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BiotechnologyModerna’s mRNA cancer vaccine works even better than thought (freethink.com)

submitted by rchaudhary

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[–]Sevenfeet 3520 points3521 points  (351 children)

I have some experience working on the Covid vaccine from the clinical data side. I've been telling everyone since 2020 that the real silver lining of going through the pandemic is that we now have an inkling of what mRNA therapies can achieve. After all, cancer was what was being researched for mRNA before the pandemic. And yes, specialized individual "chemo" is going to cost a fortune at first.....$200K+ per patient. But eventually the cost will get at or below what conventional chemo treatments are and then the game will really be changed. And there is another study that recently made the press that had similar efficacy numbers for pancreatic cancer.

[–]Evergreen_76 1648 points1649 points  (230 children)

200K+ Is nothing compared to years of standard chemo.

[–]pacmanwa 857 points858 points  (185 children)

My wife had to have six rounds of high grade chemo at 20k/each. Then eight rounds of low grade at 16k each. We only know how much it costs because it was covered under insurance, and we got an "explanation of benefits" for each treatment. Her first round of chemo burnt through our entire deductible. So... it would have been almost 50k cheaper, and that doesn't count the surgeries and radiation after.

[–]Gimme_The_Loot 428 points429 points  (55 children)

How you and the wife doing these days? Hopefully a full recovery?

[–]pacmanwa 662 points663 points  (34 children)

Chemo and radiation ended just over six years ago. Doctor declared full cure, and we had another child. Still have to do a quarterly blood draw for monitoring.

[–]PmMeGPTContent 341 points342 points  (1 child)

I wish you, your wife, and your children many long and happy years <3

[–]BuxtonB 113 points114 points  (0 children)

You, you're a delightful person.

Keep doing what you do.

[–]Xasf 64 points65 points  (4 children)

I lost both my parents to various types of cancers after burning through 1M+ for chemo/radio/isotope etc. treatments over 10 years, so better stories like this really do bring a smile to my face.

My very best wishes to your wife and your whole family!

[–]staminaplusone 70 points71 points  (0 children)

Fantastic news.

[–]F-around-Find-out 6 points7 points  (0 children)

Congratulations.

Fuck cancer!

[–]Content-Test-3809 16 points17 points  (0 children)

Fuck yeah! Excuse my excitement, but I’m just really glad to hear that.

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    [–]Capital_Pea 87 points88 points  (98 children)

    What happens if you don’t have insurance? Do people in the US die of cancer because they can’t to pay for it? Or is there something that covers it? I’m Canadian and can’t fathom this.

    [–]Aureliamnissan 46 points47 points  (4 children)

    There is medicaid, but you have to apply for it and might not qualify if you have any significant income due to means testing. You also might get denied the first time around just because they need to know if you’re serious (unemployment is often categorically denied initially). The second application is actually reviewed and much more likely to get approved. Hopefully the caveat hasn’t progressed by then.

    Also a lot of places don’t accept Medicaid

    [–]lm-hmk 34 points35 points  (0 children)

    In the US states who took federal money for the Medicaid expansion, Medicaid is so very easy to qualify for and obtain. It’s based on income, not assets.

    Many places take Medicaid, actually… because the gov has private insurers take those cases. So you’re not really using your straight up Medicaid at your doctor. More likely it’s a specific plan offered by, for example, United Healthcare.

    Disability, on the other hand… that one is always denied first time around, and people typically make use of an attorney to navigate the system. The whole system and process is entirely fucked. It’s completely awful.

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      [–]FuckinBastard1331 75 points76 points  (11 children)

      Lady I used to work with 15 years ago, her husband was diagnosed with cancer, his cheap insurance wouldn’t cover the treatments and he literally had to die so they weren’t homeless and his wife in inescapable debt.

      [–]Re5p3ct 49 points50 points  (1 child)

      The American dream!

      [–]Snuffy1717 11 points12 points  (0 children)

      Literally talking to an American on voice chat in a game the other day who couldn’t understand why I felt bad for him… He was super pleased about being taxed lower than I was (as a Canadian, and it wasn’t that much less tbh) but talked about how the doctor wants $89,000 to fix his broken foot…

      [–]DuntadaMan 53 points54 points  (7 children)

      If you find you have cancer by the way, contact a lawyer immediately to figure out how to split up your property while you are still alive so it can't be taken out of your estate.

      Everyone keeps talking about how "wealth gets spent within 3 generations." Yeah that's because Grandpa gets old, and the state takes all his shit to pay his medical bills leaving the rest of the family with nothing and debt collectors trying to convince the family they somehow owe money.

      [–]Necessary-Reading605 16 points17 points  (5 children)

      Debt collectors are legally endorsed thugs

      [–]Beat_the_Deadites 4 points5 points  (0 children)

      You're not entirely wrong, but the (current US) alternative is payments up front for medical care and rejection if you can't pay.

      Theoretically the money goes to the doctors, nurses, staff, infrastructure, equipment, pharma, etc. that work their asses off to try to keep the human machine running beyond its warranty period. They've earned that money and should be paid. The execs/business people siphoning off their oversized share, on the other hand...

      The battle to keep people alive will inevitably be lost at some point, though, and there's no simple mechanism to decide when to admit it's lost and stop throwing money at the problem.

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            [–]robotkermit 37 points38 points  (4 children)

            Do people in the US die of cancer because they can’t to pay for it?

            yes, of course.

            This latest study, published Monday in Journal of Clinical Oncology, showed that cancer patients who go bankrupt are nearly 80 percent more likely to die than patients who don't, and some cancers had significantly higher mortality rates.

            https://www.fredhutch.org/en/news/center-news/2016/01/cancer-bankruptcy-death-study-financial-toxicity.html#:~:text=This%20latest%20study%2C%20published%20Monday,had%20significantly%20higher%20mortality%20rates.

            [–]CherryShort2563 9 points10 points  (0 children)

            What a nightmare. So on some level healthcare system is as much of a killer as cancer is.

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              [–]oeCake 95 points96 points  (18 children)

              Their rugged individualism allows them to weather and support themselves in those trying times

              [–]thelocker517 45 points46 points  (7 children)

              Or the ever popular GoFundMe page.

