matters, only when it's convenient. I almost wish this virus was worse, so it could scare some sense into them when it comes ravaging through our town. Instead they're leaving it all up to "God's will" and getting annoyed every time the government announces new measures.

[–]Cndymountain 5 points6 points  (0 children)

I have 3 aunts of which 2 hold PHD’s in medicine related research. Then there’s the anti-vaxxer...

I feel you mate. The anti-vax one was my favourite to visit as a child :(

[–][deleted] 25 points26 points  (7 children)

This is manna from heaven for the conspiracy loons. They're making a meal out of bugger all.

[–]beerdude26 18 points19 points  (6 children)

I know, right? It's like 33 people out of 3 million. I can find 33 people in 3 million that have explosive diarrhea a few days after the vaccine. Doesn't mean that shit is causation

[–]Electricfox5 10 points11 points  (1 child)

Happy Birthday though!

March 14th birthdays are the best. :D

[–]Danulas 4 points5 points  (0 children)

Amen! It's a tradition for me to get pizza on my birthday because Pi Day.

[–]Bi-bara-boop 2 points3 points  (0 children)

Turns out that my parents are anti-vaxxers as well... my brothers and me were lucky enough that they were immigrants who didn't understand the language well enough and they trusted the doctors to take care of us...

The discussions I had with them because I'm getting this (and other) vaccines is just mind-boggling.

[–][deleted] 7 points8 points  (0 children)

My godmother is exactly the same, but she has still got hers only because she works as a hospital administrator and her mother has cancer. She said she did it only because she was forced, and would have never got it if it were up to her. She questioned me 300 times when I got mine and now she's questioning me again, but got Pfizer not AZ.

[–][deleted] 8 points9 points  (12 children)

It's more than that I think. A LOT of older people, even ones who are usually wise are starting to wanna reject the vaccine. When this many people are becoming skeptical, I think it's a sign you should be looks at why it's happening. You can claim "they're all idiots" as much as you want, and probably be right, but there must be a legitimate reason so many normal people are getting turned off it, and frankly I blame failure in leadership.

[–][deleted] 30 points31 points  (4 children)

""It has not been concluded that there is any link between the Covid-19 vaccine AstraZeneca and these cases,” Dr Glynn said. However, acting on the precautionary principal, and pending receipt of further information, the NIAC has recommended the temporary deferral of the Covid-19 vaccine AstraZeneca vaccination programme in Ireland.”

[–]Brickleberried 33 points34 points  (2 children)

Pausing the vaccine has a 100% chance of killing more people than the potential for blood clots that currently has no link to the vaccine.

This is why the Precautionary Principle is not the end-all-be-all for ethical action.

[–]engi_nerd 8 points9 points  (0 children)

Actually no. Ireland is using mostly Pfizer, so this (likely) temporary pause won’t affect how many people get vaccinated.

[–][deleted] 2 points3 points  (0 children)

Pausing the vaccine has a 100% chance of killing more people than the potential for blood clots that currently has no link to the vaccine.

Why does no one seem to get that this isnt the problem, its the trust people have in the vaccine thats at stake here.

Sure it might be that the pandemic kills more than the vaccine, but if you have chance to DIE due to the vaccine, there are a lot of people, myself included, that wont take it.

I have been super careful so far and can stay this way for longer, my risk of infection is basically ignorable, but if i take the vaccine i definitely have a risk of suffering blood clots that can harm my body irreperably or even kill me and i wont take that chance, no matter how small.

Especially considering that it has been shown that these rather rare blood clots in the brain are really uncommon for people below 50 and also for men vs. women, and the people that died to it in germany were all between 20-30 men and women.

[–]green_flash 701 points702 points  (323 children)

They say it's out of an abundance of caution, but it borders anti-science fear mongering.

More than 17 million doses of the AstraZeneca vaccine have been administered by now and there is absolutely no evidence of an increased risk of blood clots among recipients of the vaccine.

I really hope it doesn't lead to more people refusing the vaccine.

[–]M2704 63 points64 points  (12 children)

I’d wager to say that not investigating concerns and taking this seriously would make way more people wary of taking this vaccin.

[–]mogulman31a 23 points24 points  (0 children)

These people are responsible for ensureing the safety of drugs. They relaxed the approval process for obvious reasons. However, since so many people will be getting this vaccine in such a short time frame any possible indications of serious side effects need to be considered. Here's one way to look at it, for the sake of argument let's say the AZ vaccine does increase clots and hemorrhage in younger people who receive. One year from now a lot of people in Ireland are dead or suffering effects of the clot. Do you think people will say, well the drug safety people had no choice, or do you think they'll want their heads on a pike? The thing is were are over a year into this pandemic but on track for unprecedented vaccination rates, I think it's fair to slightly slow the role out if need be.

