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[–]goldmansachsofshit 220 points221 points  (82 children)

"The new study addressed some of those concerns. The researchers tracked immune responses in volunteers 29 and 239 days after the first inoculation. Ten of the study participants received only one dose of the J.&J. vaccine, while 10 others got a second dose of the J.&J. shot or an mRNA vaccine."

Does this mean the study included only 20 people? Anybody got a link to the study?

[–]angiosperms- 150 points151 points  (65 children)

[–]KaptainKorn 267 points268 points  (58 children)

that... doesn't seem like a big enough sample size.

[–]Jammyhobgoblin 47 points48 points  (26 children)

Only 4% of the US got it so I’m really curious how they are going to get around that issue.

[–]partiallycylon 80 points81 points  (15 children)

As one member of that 4%, I'd still like to know if I should start seeking an mRNA booster now, not 3 months later when it's suddenly scary to be inside again.

[–]SauronSymbolizedTech 23 points24 points  (10 children)

I recommend asking your doctor's opinion on it.

[–]partiallycylon 21 points22 points  (5 children)

I've done that already, they have so far just said "Follow CDC recommendations", which I believe and am alright with. But if the WHO starts questioning it, or if evidence starts to trend badly, before the CDC acts, I'll probably be a little more insistent. Meanwhile I think things are fine, I just thought I was done having to think otherwise.

[–]0220_2020 3 points4 points  (2 children)

I had the J&J in April and just got a Pfizer as a booster. I'm in Missouri which has a high number of Delta cases and low overall vaccination rates, especially in rural areas. I definitely don't feel clear about whether I did the right thing but atleast I'm no longer oveethinking.

[–]bedandsofa 1 point2 points  (1 child)

Exact same situation here and I made the same decision. I figure there’s still a 40% chance of breakthrough infection with just J&J alone, we can’t count on herd immunity in this state of misery, and all these doses would otherwise be garbage.

[–]0220_2020 1 point2 points  (0 children)

Here's hoping it works for us. I'm in bed with a migraine and fatigue but expect it to pass soon. Exact same thing happened after my J&J shot, 1 day of soreness and misery and then I was ok. Good luck to ya, this state is a little (ok a lot) nuts.

[–]x_xStay_Uglyx_x 18 points19 points  (1 child)

I’m in America I can’t afford a doctor

[–][deleted] 6 points7 points  (0 children)

well if you could afford one, they’d tell you to do whatever the man on TV says.

[–]laredelle 3 points4 points  (0 children)

I also contacted my doctor about this and he said to call their vaccine clinic. Called the vaccine clinic and they said to ask my doctor. Sigh

[–]Jammyhobgoblin 11 points12 points  (0 children)

I was in the same boat, but I figured they will tell us if it’s necessary just like they did with the blood clots. They seemed to have little issue scaring us half to death, so I don’t see why they’d hide it.

[–]Hitler_wuz_socialist 1 point2 points  (1 child)

I didn't even know that it was an option

[–]partiallycylon 1 point2 points  (0 children)

It would likely be safe (I say with no actual authority) and would likely give you a better immune response overall (I conjecture further without official knowledge) but they probably won't let you do it just yet. Especially since your first vaccination is definitely on record somewhere.

[–][deleted] -1 points0 points  (0 children)

I got it.

And the next day I could turn invisible and talk to animals.

[–]goldmansachsofshit 50 points51 points  (9 children)

no, it doesnt

[–]Schwarzer_Koffer 54 points55 points  (8 children)

For a clinical trial it wouldn't be enough. But when directly testing for a measurable immune response it is significant.

[–]goldmansachsofshit 0 points1 point  (2 children)

I guess i can understand that. But why not just include some more? They could add a couple hundred with little to no extra cost in terms of time or money i would imagine.

[–]Schwarzer_Koffer 12 points13 points  (1 child)

Ethical concerns. Studies where people are puposefully infected with a virus have to follow strict guidelines and always only allow for very few subjects that have to be tightly monitored.

[–]goldmansachsofshit 3 points4 points  (0 children)

Had no idea that this was how its done. In that case it makes more sense

[–]VegetableWest6913 19 points20 points  (5 children)

I've seen statisticians complain about people saying this. According to them, the sample size can be very low and still valid. Sample size alone doesn't rule out a conclusion.