              [–]Zebidee 76 points77 points  (4 children)

              Imagine a permanent GoFundMe that everyone paid into that paid out for medical bills regardless of if you're pretty/popular/pathetic...

              [–]vaanhvaelr 15 points16 points  (1 child)

              Socialised medicine with extra steps.

              [–]BBQBakedBeings 47 points48 points  (6 children)

              We eliminate the tumors from our bodies by our boot straps

              [–]eleanor61 12 points13 points  (2 children)

              I hate that I laughed at this.

              [–]a_shootin_star 5 points6 points  (1 child)

              Don't. Humor puts the absurd into perspective.

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                  [–]wren337 33 points34 points  (2 children)

                  The medical system in the US has killed or bankrupted millions, including people who have low-quality insurance with benefit caps that you burn through very quickly in these situations.

                  Edit: 500k bankrupted and 45k premature deaths annually due to our globally unique for-profit health system.

                  [–]whatadai 36 points37 points  (17 children)

                  First choice is you don't pay and you die. Second choice is you go into hundreds of thousands of dollars in debt if you don't have insurance and don't die. Third choice is you go into that debt and still die and they go after your estate. Fourth choice is you can have amazing health insurance that you pay thousands for annually on top of your employer paying thousands for annually, and you still have an annual maximum out of pocket that's in the thousands that you have to hit before insurance starts paying for everything for the rest of that year. So that maximum out of pocket resets the next year and there's a great chance the maximum is now higher and the premium for that insurance costs more for both you and your employer. How do I move to Canada?

                  [–]reverber 18 points19 points  (1 child)

                  You forgot the part about getting fired after the first year (for other reasons, of course) because the company doesn’t want higher premiums. But hey, at least you have the right to work.

                  [–]whatadai 6 points7 points  (0 children)

                  Thankfully, my wife and I have awesome employers that don't do that and work with our schedules cause seriously, who the fuck wants cancer over working? But I've heard plenty of stories like that, even in California.

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                    [–]WhatWhatWhit 28 points29 points  (6 children)

                    People that have assets usually liquidate them to pay for care. Those of us who don't have insurance and don't have a well to tap are "stabilized" and left to our own devices. Pretty great system we have. /s

                    [–]Abject_Film_4414 14 points15 points  (0 children)

                    They get to survive on thoughts and prayers.

                    Same thing that protects them from school shootings.

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                      [–]ShadeXeRO 8 points9 points  (2 children)

                      Thank you for posting this. I start my 4 cycles of chemo next week. I'm also about to hit the out of pocket maximum from the initial labs & biopsies.

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                        [–]lookmeat 110 points111 points  (16 children)

                        Just to put this in perspective: this is on top of standard chemo. That is the trials they tried and still had surgery to remove as much cancer physically, followed by standard rounds of chemo. Only then are they given the vaccine, which reduces the chance of recurrence and increases the chance of remission.

                        That said I'm the future, with more data chemo strategies may be reconsidered given that the vaccine is around. This is huge, and considering that half the people who go through chemo and still die will now live with this, it's amazing news. But we're just starting.

                        [–]Kroutoner 68 points69 points  (4 children)

                        Chemo is standard of care and any study is going to likely be performing a comparison of supplementing standard of care. The study wouldn’t make it past an IRB if it didn’t.

                        As you say though, future studies may reconsider.

                        [–]lookmeat 14 points15 points  (1 child)

                        Yup, just wanted to explain that it's $200k on top of everything else you already go through. But as it gets cheaper and better understood we'll start seeing differences.

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                          [–]Dragon_Fisting 20 points21 points  (8 children)

                          Huge ethical problem with not giving them standard chemo. This could very well be effective even without or with less chemo, but it'll need a lot more research before it's even close to ethical to test that out.

                          [–]Langsamkoenig 3 points4 points  (1 child)

                          Will be easier for cancers that are a 100% deadly like late stage pancreatic. As a patient I'd opt out of chemo (no point in being poisoned in my last days on this earth) and roll the dice with the vaccine and an ethics comission would likely agree that there is no point in adding chemo.

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                              [–]The-Fox-Says 24 points25 points  (0 children)

                              I think this vaccine is supposed to be a supplement to mainstream cancer therapies

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                                [–]mtcwby 100 points101 points  (24 children)

                                Pancreatic Cancer seems to run in my family having killed my grandfather and three aunts. My understanding is it's not particularly easy to detect until too late either.

                                [–]ThatHorseWithTeeth 57 points58 points  (11 children)

                                One of my friends just started chemo last week for pancreatic cancer (stage 1). They caught it early - fingers crossed. No idea what the prognosis is at this point. Cancer sucks.

                                [–]mtcwby 40 points41 points  (1 child)

                                I'm glad they caught it early. Cancer sucks anyway but Pancreatic caught later has a high fatality rate.

                                [–]Grablicht 25 points26 points  (0 children)

                                Very high rate, after 5 years over 95% are dead

                                [–]OMEGA__AS_FUCK 29 points30 points  (3 children)

                                My dad was diagnosed stage 1. He did chemo and had a Whipple. He’s still here and heavy three years later. I’m hoping the outcome is good for your friend as well.

                                [–]Natty-Bones 5 points6 points  (2 children)

                                They caught my father's pancreatic cancer early, in 1999. He had a full Whipple and chemo, and participated early gene therapy trials at NIH and DOD. He lived another six years, and likely would still be alive if he had managed to quit smoking and drinking. I wish your father the best of luck. A good attitude will get him very far, and today's medicine is practically a miracle.

                                [–]TryUsingScience 13 points14 points  (0 children)

                                Pancreatic cancer is among the most curable of all cancers if you catch it early and among the least if you catch it late. There's a very good chance your friend will be fine.

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                                  [–]sammybeta 24 points25 points  (4 children)

                                  I've read an article about the difficulty of diagnosing pancreatic cancer. One difficulty is to determine early cases through MRI or ultrasound images, as it requires highly experienced doctors to diagnose. I think it's an area where AI is going to shine.