[–]ViolentlyCaucasian 69 points70 points  (8 children)

Broadly agreed though the talk I've seen suggests the concerns are around potential quality control issues or bad batch supplied to EU. If multiple countries have reported issues, it would be worth assessing if the administered doses related to the clotting issues came from the same batch or production facility rather than continuing to charge ahead. AZ have hardly covered themselves in glory throughout this whole process with poorly structured trials, production problems and for the EU massive delivery shortfalls. It's not unreasonable that governments would be cautious even if the efficacy of the vaccine itself is not in doubt

[–]green_flash 40 points41 points  (0 children)

bad batch

As far as I know the concerns were about different batches. Austria had concerns about ABV 5300 after three cases of thrombosis, but an investigation found no peculiarities in it. Other countries also reported no issues at all with this batch. France for example inoculated around 150,000 people with doses from this batch and they say "there have not been any reports of deaths, life-threatening side-effects, or any cases of thrombosis or blood thickening". In Denmark, there was apparently also a case of thrombosis with the ABV 5300 batch, but Denmark only reacted after Austria's precautionary measures.

Italy had concerns about ABV 2856.

[–]FarawayFairways 39 points40 points  (4 children)

Broadly agreed though the talk I've seen suggests the concerns are around potential quality control issues

Something is beginning to look a bit odd, and the data from the UK, where they've administered about 11m doses now tends to point the finger at this being a European issue, which in turn leads to a QC explanation

The UK has published all their data and the sample population of people receiving injections (the blood disorder reports appear on page 2)

You can see the of data here which was published 5/6 days ago which shows all the side effects from the AstraZenaca vaccine in the UK.

https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/968414/COVID-19_AstraZeneca_Vaccine_Analysis_Print.pdf

Same data available for Pfizer/Biontech is available as well. So far at least the Pfizer vaccine has generated more 'yellow card' reports than AstraZeneca related to blood issues, albeit this is largely due to Lymphadenitis. Both vaccines have one close proximity death related to Thrombocytopenia

https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/968413/COVID-19_mRNA_Pfizer-_BioNTech_Vaccine_Analysis_Print__2_.pdf

Other information can be found at the following pages. https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine-adverse-reactions/coronavirus-vaccine-summary-of-yellow-card-reporting

https://coronavirus.data.gov.uk/

It's tempting to wonder if the European's pressurising AstraZeneca to deliver has led to some short cuts in production?

The UK has used both vaccines in broadly equal measure. AstraZeneca has 275 yellow card reports and Pfizer 227

This should get updated early next week

One thing that might be relevant of course is that Europe has been vaccinating younger people with AstraZeneca than the UK has, and there seems to be a disproportionate number of bad reaction reports coming from the under 50's

Very rare reactions can of course escape stage 3 trials. Science knows that. They only tend to reveal themselves at scale. Europe would have been better had their regulators followed the UK and effectively used the UK to break the trail for them. Instead they refused to sanction the use on older people because of lack of data (despite the UK generating more in a morning than the stage 3 trials generated in their entirety). Europe's younger cohorts then became real time guinea pigs

[–]green_flash 15 points16 points  (3 children)

We're talking about 3 cases in Austria, 1 case in Denmark and 4 cases in Norway, with one of each fatal as far as I know. In addition, there are reports about 3 deaths in Sicily.

France alone has administered half a million AstraZeneca vaccine doses and has registered one case of thrombosis so far. This is little more than hysteria and populist politicians pandering to vaccine-skeptical voters.

[–]AnFearFada 16 points17 points  (2 children)

Except that in the case of Ireland it is an independent advisory board of specialists that have paused the use of AZ.

They said it was because of cases of brain hemorrhage in younger adults and that they don't expect there to be causal link between the events and the vaccine, they are only pausing it for a few days to fully review the data available.

That seems completely reasonable to me.

[–]4feicsake 46 points47 points  (30 children)

an abundance of caution

It's important to press pause and investigate these claims. If they are unfounded, they'll start using it again but if they find an issue, they will have protected patients from potential health affects.

Continued trust in our regulatory authorites is the most important thing right now. Not taking claims seriously now would create distrust and lead to more people refusing the vaccine than taking a time out and ensure it's all good.