[–]zUdio 2 points3 points  (1 child)

It can when your sample is 20 and your population is over 13 million people. That’s a pretty wide/bad confidence interval.

[–]VegetableWest6913 3 points4 points  (0 children)

This is exactly the conclusion the statisticians were complaining about lol.

[–]Ryoukugan 2 points3 points  (0 children)

In other words, a sample size so insanely small that it’s results are basically worthless.

[–]Hi_Dee -1 points0 points  (0 children)

I think this might be the pr team grasping at straws

[–]AccomplishedDust3 47 points48 points  (5 children)

This study isn't testing efficacy the way the big phase 3 trials were done, where you give a bunch of people the vaccine and see if fewer of them get sick with COVID vs a control group that didn't get the vaccine. Those trials need lots of people in part because not everyone is exposed to the virus, so you need a big sample even for a substantial number of the control group to get infected during the study.

What they did instead was to take just a handful of people who previously got the vaccine and check whether antibodies in their blood were able to bind and neutralize the virus in vitro. It's not the same kind of real-world evidence that the big trials give, but it gives a bench science data point in support.

https://www.prnewswire.com/news-releases/positive-new-data-for-johnson--johnson-single-shot-covid-19-vaccine-on-activity-against-delta-variant-and-long-lasting-durability-of-response-301324791.html?tc=eml_cleartime

It's not important to do this type of trial in a larger sample, but it is also difficult to connect this level of activity on the bench to real-world efficacy. It's much better news than if it didn't bind, of course.

I think better indicators will be if people who end up dead or hospitalized include substantial numbers of people previously vaccinated. So far I have only seen data on that in general, though, and not by specific vaccine type or COVID variant.

The study itself is here: https://www.biorxiv.org/content/10.1101/2021.07.01.450707v1.full.pdf It's just posted on biorxiv, not in a journal, so it has not been peer reviewed:

All tested variants demonstrated susceptibility to Ad26.COV2.S‐induced serum neutralization albeit mainly reduced as compared to the B.1 strain. Most pronounced reduction was observed for the B.1.351 (Beta; 3.6‐fold) and P.1 (Gamma; 3.4‐fold)

variants that contain similar mutations in the receptor‐binding domain (RBD) while only a 1.6‐fold reduction was observed for the widely spreading B.1.617.2 (Delta) variant.

Seems like better news for delta than the other variants they tested, but still not clear how exactly this will translate to the real world.

[–]Taswegian 5 points6 points  (0 children)

There is an international phase 3 trial underway for the J&J vaccine - 2 actually (1 dose and 2 doses). There’s data still being collected for both. I presume they are looking at any confirmed variant cases in the study participants, as well as other covid strains. Will be interesting to see how the results compare when they are published.

[–]goldmansachsofshit 0 points1 point  (3 children)

That makes more sense. Thanks for taking the time to break that down. Even still, why wouldnt they include more? Surely a couple hundred wouldnt cost significantly more in time or money

[–]jello_drawer 3 points4 points  (1 child)

Before making those kinds of assumptions you really should look at the experimental methods described in the paper and educate yourself with some basic understanding of how the process works. Also consider what the objective is and what you need to do to test your hypothesis. For each variant, run ten different dilutions, multiplied by a number of technical replicates, add positive and negative controls, and then do that for each serum sample tested. It's manual experimental work, not log each blood collection tube in a machine and get a result in a few hours, so you need an extensively trained person to do it. You also need to have collected enough serum to do it, and not have used the serum for other important work you might be planning. If you were planting a tree in hard, rocky soil and were asked to dig, with a shovel, a 2.5 foot deep by 2.5 foot wide hole to fill with better soil and the tree, would you dig a 10 foot by 10 foot hole? No. The larger hole would allow you to fill more rich soil, but it's not necessary for the purpose (the benefits are marginal and the costs are large.)

[–]goldmansachsofshit 1 point2 points  (0 children)

Thank you for offering more information

[–]bajesus 1 point2 points  (0 children)

These sound like two small studies done at hospitals probably by small teams doing multiple tests on each person's blood. Others are doing similar studies around the world that will be released in the future. In cases like this I'd much rather have a lot of different people doing small tests in different labs to verify each others results than one group of researchers doing thousands of the same test. You guard against faulty equipment and lab contamination the more labs/equipment you have running tests.