                                  [–]mtcwby 2 points3 points  (2 children)

                                  /redpick in a response had some good links on experiments being done. The selfie of your eyes app seems like a good idea and I'm going to reach out and see what's involved in trying it. Certainly have the family history and I'm old enough.

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                                    [–]appelflappe 8 points9 points  (0 children)

                                    Unfortunately true. A friend of mine got diagnosed with pancreas cancer a few weeks ago. They gave him untill february max. He just. Turned 29 and had very little symptoms even when he got diagnozed.fuck cancer

                                    [–]Maguire4BallonDOr 6 points7 points  (2 children)

                                    Are there such things as regular screenings for this type of cancer?

                                    [–]mtcwby 10 points11 points  (1 child)

                                    Not that I'm aware of. The saving grace for my family is it typically happens much later in life.

                                    [–]redpick 29 points30 points  (0 children)

                                    If you have a family history like that, you should seriously consider some of the following options:

                                    - Clinical trials for screening https://clinicaltrials.gov/search?locStr=United%20States&country=United%20States&distance=50&cond=Pancreatic%20Cancer&term=Screening&aggFilters=status:not%20rec the very first one is for people with family history of pancreatic cancer but you need to be age 50+

                                    - Multi-cancer early detection tests like https://grail.com/galleri-test/

                                    - You could also have other tests done like an ultrasound or eye test (like this, not sure where to get a test based on it, but pancreatic cancer should be detectible early in the eyes) https://www.washington.edu/news/2017/08/28/new-app-uses-smartphone-selfies-to-screen-for-pancreatic-cancer/)

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                                      [–]jo_mo_yo 60 points61 points  (3 children)

                                      Despite the pain of pharma pricing, looks like it'll be a healthy margin product. That'll make widespread investment more enticing and speed up mass production. It makes you think about what the final market price we would accept per person would be for a guaranteed, widespread preventative solution. And, for example, if we did get to prolong life in old age with less cancers, would the extra financial burden on the healthcare systems to take care of older, sicker, non-working people be worth the expense of vaccination - either way, Pharma is winning at both ends of that scenario with both vaccines and late in life care...

                                      [–]InSearchOfLostMagic 23 points24 points  (11 children)

                                      I knew a woman in her 30s who died from cervical cancer not so many years ago. I believe that type can be treated now?!

                                      [–]No-Factor-8166 57 points58 points  (5 children)

                                      90% of the strains of HPV that cause cervical cancer are preventable with the HPV vaccine. Women AND men should get the vaccine as early as the age window allows!!

                                      [–]elderlybrain 23 points24 points  (1 child)

                                      99.8% to be precise.

                                      The 0.2 is probably still down to hpv but we just weren't able to prove it. The hpv vaccination programme should have been rolled out to everyone for free at any age and it would probably have reduced cervical cancer rates faster.

                                      For statistics in India, cervical cancer is the 2nd leading cause of cancer deaths in women. In the UK, it's the 19th.

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                                        [–]Telvin3d 30 points31 points  (3 children)

                                        Partially treated but almost completely prevented. HPV causes the vast majority of cervical cancers. Everyone, female and male, should have the HPV vaccine

                                        If we were serious about it we could eliminate that cancer the way we eliminated polio

                                        [–]DuntadaMan 10 points11 points  (0 children)

                                        But by preventing death from cancer we are practically telling teenagers to have sex! - Way too fucking high a percentage of the population.

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                                              [–]omnichronos 1525 points1526 points  (99 children)

                                              So it's specific to skin cancer or melanoma. I look forward to vaccines for other cancers.

                                              [–]EntrepreneurBehavior 622 points623 points  (48 children)

                                              One for pancreatic cancer would be great

                                              [–]crabby135 370 points371 points  (25 children)

                                              Other institutions are having great results with their trials of mRNA pancreatic cancer vaccines.

                                              [–]Ordinary-Ask-3490 234 points235 points  (24 children)

                                              After a Phase I trial, 50% of patients (in a sample size of 16) had recurrence-free survival. Very great news!

                                              I personally think the reason why the survival rate wasn’t higher is because pancreatic cancer affects mostly elderly people, so trying to illicit an immune response would be increasingly difficult. Same goes for other mRNA cancer vaccine trials, a trial for melanoma was around the 50% survival rate, too.

                                              [–]Joliet_Jake_Blues 35 points36 points  (9 children)

                                              My dad was early 60s

                                              [–]suremoneydidntsuitus 31 points32 points  (8 children)

                                              Same. 3 weeks between diagnosis and the funeral :/

                                              [–]fluteofski- 55 points56 points  (5 children)

                                              Same. We had 3 weeks. At diagnosis, they said 9 months. Couple appointments and 5 days later. They said 3 months. Another week. Seeing specialists getting ready for treatment they said a month tops. He got a chemo tube installed, and at the surgery they told us 3 to 5 days tops. We were lucky they did the surgery tho, becuase they installed one of those tubes in his stomach area to drain the fluids from around his stomach, which we were able to do at home.

                                              My father had nothing setup. I dropped everything went from knowing nothing about wills, trusts, and subsequent tax laws, to an expert in the matter of two weeks (when I started I didn’t realize that’s all I had). My sister would set up all the doctor appointments and figuring out which specialist to see. During the day I was driving him to all his dr appointments. At night I was reading. I managed to create and get all of his assets, bank accounts, properties, etc, correctly into a trust in those 2 weeks. It was such a blur. His final account and property deed arrived on a Friday, he looked, nodded and passed on a Saturday.

                                              As stressful as it was doing all that it was nice being in the car with him between all the appointments just hanging out. Miss the guy.

                                              [–]Neat-Statistician720 16 points17 points  (2 children)

                                              Ngl it could be that he wanted everything to be squared away before he passed and held on for it. I’ve heard a lot of stories about dying people holding out for that one last thing they want then giving in and finally letting go.

                                              My grandpa had pancreatic cancer too and died quite fast, roughly 2 months. My family is out of state but he held on until my mom came into town again and after the family’s last thanksgiving together he died a day later. He seemed very determined to see us all once more and I firmly believe the desire to live cba help hold out.