[–]Jarriagag 45 points46 points  (20 children)

A friend (21, female) got the AstraZeneca vaccine in Spain and apparently she got a clot in her arm. She is not anywhere in the news because she is fine now, but I imagine that like her there are many other people, and the cases are pilling up.I am pro vaccines and I still believe that the benefits exceed the risks of getting it, but these things need to be researched. I know the chances of getting bad side effects are very low, but I can't but to feel a bit scared that I would be that one person in 100.000, or whatever the number is.

[–]green_flash 69 points70 points  (16 children)

these things need to be researched.

They are being researched. Every case of adverse reactions has to be reported back to the EMA. The EMA says:

The information available so far indicates that the number of thromboembolic events in vaccinated people is no higher than that seen in the general population. As of 9 March 2021, 22 cases of thromboembolic events had been reported among the 3 million people vaccinated with COVID-19 Vaccine AstraZeneca in the European Economic Area.

Source: EMA press release from 4 days ago

[–]istareatpeople 3 points4 points  (1 child)

What's the way a person with a blood cloth like in op's example gets registered in ema's statistics?

[–]green_flash 1 point2 points  (0 children)

In medical terms, a blood clot is a thromboembolic event.

There are two main groups:

OP's example would be DVT

[–]MechaTrogdor 16 points17 points  (9 children)

There is evidence, that’s why like 10 countries have paused to investigate...

[–]Steveskittles 28 points29 points  (14 children)

As an Irish person I'm so pissed off with this decision. The UK is a perfect data set to prove this claim is false and that correlation doesn't equal causation. Our roll out of vaccines on a whole is a joke and extremely slow and the AZ vaccine could really help with a more widespread rollout. Absolutely fuming at this news

[–]redox6 27 points28 points  (8 children)

The worry is about a problem with a certain batch, the UK data set alone does not help there. Though I also think that the benefits outweigh the risks. There will surely be more deaths due to this deciion.

[–]green_flash 23 points24 points  (2 children)

The France data set helps with this particular batch:

https://www.connexionfrance.com/French-news/France-issues-statement-on-AstraZeneca-and-batch-ABV5300

Also why suspend all vaccinations if the concerns are only about a specific batch?

[–][deleted] 35 points36 points  (34 children)

Except there is evidence. These countries are not stupid, they wouldn't just pause it without evidence. Whether that evidence is true or not, we have yet to see.

[–]raymengl 70 points71 points  (3 children)

I'm probably way off the mark here, but doesn't Covid-19 give an increased risk of blood clots? I'm sure the NYT had a full article about it a while back.

And if that's the case, then wouldn't there be similar risks from the vaccine designed from the original virus?

[–]fuckyouyoufuckinfuk 29 points30 points  (3 children)

I wish there was this amount of concern about blood clots with birth control pills.

[–]Warm-Maintenance-670 8 points9 points  (1 child)

There is. These days it's highly recommended you get tested for Factor V Leiden before taking it.

[–][deleted] 11 points12 points  (0 children)

Not sure where you live but that is not standard of care in the US.

https://www.nature.com/articles/gim200128

[–]hungoverseal 47 points48 points  (7 children)

COVID-19 is heavily associated with blood clots. The UK has seen zero evidence of blood clots relating to vaccination despite millions upon millions of vaccinations and high-quality monitoring. The most blinding obvious answer is that these people probably caught SARS-COV-2 shortly before being vaccinated and are suffering side effects from the virus rather than the vaccine.

[–]LaVulpo 27 points28 points  (5 children)

Or maybe there’s something wrong with production, they don’t know. That’s exactly why they are investigating.

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[–]Ellie_Spares_Abby 4 points5 points  (4 children)

I got vaccinated four days ago and I haven't talked to anybody IRL about this because it's embarrassing but I've just had this raging boner ever since. It goes away, it isn't like a priapasm or anything, but it literally just shoots up into a stone tower at the slightest breeze. It's worst than being 15 again.

Has anyone else had problems with their junk being overactive? Don't get me wrong, this is preferable to ED but I don't want to be the guy who gets boners all the time when I go back to the office eventually...

[–][deleted] 78 points79 points  (10 children)

This is absolute garbage. There were just as many incidences of this (which were extremely rare anyway) with the Pfizer. There's an abundance of caution, and then there's letting people catch the virus and die of if who would otherwise have been vaccinated. This doesn't make sense at all - this looks like a repeat of the same groupthink we saw last March.

This vaccine has had so much bad press, it's hard not to speculate that someone, somewhere, doesn't like the fact it's cheap and not being sold at profit. It's as though with some countries there's no sense of urgency in vaccinating people and lifting these damaging restrictions.