J&J is pushing this story as soon as possible because it's positive news and they hope it will help calm fears about the Delta variant a bit. They aren't going to wait until they have a dozen of these types of studies, or until they get some large scale spreadsheet science in on actual cases vs vaccine recipients, to put out press releases on this stuff.

In a few months we can get a more detailed meta-analysis of a bunch of these different studies. For now just look at it as a very positive early data point.

[–]Foyles_War 5 points6 points  (2 children)

I thought the J and J vax was the one dose vax? Are people getting two doses, anyway?

[–]ExcitingRise0 10 points11 points  (1 child)

I have have had two doses of J&J as part of ENSEMBLE 2, which is a clinical trial testing a double dose vs placebo.

[–]angiosperms- 345 points346 points  (25 children)

I decided to look this up since I got paywalled. The sample size for this study was 8 people lol

[–]T-Bills 21 points22 points  (12 children)

To be clear, this was an analysis of the Phase 3 ENSEMBLE trial that was already completed (and enrolled 44,325 people) and isn't a new study, so the % of infected people in the trial with the delta variant could be lower than the % now:

A preprint submitted by the Company today to bioRxiv contains a new analysis from blood samples obtained from a subset of participants (n=8) in the Phase 3 ENSEMBLE study. These data showed that the Johnson & Johnson single-shot COVID-19 vaccine elicited neutralizing antibody activity against the Delta variant at an even higher level than what was recently observed for the Beta (B.1.351) variant in South Africa where high efficacy against severe/critical disease was demonstrated.

https://www.jnj.com/positive-new-data-for-johnson-johnson-single-shot-covid-19-vaccine-on-activity-against-delta-variant-and-long-lasting-durability-of-response

I'd expect we'd hear more about each vaccine and their effectiveness against the Delta variant as it becomes more widespread, unfortunately.

[–]SnooOnions2433 -1 points0 points  (11 children)

4 of my family members in CO all vaccinated with Moderna got the Delta strain. One nephew was in ICU for 6 days. Remdisvir saved his life. I strongly suggest to keep masking up.

[–]bbennie 95 points96 points  (3 children)

An actual joke

[–]Christmas_Panda 19 points20 points  (0 children)

8 people seems unprofessionally low for something of this magnitude.

[–]46cmarm -1 points0 points  (0 children)

welcome to the media

[–]runningboomshanka 120 points121 points  (2 children)

Driving for press coverage with a size of eight people?? Seems...premature.

[–]agreensandcastle 8 points9 points  (0 children)

6 people had it pulled out of use.

[–]theqofcourse 34 points35 points  (0 children)

Headline should end in "... Company Claims."

[–]WhiplashDeath666 10 points11 points  (2 children)

Isn’t this the company that sold baby powder for decades knowing that it caused cancer in women?

[–]own3 61 points62 points  (28 children)

u are very_excited to post this - iam very glad to hear this.

(cause i was vaccinated J & J )

[–]RevRagnarok 31 points32 points  (6 children)

Same; my wife got it about two days before they pulled it. We've been saying she got the "Limited Edition."

[–]jakekorz 2 points3 points  (1 child)

I got it the day before lol. Perfect timing.

[–]RevRagnarok 1 point2 points  (0 children)

Based on your username, you probably didn't have to worry about the new warning for women under 50, but we did worry a tiny bit about it. Obviously not enough to not have her get it.

[–][deleted] 1 point2 points  (2 children)

Did they ever start offering it again?

[–]GoodQueenFluffenChop 11 points12 points  (8 children)

Same here. Got vaccinated back in April and was wondering if getting a booster from one of the other vaccines was needed.

[–][deleted] 13 points14 points  (3 children)

germans just reported that mixing vaccines is better than just getting one type. Just so you know.

[–]LazySyllabub7578 0 points1 point  (2 children)

Yeah, if I just had the J&J shot I'd want to get a Pfizer or Moderna on top of it. Personally I don't have alot of faith in the J&J shot. It seems to be 30-40% less effective than the MRNA shots with regard to Covid infection. Sure it protects against hospitalization and death but shouldn't that be the bare minimum? I'm more concerned about long covid and lifelong disability.

[–][deleted] 4 points5 points  (0 children)

Not sure why you are getting down voted. I feel the same way and got J&J back in March. I am looking to get a second shot from one of the others.