                                              [–]Enough_Shoulder_8938 4 points5 points  (1 child)

                                              6 months for my dad, a couple rounds of radiation gave him a little extra time though it was terrible for him

                                              [–]Ensirius 4 points5 points  (1 child)

                                              Damn that is brutal. Sorry for your loss.

                                              [–]Hyperious3 6 points7 points  (3 children)

                                              I wonder then if you can just keep blasting them with boosters until their immune system gets the idea

                                              [–]T43ner 8 points9 points  (0 children)

                                              This is like slapping on more rockets in KSP

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                                                  [–]SniperPilot 51 points52 points  (5 children)

                                                  One for Breast Cancer would be amazing.

                                                  [–]EntrepreneurBehavior 17 points18 points  (1 child)

                                                  Agreed..one for all cancers would be awesome. Currently in the hospital with pancreatitis due to a SPINK1 mutation that makes me more susceptible to acute attacks.

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                                                    [–]FewDevelopment6712 32 points33 points  (12 children)

                                                    And prostate and testicular cancer

                                                    [–]stick_always_wins 48 points49 points  (10 children)

                                                    Testicular cancer is so easily detectable, treatable, and survivable that R&D for a vaccine is unlikely to be a priority. But pancreatic cancer and prostate cancer are much deadlier

                                                    [–]slog 17 points18 points  (8 children)

                                                    Prostate cancer is way less deadly year over year. I know because I've been tracking it since I'm almost guaranteed to get it, if I don't already have it. Outcomes are barely a worry, and quality of life is getting better all the time post-treatment.

                                                    [–]GraceStrangerThanYou 16 points17 points  (4 children)

                                                    More people die with prostate cancer than from prostate cancer.

                                                    [–]Infamous_Lunchbox 7 points8 points  (3 children)

                                                    True, but you still have to be aware of it. It can spread and kill.

                                                    [–]stick_always_wins 6 points7 points  (0 children)

                                                    Yea it’s pretty impressive regarding the progress we’ve made with prostate cancer but it still has very high prevalence and there’s still some room for more research.

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                                                            [–]Butterflychunks 78 points79 points  (6 children)

                                                            Hey that’s great! I have family members who got melanoma. Just need prostate, uterine, and breast cancer, then my family history is covered lol

                                                            [–]Ordinary-Ask-3490 29 points30 points  (1 child)

                                                            Unsure of an mRNA vaccine for any of those types of cancer at the moment, but I heard some recent news about breast cancer. It was kind of a misleading headline, but researchers believe breast cancer metastases are more aggressive when there are higher levels of the ENPP-1 proteins present. The removal of ENPP-1 proteins hasn’t been done in humans yet, of course, but in mice models there has been success of decreasing metastases / cancer recurrence.

                                                            If we manage to find a way of creating an medicine to suppress ENPP-1 levels and combine it with an immunotherapy like Keytruda, I believe this would greatly reduce the need for invasive surgeries / chemotherapy and radiation.

                                                            [–]Butterflychunks 6 points7 points  (0 children)

                                                            That’s amazing. Hopefully by the time I get cancer, these treatments are ironed out 😅

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                                                              [–]mxpower 68 points69 points  (15 children)

                                                              I imagine this is literally life changing for those who live in places like Australia.

                                                              Very hopeful.

                                                              [–]amfibbius 31 points32 points  (1 child)

                                                              Melanoma is generally where immune-related therapies start, because melanomas have the highest mutation rates vs. other cancers, and that's what the antibodies are engineered to target. Not all cancers are easily targeted by immune therapies if they do not have so many mutations to target that way. However, there is research going on to both apply these strategies to other types of cancers with high mutation rates and to make less mutated types of cancer more easily targeted by immune therapies.

                                                              [–]FblthpLives 23 points24 points  (1 child)

                                                              They are expanding to other cancers:

                                                              The companies are also looking beyond melanoma, launching a phase 3 trial testing the cancer vaccine in people with non-small cell lung cancer.

                                                              [–]taterdanger 22 points23 points  (2 children)

                                                              As someone who has had a melanoma removed: sign me up. Keep this research going for all types.

                                                              [–]lakeghost 10 points11 points  (2 children)

                                                              Moderna is working on an EBV vaccine which is a virus that causes 1% of global cancers. Fingers crossed for even more.

                                                              [–]TheChickening 2 points3 points  (1 child)

                                                              And is also rumored to be a huge factor in developing multiple sclerosis.

                                                              [–]ThisCommentIsGold 8 points9 points  (1 child)

                                                              Skin cancer is literally the most common cancer. Seems like a pretty good fucking start.

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                                                                [–]jon-in-tha-hood 2209 points2210 points  (141 children)

                                                                Fuck cancer.

                                                                So many people I know have either suffered from or died to cancer. I wouldn't wish it on anyone at all.

                                                                [–]3rddog 688 points689 points  (73 children)

                                                                Grandfather in 1972, Uncle in 1986, Mother in 1992, girlfriend in 1994, Father in 2007, Mother-in-Law in 2009, Wife in 2018. Fuck cancer.

                                                                [–]jastubi 269 points270 points  (62 children)

                                                                Holy shit, this can't be normal. Where did all of these people grow up/live? Also, im sorry for your losses.

                                                                [–]MTLBRICK 217 points218 points  (34 children)

                                                                Someone close to our family recently passed away from stomach cancer at 38. His wife passed away from stomach cancer at 30. He then met his second wife at a cancer support group and had a kid. The new wife’s 1st husband died from cancer.

                                                                Imagine losing two husbands to cancer and you met one of them at a support group because his 1st wife died from cancer….

                                                                If I didn’t know the people I’d have never believed it

                                                                [–]NervousBreakdown 102 points103 points  (8 children)

                                                                a friend of mine never smoked a day in his life, wasnt really exposed to much second hand smoke either, less than me thats for sure. Well one day he gets checked out for chest pains or something and they find a tumor the size of of a grapefruit on his lung. He gets it removed, does chemo, all that jazz and a year later it comes back. He doesn't beat it a second time. Then a few years later my other friend (Who was his cousin) tells me the dudes younger brother got the exact same cancer and was dying. fucking horrible for his mother. I had a very very light brush with testicular cancer a decade ago and I should be way more thankful than I am, because I went from finding a lump while scratching my nards to a walk in clinic, ultrasound, diagnosis, surgery and cancer free in the span of a month. I didnt even have to do chemo.