[–]Justinian2 42 points43 points  (8 children)

The National Immunisation Advisory Committee which made this decision is a group of leading research scientists, I wouldn't call their cautionary pause "fearmongering" they just have to pause it until they have more data.

[–]SecondAccount404 43 points44 points  (4 children)

This decision seems completely irrational given the number of thromboembolic events isn't higher than what you would expect from any random section of the population.

Presumably there must be tonnes of other conditions that are also showing up in vaccinated people by pure chance, why have thromboembolic events been singled out here? And why halt vaccinations if there is no data linking the two? Investigate yes, thats how good science works, but why take action against the current data? This decision wasn't about science no matter how much they claim so.

[–]Joliet_Jake_Blues 9 points10 points  (4 children)

Anti-vaxxers are like, "see? See? This is why I didn't get Braylynn their vaccines!!"

[–]whorin_bajoran 14 points15 points  (0 children)

I have an auto immune disease and I got the vaccine done yesterday. The gp administering it said I won’t have antibodies for 2 weeks, so I do wonder how much of these supposed cases of clots, have involved people who already have caught covid or caught covid just after? Covid is known to cause blood clots and there is no evidence the vaccine does. Oxford and Astra Zeneca have done an incredible job.

If any one gets the vaccine my only advice is to take it easy for a day and have painkillers on hand as it does hit you with flu symptoms.

[–]SwagChemist 2 points3 points  (0 children)

If the Biontech and AstraZen vaccines both have reported blood clots but one vaccine is proven more effective than the other, then guess which variant of vaccine people will fight over...

[–]GoTuckYourduck 2 points3 points  (0 children)

I would be afraid, but I wouldn't be surprised if I've already been an asymptomatic victim of COVID-19, and the long-term consequences are worse. The stats are much better on the dumbed down virus AstroZeneca uses, and from my understand the immunization is better to boot. It's much better than getting it through the sheer probability of your getting it. If you haven't gotten COVID-19, well, it only takes one case to get it circulating and there are new variants going around for which simply getting sick once (which will consume and weaken your immune system even more in the process) won't be enough to protect against.

[–]K_man_k 29 points30 points  (8 children)

This is not an anti-vax move at all, this move is based off what Denmark and Norway are doing and saying. In the long term investigating these risks will boost confidence in the vaccination programme.

[–]Particular-Ad-2376 14 points15 points  (2 children)

Can I just add that this is just precautionary; a government based decision on foot of a recommendation from the National Immunisation Advisory Committee. It’s not some anti-Brit slander campaign. I’m Irish. We want the country to get vaccinated as fast as possible so this blip is very frustrating but nothing to do with Brexit. I believe our Taoiseach even spoke to Boris Johnson about possibly procuring vaccines; naturally Johnson wants to get his own country sorted first, which is completely understandable but there was an expectation to ask and so he did. Most people I know are and would be happy to take Astra Zeneca. Could the conspiracy theorists please give it a rest. The anti-EU rhetoric is getting old as is the anti-Brit talk. Can’t we all just get along at this horrible time?

[–]Professional-Day9939 17 points18 points  (1 child)

The four cases in Norway were all Nurses. Similar findings from Korea, Denmark and Austria. Nurses in France and Germany refused the AZ a number of weeks back.

One theory emerging is that if you have previously had COVID-19 which increases the likelihood of blood clots, the AZ vaccine further exacerbates it.

Benefits still outweigh risks

[–]green_flash 6 points7 points  (0 children)

Nurses in France and Germany refused the AZ a number of weeks back.

Only some of them refused. 38 percent of nurses reject a vaccination with AstraZeneca according to a poll.

[–]GrimmRadiance 5 points6 points  (0 children)

This is why I said I’m in no rush when people asked me if I wanted to be first in line for a vaccine. I’m young and healthy, and I isolate almost completely. Plus the three things I don’t want to be first to try are restaurants, rollercoasters, and medicine.

[–][deleted] 38 points39 points  (20 children)

it's good that they are taking precautions and being careful

[–]oniony 41 points42 points  (18 children)

Is it though, if the alternative is significantly more people dying of covid-19? Covid-19 is a proven risk. The evidence suggests AZ vaccine prevents most deaths. If there is no alternative vaccine available then it would be irresponsible to stop administering it. If they have other vaccines in stock only then they could afford to take the AZ one off the table.

[–]fucktifiknow 18 points19 points  (2 children)

Ireland have 2 other vaccines in use Pfizer and Moderna. It was decided by the NIAC that AZ would not be given to over 70s this cohort attributing to the majority of deaths here.I don't really agree that pausing its use temporarily is going to lead to more deaths.