[–][deleted] 1 point2 points  (0 children)

The flu vaccine ranges 40% to 60%, anything over 60% is individually really good. It can imply that the body is weaponising the antibodies effectively.

Worrying about it being lower is way less important than how sick you can possibly sick. I would rather risk a mild infection than a severe one. Hospitalization rates is the one I watch.

[–]ltlvlge12 1 point2 points  (0 children)

Me too.

[–]Chemical_Ire -1 points0 points  (2 children)

Get a booster. Wife and I got our J&J in April too and we tested positive last Monday.

[–]lotusblossom60 14 points15 points  (1 child)

Me too. I’ve been worrying.

[–]vrschikasanaa 1 point2 points  (0 children)

I'm excited about this as well. I got Pfizer months ago and my fiance got J&J (before they temporarily pulled it), so he was fully vaccinated before me with the one and done. But lately I've been wondering if he should get the Pfizer as a booster, as well.

[–]FateUnusual 1 point2 points  (2 children)

The sample size for the studies were only 8 and 20 people.

[–]Schwarzer_Koffer 10 points11 points  (0 children)

If they injected 28 J&J vaccinated people with the virus and got a measurable immune response it is a significant finding.

[–]noimrighturwrongsorr 1 point2 points  (0 children)

Are you implying OP shouldn’t be happy?

[–]bodybagbitch 0 points1 point  (0 children)

Don’t just trust the title/headline. This study only tested 8 people.

[–]Chemical_Ire -1 points0 points  (2 children)

Don't count yourself safe yet. My wife and I got J&J on April 3rd. Here it is July 4th weekend and we both tested COVID-19 positive last Monday and are 6 days into isolation with our daughter.

[–]CritaCorn 13 points14 points  (0 children)

For those who want to know the sample size…20/8 people…in other news I watched paint dry.

[–][deleted] 6 points7 points  (2 children)

Waiting for all the gqp epidemiologists to come in and tell us way this is all libral bias. gets popcorn

[–]pianosportsguy 1 point2 points  (0 children)

Well, you'd think all those GQP scientists would have better things to do, but ya never know. They seem to spend an inordinate amount of time on social media. Must have gotten a NIH grant or something.

[–]AnotherScoutTrooper 0 points1 point  (0 children)

Damn, you’ve already painted anyone concerned about the low sample sizes as all of the -ist and -phobic words, shit I guess the delta variant will just disappear due to your valiant keyboard fighting.

[–]mleibowitz97 7 points8 points  (0 children)

Both are small studies, but hey its better news than it just not working

[–]QwithoutU1982 24 points25 points  (78 children)

It's great that we have official confirmation of this, even though it was already pretty obvious considering that nearly ALL recent covid hospitalizations and deaths have been unvaccinated people.

[–]bbennie 5 points6 points  (10 children)

The studies are with a sample size of 20 and 8 so definitely not enough to confirm

[–]QwithoutU1982 5 points6 points  (9 children)

Its enough when it's combined with all the other data. We know the J&J vaccine works because people who've received it simply are not ending up in the hospital or dying from covid.

[–]LegacyAngel -1 points0 points  (65 children)

This is disinformation

Not from delta variant.... Once you are hospitalized, the vaccine doesn't help at all because you might be at risk from long term damage (none of them). Look at the UK cases (200 deaths as of last week, and 49% were fully vaccinated). (Note this applies only to 50+ in age).

Now the vaccines do provide protection from being hospitalized in the first place. But delta variant can kill even vaccinated people in comparable numbers.

Edit : https://www.businessinsider.com/vaccinated-among-delta-deaths-but-older-relatively-few-uk-data-2021-6

This article has UK and WHO officials advocating for mask usage even if fully vaccinated cuz of new data from Delta.

Edit 2:

Wear masks indoors because delta has breakthrough potential. Literally just advising caution like WHO and NHS are saying

Edit 3: guess the CDC agrees with me now. 25 days later

[–]QwithoutU1982 0 points1 point  (64 children)

This is antivaxx propaganda largely gathered through adults who were only partially vaccinated when infected and manipulated stats. Don't fall for it, don't spread it. Listen to the CDC

https://www.cdc.gov/coronavirus/2019-ncov/vaccines/fully-vaccinated.html

https://thehill.com/policy/healthcare/560871-cdc-director-vaccinated-people-safe-from-delta-variant-do-not-need-to-wear

[–]LegacyAngel 0 points1 point  (63 children)

Are you saying that the NHS is lying when it said it had 50 delta deaths in fully vaxxed people last week? Cuz if that is your argument, you are living in a fake world. Delta is a scary variant. Get vaxxed and still wear masks indoors.