                                                                [–]MTLBRICK 78 points79 points  (7 children)

                                                                Radon is the second leading cause of lung cancer in my country.

                                                                [–]NervousBreakdown 30 points31 points  (5 children)

                                                                I just googled radon and the first result is about Radon exposure in canada. Are we from the same country lol?

                                                                [–]jeff303 35 points36 points  (0 children)

                                                                It's the second leading cause in many places, I suspect. Here in the US, we had the seller put in a radon mitigation system before closing on our house because the basement tested high.

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                                                                    [–]Crystalas 26 points27 points  (1 child)

                                                                    I would, that kind of clustering makes me think something in local environment is tainted and/or a local inherited genetic mutation increases risk.

                                                                    [–]aendaris1975 10 points11 points  (21 children)

                                                                    It really seems like cancer is becoming more and more common than it used to be.

                                                                    [–]MasqueradingMuppet 26 points27 points  (4 children)

                                                                    It seems like it's being caught earlier and earlier though. Also have to factor in that people aren't dying of other causes as often as they did in the past.

                                                                    People living longer plus earlier detection overall (annual mammograms for women over 40, colonoscopies for people over 50, maybe they'll lower to 40 soon) means more cancer but overall, less death from cancer.

                                                                    [–]PurpleHooloovoo 25 points26 points  (0 children)

                                                                    This is extremely important to remember. There are entire classes of cancer that, if diagnosed at a certain age, you just ignore because the cancer will die with you from age or something else before it becomes a problem. We weren't diagnosing those before.

                                                                    It's a bit like the arguments against vaccines and things due to increasing rates of autism diagnosis - in reality, we just have the skills and language and awareness to diagnose people and get them resources to help.

                                                                    Same for "more" queer people today - people have always been queer, but when that would get you killed or ostracized, you kept quiet. "More" just means "more that we know about".

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                                                                      [–]MTLBRICK 21 points22 points  (2 children)

                                                                      My mom is convinced it’s the massive amounts of processed foods and chemicals

                                                                      [–]Cold_Fog 16 points17 points  (0 children)

                                                                      And if this is proven to be true, I wouldn't be one bit surprised.

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                                                                            [–]BurmeseGeneral 35 points36 points  (9 children)

                                                                            One in six people will die of cancer in this world currently unfortunately.

                                                                            [–]c0mptar2000 20 points21 points  (5 children)

                                                                            Yeah, I don't think people realize how common cancer actually is. Plus there's all the people who had cancer and maybe even in remission but ended up dying of something else later.

                                                                            [–]Muscle_Bitch 23 points24 points  (3 children)

                                                                            It's crazy to me that people think cancer is uncommon.

                                                                            I'm only in my 30s but basically everyone I've ever known who has died (like 15-20 people), has died of either:

                                                                            a) Cancer
                                                                            b) Heart attack
                                                                            c) Suicide

                                                                            Like, what else are people dying from, that they think cancer isn't common?

                                                                            [–]PurpleHooloovoo 9 points10 points  (0 children)

                                                                            Well, aside from accidents, things like complications from chronic illness, stroke and aneurysms, heart failure, old age, illnesses....when you get older, the reasons start to add up.

                                                                            Part of that is diagnosing, though. Back in the day, you just died of old age. Now we can diagnose and give a reason for the 93 year old who suddenly declined.

                                                                            Cancer is still extremely common, and the most common I know for people dying relatively young. But there are other things - I only know 2 people total in my life who have died by suicide, and have 5 close family members die from cancer. But I have a friend who has had many many more friends die from the suicide/OD combo pack. We would have different perceptions of what is "common".

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                                                                                  [–]RobertABooey 24 points25 points  (4 children)

                                                                                  Both my parents had colon cancer (dad died, mom survived), and her mother had colon cancer as well.

                                                                                  I went for genetic testing, as at 35 I had pre-cancerous polyps removed during my first early-colonoscopy I had, and it came back we weren't genetically pre-disposed based on the currently known information (they said it could change over time as time goes on and information comes more readily available).

                                                                                  They told us that MOST cancer that humans get (not all, but most), is environmental - exposure to chemicals, radiation (radon is the most common one), poisoned air, shitty food, unhealthy habits like not keeping fit,smoking, doing drugs and drinking alchol.

                                                                                  If you live in North America,look around you next time you're at the mall. 75% of the people you'll find are obese, and think of how many people you know snowplow their alcohol consumption until the weekend, then drown themselves all weekend long. its right there in front of us, we're all just choosing to ignore the reasons why we're all getting sick.

                                                                                  I firmly believe our transition to storing food in plastics in the 60's is what is causing the largest amount of digestive cancers we're seeing. EVERYTHING is stored in plastic. I remember a time when you'd go to the grocery store and you'd pick your fruit from a basket. Now, they come on styrofoam trays with cling wrap around them or they're in plastic containers on the shelf.

                                                                                  We are slowly being poisoned by our environment/lifestyle for various reasons that aren't really on topic here.

                                                                                  [–]branstarktreewizard 17 points18 points  (2 children)

                                                                                  the rise of cancer case recent decade is also due to better detection.

                                                                                  alot of people in the past could have die from cancer and never got it diagnosed

                                                                                  [–]Quant_Liz_Lemon 12 points13 points  (0 children)

                                                                                  A lot of people in the past also died a lot sooner from preventable things. So now people are living long enough to die from cancer, instead of tuberculosis, diphtheria, etc.

                                                                                  [–]cutwordlines 4 points5 points  (0 children)

                                                                                  also longer life expectancy increases cancer as being the thing that kills you (compared to like, being dead in your childhood from the plague say)

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                                                                                      [–]Evilbred 12 points13 points  (0 children)

                                                                                      Brother.

                                                                                      Fuck cancer.

                                                                                      [–]IdontOpenEnvelopes 2 points3 points  (1 child)

                                                                                      Dude my condolences, that's too much loss for any one person.