That CDC page makes no mention of delta.

The news article is literally contradicting the new findings from NHS and WHO.

So your data is outdated.

Yes Delta prevents hospitalizations. But once hospitalized, you are fucked.

You are saying I am spreading propaganda when it was confirmed by the NHS. Last week, of all hospital deaths, 30% were unvaxxed, 20% had one dose, 49% had two doses. This doesn't mean that the vaccine makes you more vulnerable. There are just more vaxxed people.

Edit: the deaths were all elderly people tho.

[–]QwithoutU1982 0 points1 point  (62 children)

I'm telling you that trying to conflate a partially vaccinated population in Europe to a fully vaccinated population in the US is deliberate data manipulation for the express purpose of seeding distrust in vaccine efficacy. Stop it.

In the US, almost ZERO recent hospitalizations and deaths are in fully vaccinated adults. You screaming about unrelated data does not change that. Get outta here with your antivaxx nonsense.

Your anxiety disorder does not make you more credible than the CDC. Period.

[–][deleted] 3 points4 points  (0 children)

Woot that’s what I got!

[–][deleted] 1 point2 points  (0 children)

Just like "no more tears".. That shit used to burn..

[–]mottlymonical 1 point2 points  (0 children)

Hahaha yh like I'll trust that. I don't trust any of this bs. However I got vac cuz I ain't stupid

[–]mrbill317 4 points5 points  (3 children)

Sure just like their Talc powder my mother in law trusted to be safe.

[–]Lukaroast 1 point2 points  (1 child)

What kind of idiot would actually think J&J is out to help them after everything that has come out over the years about them. I’m not even anti vax, I’m just not a complete moron who is gonna pretend that companies like that just suddenly change their ways

[–]Pillonious_Punk 2 points3 points  (5 children)

What does that mean for those who got one of the other vaccines? Am I going to have to start collecting every vaccine out there in my blood?

[–]TheS4ndm4n 11 points12 points  (0 children)

All the US/EU approved vaccines are fine so far. Some of the Chinese ones seem ineffective against delta.

[–][deleted] 6 points7 points  (0 children)

Follow the trends in Israel, they are like 90-95% vaccinated and believe in science. The vaccines are effective, if a little bit less so against the delta variant. I'm waiting for the omega variant that will wipe us all out tho

[–]janethefish 2 points3 points  (0 children)

Basically everything i have read points to all vaccines having most of their effect vs Delta.

[–]Lukaroast 0 points1 point  (1 child)

I will literally never trust a single thing that J&J claims. Why should I? They’ve made a habit out of concealing terrible things that they know are harmful and they deliberately put in their products. What kind of moron trusts the same corporate structure after that??

[–]GreyShot254 4 points5 points  (0 children)

8 person sample size, ok.

[–]Pahasapa66 3 points4 points  (6 children)

Without an efficacy, this article is garbage.

[–]happyscrappy 12 points13 points  (0 children)

They measured immune responses directly. The efficacy should be similar to that of what they compared against because the immune response was similar.

[–]scottieducati 6 points7 points  (3 children)

One could easily argue the efficacy figures posted by some of the other vaccines were rather inflated given the relatively low lack of infections at the time of study. Efficacy numbers mean very little without context.

[–]Pahasapa66 -1 points0 points  (2 children)

You could argue that, but there efficacy numbers for delta with one dose and two dose of Pfiser and Moderna and there's a big difference. For J&J to say its effective against Delta is kind of meaningless. How effective? There are some single dose vaccines that are only 40% effective against Delta.

[–]Farlander2821 5 points6 points  (0 children)

J&J has not finished their efficacy trials yet, so that data does not exist, but since questions about if J&J even worked at all against Delta were still being asked, as that was not known, they went ahead and published data showing it was. It is pretty useful because it shows that it's not strictly necessary for all J&J recipients to go and get an mRNA shot right now and can probably afford to wait for the efficacy results

[–]scottieducati 1 point2 points  (0 children)

I’m sure all the data will come out once the study is reviewed d published.

[–]a_sexual_titty 2 points3 points  (1 child)

Yer mom protects against the Delta Variant.

[–]SymbioteAD 1 point2 points  (1 child)

Take it with a grain of salt. My father-in-law got the J&J single dose about 3 months ago, and as of yesterday he tested positive for covid. Very minimal symptoms besides a 101 fever

[–]FoxFourTwo 1 point2 points  (2 children)

It should be highly illegal to paywall information such as this.

Protip: Ctrl+A, Ctrl+C, open notepad, Ctrl+V. Theres the article. Fuck NYTimes.

[–]JennJayBee 0 points1 point  (4 children)

Glad to see this. We all three got the mRNA vaccines, and I knew that they specifically targeted the spike protein. But I know the J&J vaccine is a more traditional vaccine, so I was wondering if folks would need a booster for this variant.

[–]happyscrappy 20 points21 points  (1 child)

J&J is a viral vector vaccine. Not terribly traditional. Both mRNA and viral vector vaccines work by delivering snippets of RNA for your body to key to. The viral vector vaccine just puts them in an unrelated virus and when that virus pops open the RNA comes out. With mRNA the vaccine programs one of your own cells to produce the RNA instead.

There are only a few traditional (live/attenuated) virus vaccines out there so far and they do not work as well. The Sinovac one, for example is of this sort. They do not work as well because with those vaccines the section of RNA your body should key to cannot be as well controlled.

[–]JennJayBee 2 points3 points  (0 children)

Interesting. TIL.

[–]HiCZoK 0 points1 point  (1 child)

I've heard this about every of 4 types of vaccine now.... No way of knowing which one is the best from media. It's a shot in the dark

[–][deleted] 3 points4 points  (0 children)

They're all very good, so "shot in the dark" isn't the best description.

[–][deleted] -1 points0 points  (0 children)

Are we expected to believe anything Johnson & Johnson says? Especially with such a small sample size?

[–]tehmlem -4 points-3 points  (2 children)

We are getting lucky. If we keep letting variants spread, we won't be.

[–]Eder_Cheddar -1 points0 points  (0 children)

Johnson and Johnson has literally given people cancer.

Fuck these people.

"Our vaccine is better because we sat so."

[–]DueAnimator6988 -4 points-3 points  (0 children)

I heckin love big pharma

Edit: Wow, gold!? Thank you kind gentlesir!

[–]LittleGreenBaggy -3 points-2 points  (0 children)

Johnson & Johnson can't even make a safe baby powder and they expect us to trust them with a vaccine?

https://www.nytimes.com/2018/07/12/business/johnson-johnson-talcum-powder.html

[–]Ok_Celery2582 -1 points0 points  (0 children)

Lmao we will see how I do against. I will be updating so stay tune….

[–]tercra -1 points0 points  (0 children)

I got the J&J and waited 6 weeks before I stopped wearing a mask in public. Two weeks after I got sick but didn't get concerned until I couldn't taste. Two days later I got tested and the results came back negative.

I have no idea what the hell is going on.

[–]Kellye8498 -1 points0 points  (0 children)

I’ll bet it does! After all of the bad press from the blood clot scandal I’ll bet it also cures stupidity.

[–]MammonStar -4 points-3 points  (0 children)

gotta recoup the lost profits from the blood clot debacle somehow

[–]VehaMeursault -2 points-1 points  (0 children)

Cool. Does anyone other than the company who wants to sell it report this?

[–]monclerman -2 points-1 points  (0 children)

But our baby powder still has heavy metals and caused cancer for generations. If you get the J&J or any vaccine for that matter , you trippin

[–]HugeHouseplant -2 points-1 points  (3 children)

Doesn’t even offer decent protection against the old strains

[–]mannymanny33 3 points4 points  (2 children)

so did you actually read the article?

[–]HugeHouseplant 3 points4 points  (1 child)

No I’m a redditor

[–]Morkidan1337 -2 points-1 points  (0 children)

10 years later you will hear it also causes cancer like their talcum powder

[–]ImaMartian -2 points-1 points  (1 child)

So would have exercising, but hey what do I know

[–]MrGurbic 1 point2 points  (0 children)

Clearly not a damn thing.