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                                                                                        [–]popeye44 27 points28 points  (4 children)

                                                                                        Wife was diagnosed with Colorectal in Oct. We're very fucking fortunate that it's stage 2, and very treatable/operable. I truly love that we're kicking it's ass in so many ways, but I cannot wait for the day we can pop a pill or take a shot and wave it off.

                                                                                        Fuck Cancer,

                                                                                        [–]engaffirmative 13 points14 points  (0 children)

                                                                                        Yes fuck it. Hate it.

                                                                                        [–]porizj 8 points9 points  (1 child)

                                                                                        One of the people I care most about in the world, in fact the person to whom I attribute the qualities in myself that people seem to appreciate the most, is as we speak in the hospital battling stage 4 stomach cancer. I have no idea if the hug I gave him as I left to go back to my wife and kids an 8-hour drive away is the last hug I’ll ever be able to give him.

                                                                                        We can’t eliminate this fucking disease fast enough.

                                                                                        [–]ThatBusch 74 points75 points  (29 children)

                                                                                        Yea my grandpa died because of it, although it was sort of his own fault... Smoked for over 20 years.

                                                                                        [–]caleeky 81 points82 points  (1 child)

                                                                                        20 years goes by so fast. Addiction sucks.

                                                                                        [–]ragnarok635 20 points21 points  (1 child)

                                                                                        Fuck addiction.

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                                                                                            [–]HardRNinja 189 points190 points  (10 children)

                                                                                            I was part of a research study for an mRNA treatment for Hodgkin's Lymphoma.

                                                                                            This was after 2 years of traditional treatment and a bone marrow transplant.

                                                                                            All I can say is, anyone who has an mRNA option needs to take it. The treatment was just 30 minutes long a few times a week with absolutely no discernable side effects.

                                                                                            [–]Better-Strike7290 39 points40 points  (1 child)

                                                                                            HOLY SHIT!! That's my cancer. I had traditional treatment at U of M and my oncologist was spearheading an mRNA human trial for Hodgkins. Where did you get yours done at???

                                                                                            [–]HardRNinja 20 points21 points  (0 children)

                                                                                            Mine was done through St. David's hospital as a trial for Nivolumab.

                                                                                            If it's a possibility for you, I highly recommend it.

                                                                                            [–]Grantypants80 33 points34 points  (6 children)

                                                                                            I was diagnosed with NHL in October. Weird journey.. weird location (couldn’t biopsy), and mass removed entirely surgically before they realized what it was. Did some immunotherapy but next scan isn’t until April.

                                                                                            Hoping there will be an mRNA vaccine for NHL soon, instead of playing whack a mole with lymphomas every 5 years or so..

                                                                                            [–]Better-Strike7290 13 points14 points  (3 children)

                                                                                            There will be.

                                                                                            Treatments like this usually target the cancers with the most diagnosis...which are skin and blood cancers. Lymphoma is YHE MOST researched cancer in history. Chances are, the mRNA for NHL is already in the works.

                                                                                            I have HL, and my oncologist is spearheading human trials for mRNA for HL right now, which is how I know.

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                                                                                                [–]BonusPlastic6279 399 points400 points  (7 children)

                                                                                                I recently lost my dad to cancer. This is great news and I hope something comes of it.

                                                                                                Fuck cancer!

                                                                                                [–]kc_______ 44 points45 points  (2 children)

                                                                                                Sorry for your loss, one day all or many forms of cancer will be seen as current infections that are treated with antibiotics, infections before antibiotics used to mean a death sentence for many people.

                                                                                                [–]Call_Me_At_8675309 5 points6 points  (1 child)

                                                                                                This. Finding that one way to stop the mechanism that bacteria use to replicate was what was needed for antibiotics. The same is true for cancer. For many, the self destruct mechanism of the cell is damaged and keeps replicating.

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                                                                                                  [–]AiurHoopla 401 points402 points  (30 children)

                                                                                                  Good. Fucking Vaxx me and make me cancer immortal. Ill do the testing

                                                                                                  [–]Mindless-Judgment541 89 points90 points  (19 children)

                                                                                                  Can't wait to hear what the anti vaxxers will come up with that makes it worse than cancer... But they will

                                                                                                  [–]queen-adreena 42 points43 points  (13 children)

                                                                                                  Isn't their whole spiel that autism (which definitely isn't caused by vaccines) is worse than polio/smallpox/death?

                                                                                                  [–]slog 45 points46 points  (1 child)

                                                                                                  I don't think they understand their own arguments anymore (if they ever did).

                                                                                                  [–]FILTHBOT4000 10 points11 points  (0 children)

                                                                                                  It's all a bunch of nebulous nonsense and moving goalposts, for which they'll never be held accountable.

                                                                                                  [–]TheBigWil 8 points9 points  (1 child)

                                                                                                  Jokes on them! I didn't need a vaccine to catch autism

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                                                                                                      [–]fabonaut 13 points14 points  (7 children)

                                                                                                      It works differently than common vaccines afaik. You'll get it after being diagnosed with the specific type of cancer.

                                                                                                      [–]PuckSR 4 points5 points  (0 children)

                                                                                                      Yeah, they already have some cancer vaccines that work this way and it is very confusing for people.

                                                                                                      https://www.roswellpark.org/cimavax

                                                                                                      People tend to think "vaccine"="prevent from getting in the future".
                                                                                                      But really "vaccine" = "train the body's immune system to do something using antigens"(viruses or other stuff that shouldn't be in the body). So in the case of most of these new mRNA cancer vaccines, you are training the immune system to attack cancer cells or remove stuff from the body that the cancer cells need.

                                                                                                      However, at the same time we also have a lot of new vaccines that are preventing the infection of viruses that lead to cancers(e.g. RSV).

                                                                                                      It is all going to get really confusing for people.

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                                                                                                          [–]Poop_Knife_Folklore 29 points30 points  (0 children)

                                                                                                          I hope this sort of stuff hurries along. we are all ticking timebombs for these sorts of health issues, And I sincerely hope if I ever need these, they will be available in time. I suspect we are on the cusp of being able to cure literally everything that can go wrong. such exciting times we live in!!!!

                                                                                                          [–]lovetheoceanfl 91 points92 points  (8 children)

                                                                                                          As someone who’s had two melanoma in the past year, thank fucking god for this.

                                                                                                          [–]dont_forget_canada 20 points21 points  (5 children)

                                                                                                          how did you know!

                                                                                                          [–]itsgrimace 24 points25 points  (1 child)

                                                                                                          A melanoma first presents as a small dark irregular mark on your skin, usually smaller than 1/4inch (I use the because it's easy to visualise a larger headphone jack). I had one removed last year too. Early detection saves lives.

                                                                                                          [–]lovetheoceanfl 6 points7 points  (0 children)

                                                                                                          Exactly this. I go to my doctor every three months now. I wear lots of sunscreen and try not to get a lot of - if any - sun exposure between 10 and 3.

                                                                                                          That said, knowing that this is a potential treatment and it’s only a year away is an incredible stress reliever.

                                                                                                          [–]visible_sack 15 points16 points  (1 child)

                                                                                                          The best way to know is to get a full-body check each year, ideally with a dermatologist that takes pictures each time because there's no way you can accurately track new and changing lesions on the skin overtime otherwise.

                                                                                                          This becomes even more important if you have a lighter complexion, were born or live where there's a lot of sun or work outdoors.

                                                                                                          The best prevention is wearing sunscreen, a wide brim hat and UPF clothing.

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                                                                                                              [–]Trygolds 446 points447 points  (148 children)

                                                                                                              I wonder if this works how many people will die because they are anti vaxers.

                                                                                                              [–]Darkality24 201 points202 points  (8 children)

                                                                                                              A friend of mine was an obsessive anti-vaxer. He told me I was commiting suicide when I got the shot.

                                                                                                              He was hospitalized with COVID when he had a stroke and now has severe brain damage. Being right doesn't always feel good.

                                                                                                              [–]Poop_Knife_Folklore 45 points46 points  (0 children)

                                                                                                              Sometimes going against medical advice because the internet told you so is a recipe for a darwin award.

                                                                                                              [–]aendaris1975 28 points29 points  (3 children)

                                                                                                              This is why I hate those morons who say they don't need a covid vaccination because they are in good health not understanding cumulative damage from repeated covid infections will change that really quickly.

                                                                                                              [–]Darkality24 13 points14 points  (2 children)

                                                                                                              Oh yeah. This fellow was a minor league hockey player. He was in amazing physical condition and had no underlying conditions.

                                                                                                              [–]Dependent_Cloud420 3 points4 points  (1 child)

                                                                                                              and thats where the arrogance stems from - he "was invincible"

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                                                                                                                [–]Cecil900 315 points316 points  (12 children)

                                                                                                                My dad died because he was an anti-vaxer.

                                                                                                                Two years later it’s exhausting still seeing the same nonsense getting repeated ad nauseam.

                                                                                                                [–]buntopolis 97 points98 points  (1 child)

                                                                                                                Sorry for your loss.

                                                                                                                [–]Crystalas 69 points70 points  (7 children)

                                                                                                                At this point I consider Oprah an evil on the world from the people she gave years of unparaleled soap boxes and legitimacy to dangerous people (and some outright criminals) at a time when this stuff was just starting. Like even by today's social media and Fox News standards Oprah's daily show is still hard to top for reach and influence. People still worship her, anything she endorses no matter how vapid or horrible becomes gold.

                                                                                                                If not for her it might not be even a fraction as large of an issue. Instead "Doctor" Oz, the King of Snake Oil and the only truth he tells is that doctors hate him, almost became my state's Senator last cycle. She was the "gateway drug" for a staggering number of women to new agers, conspiracy theories, and "alternative" medicine while profiting off desperate people. The damage done echoed across the western world.

                                                                                                                [–]dquizzle 12 points13 points  (5 children)

                                                                                                                On one hand you’re absolutely right. On the other hand, it’s not Oprah’s fault alone that so many people are complete idiots.

                                                                                                                [–]Dekar173 9 points10 points  (0 children)

                                                                                                                She definitely feeds into our modern day idiocracy.

                                                                                                                [–]zgolledge 8 points9 points  (0 children)

                                                                                                                I honestly think it could be

                                                                                                                [–]DJEB 4 points5 points  (0 children)

                                                                                                                While I’m frustrated with the extent to which some gullible people refuse to think, I can’t forgive her predatory profiteering off of the grifters she’s promoted. I’m struggling to think of a good example of symbiotic parasites as an allegory.

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                                                                                                                    [–]Komnos 12 points13 points  (0 children)

                                                                                                                    I saw an elderly woman on NextDoor wishing she hadn't gotten the vaccine even though her husband had died of COVID! She was convinced that she was shedding mRNA proteins or something, and I guess this was somehow worse than dying? Just infuriates me how the misinformation machine preys on vulnerable people like that.

                                                                                                                    [–]aendaris1975 13 points14 points  (0 children)

                                                                                                                    These people are completely obsessed with covid. Literally the entire world got vaccinated and moved on with life and now a minority of people keep clutching their pearls over mandated vaccination, masks, vaccine passports and lockdowns none of which have been happening for years at this point. They are absolutely crazy.

                                                                                                                    [–]Telemere125 124 points125 points  (16 children)

                                                                                                                    The exact right amount

                                                                                                                    [–]Zomunieo 62 points63 points  (46 children)

                                                                                                                    Anti vaxers can be very selective about vaccines they consider good or bad. Entirely possible some will take it because they’re more scared of cancer than a big scary needle, but they’re more scared of the needle than covid….

                                                                                                                    [–]FlatHatJack 85 points86 points  (36 children)

                                                                                                                    Work in a pharmacy. I've had people come in asking for a flu or rsv shot asking for the version "without that COVID poison" in it.

                                                                                                                    First, COVID shots and flu shots are 2 separate vaccines and have never been combined like TDaPs are.

                                                                                                                    Second, how do you didtrust the science behind this covid shot but not the same science of the flu shot you are asking for?!

                                                                                                                    [–]buntopolis 46 points47 points  (5 children)

                                                                                                                    One makes their God Emperor look bad.

                                                                                                                    [–]DreadLindwyrm 15 points16 points  (4 children)

                                                                                                                    For now.
                                                                                                                    I've heard suggestions that eventually they'll be rolling the COVID vaccination into the normal round of seasonal 'flu shots once there's a few more years behind everything.

                                                                                                                    Meaning *one* set of stabbing people in the arm instead of two, which has to be a good thing.

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                                                                                                                      [–]ButtBlock 12 points13 points  (1 child)

                                                                                                                      I’ve had several patients that have refused blood transfusions because they are worried about allo immunization against Covid-19. Because apparently the donor antibodies against Covid-19 are deadly???? Hmm never learned that in medical school.

                                                                                                                      [–]dinoroo 23 points24 points  (0 children)

                                                                                                                      They’ll take a handful of pills everyday and unironically tell you we don’t know the long term effects of vaccines.

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                                                                                                                        [–]adfx 3 points4 points  (0 children)

                                                                                                                        They will probably die because they have cancer

                                                                                                                        [–]aendaris1975 8 points9 points  (0 children)

                                                                                                                        Antivaxers are too stupid to save themselves.

                                                                                                                        [–]Crivos 17 points18 points  (0 children)

                                                                                                                        Darwin has entered the chat

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                                                                                                                          [–]Algae_Sweet 15 points16 points  (7 children)

                                                                                                                          Now do Alzheimer’s pls.

                                                                                                                          [–]AussieAK 16 points17 points  (6 children)

                                                                                                                          An immunotherapy for Alzheimer’s has been released recently

                                                                                                                          https://www.alz.org/alzheimers-dementia/treatments/aducanumab

                                                                                                                          [–]-HaroldBudd- 15 points16 points  (0 children)

                                                                                                                          A number of years ago I lost a good friend to melanoma. His name was Murray. And he was a good dude. Miss you Murray.

                                                                                                                          [–]WinthropH 128 points129 points  (17 children)

                                                                                                                          BUT what does Joe Rogan say? Has Joe Rogan approved this?

                                                                                                                          [–]Schubydub 83 points84 points  (15 children)

                                                                                                                          Give him some time to consult a couple veterinarians before he makes his decision.

                                                                                                                          [–]Gazzarris 28 points29 points  (2 children)

                                                                                                                          Aaron Rodgers doing some research for Joe.

                                                                                                                          [–]Joliet_Jake_Blues 11 points12 points  (1 child)

                                                                                                                          QAron Rodgers and Kirk Cousins both refused the vaccine and both tore their Achilles tendon.

                                                                                                                          I ran right out and got boosted because I like walking.

                                                                                                                          All my medical decisions are based on loosely related anecdotal information

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                                                                                                                              [–]DoingItForEli 9 points10 points  (0 children)

                                                                                                                              My friend's mom just died of cancer. Seeing this feels gut-wrenching in a way because so many lives like hers have been taken too soon and it feels like we're just on the verge of being able to cure people like her truly. Imagine someday being able to look on cancer the same way we look at polio.

                                                                                                                              Her service is today. She was like a mom to all of us.

                                                                                                                              [–]GTFOScience 16 points17 points  (9 children)

                                                                                                                              Does this stop someone from getting cancer or just make it less severe/more treatable?

                                                                                                                              [–]theoinkypenguin 18 points19 points  (0 children)

                                                                                                                              It’s a treatment, not a prophylactic

                                                                                                                              [–]Better-Strike7290 17 points18 points  (5 children)

                                                                                                                              It basically teaches your immune system how to identify and kill cancer cells and tumors.

                                                                                                                              Tumors grow because your immune system doesn't recognize them to be bad cells in need of destruction, and this "vaccine" straps the cancer of that.

                                                                                                                              Basically it will feel like one hell of a bad cold while your body kills it off...then you're cured.

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                                                                                                                                [–]bcrichboi 32 points33 points  (1 child)

                                                                                                                                Damnit, I knew i done fucked up going pfizer

                                                                                                                                [–]Joliet_Jake_Blues 11 points12 points  (0 children)

                                                                                                                                I started Pfizer but got Moderna boosters

                                                                                                                                My 5G is really like 15G

                                                                                                                                [–]Imherehithere 6 points7 points  (3 children)

                                                                                                                                I believe the current version in trial is only for melanoma. I hope the mrna vaccine conquers other cancers too.

                                                                                                                                [–]YayItsMaels 4 points5 points  (2 children)

                                                                                                                                They need to call it something other than a vaccine if they want everyone to take it. Not for your or me, but for them.

                                                                                                                                [–]Haquistadore 31 points32 points  (1 child)

                                                                                                                                Social media discussions five years from now:

                                                                                                                                iT’s a LiBeRaL CoNsPiRaCy tHaT OnLy CoNsErVaTiVeS DiE oF cAnCeR

                                                                                                                                [–]f8Negative 32 points33 points  (5 children)

                                                                                                                                Obligatory Fuck Cancer

                                                                                                                                [–]IAMSTILLHERE2020 10 points11 points  (0 children)

                                                                                                                                Hey don't mention "mRNA"....Anti Covid people will get scared.

                                                                                                                                [–]nokenito 6 points7 points  (0 children)

                                                                                                                                This is amazing!

                                                                                                                                [–]EmperorGrinnar 4 points5 points  (0 children)

                                                                                                                                Well. That's good news to wake up to. Sweet.

                                                                                                                                [–]TheComedianGLP 4 points5 points  (0 children)

                                                                                                                                Uh huh.

                                                                                                                                "I Am Legend" opening scene says what?

                                                                                                                                [–]Ok_Condition966 2 points3 points  (2 children)

                                                                                                                                That’s really good news, probably gonna cost one hundred thousand per treatment.

                                                                                                                                [–]GundamPanda84 3 points4 points  (0 children)

                                                                                                                                I wish this was discovered two years ago to save my brother.

                                                                                                                                [–]SilithidLivesMatter 3 points4 points  (0 children)

                                                                                                                                Wait, what? I have a neighbour who is a daily drinking alcoholic who had to get his dad to tow his truck out of a ditch and bring to his backyard to get fixed, because he's on thin ice with his insurance company for suspected DUI claims they couldn't prove. He says that vaccines are dangerous! Are you trying to say this guy is WRONG?!

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