×
top 200 commentsshow 500

[–]AutoModerator[M] [score hidden] stickied commentlocked comment (0 children)

This post appears to be about vaccines, please see our FAQ for answers to frequently asked questions regarding the COVID-19 vaccines. Any comment containing misinformation will be removed and the user potentially banned.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

[–]CthulhusIntern 1359 points1360 points  (147 children)

If I'm reading this right, it should be approved tomorrow, right?

[–]phostyle 555 points556 points  (109 children)

Not until after VRBPAC meeting Friday

[–]crimsonkodiak 336 points337 points  (106 children)

Yes. Meeting Friday and then formal approval 1-3 days after that.

[–]CthulhusIntern 170 points171 points  (101 children)

Real days or business days?

[–]crimsonkodiak 179 points180 points  (28 children)

Real days. It happened the day after for Pfizer (after having been moved up from 2 days after).

Given that the meeting is on a Friday it's possible that it slips to Monday, but I'd be shocked if it's any longer than that.

[–]ChaplnGrillSgt 60 points61 points  (24 children)

I'd imagine EUA on Saturday and doses shipped on Monday.

[–]notayogaguy 55 points56 points  (13 children)

I think Pfizer was a Saturday and Moderna was a Sunday. But after the FDA approves it, the CDC has to, too.

FDA scientists complete their analysis (today) > ACIP looks at that and gives their recommendation (tomorrow) > VRBPAC looks at their conclusions and decides (Friday) > FDA leadership decides based on VRBPAC (Friday night or Saturday) > CDC decides to send it out (Saturday or Sunday)

[–]Vagabond21 5 points6 points  (3 children)

That’s how it was at our hospital. The Pfizer meeting is was on a Friday, I think, and by Tuesday of the following week people at work started getting jabs.

[–]afops 11 points12 points  (4 children)

Why aren’t millions of doses shipped long ago and just waiting in refrigerators everywhere? Does shipping really need to wait for approval?

[–]thespiderghosts 8 points9 points  (1 child)

As soon as it leaves the manufacturer you've lost control and becomes a lot of work to pull back. Even in EUA situations they'll hold it until then as far as I'm aware.

[–][deleted] 7 points8 points  (1 child)

Can they go ahead and be shipping them where they need to be in the mean time? If so, it really doesn’t matter if it’s approve tomorrow or Monday, as long as they can ship them now they can be in arms next week.

[–]FabriFibra87 109 points110 points  (2 children)

Looks like it, or at least Thursday was the official approval date I'd heard of. Staying cautiously optimistic.

Edit: apologies, that was reported over local NY news channels yesterday; today they're saying Friday

[–]ertri 33 points34 points  (1 child)

ACIP meets tomorrow, looks like approval may be this w though.

[–]Peas63 26 points27 points  (6 children)

The FDA Advisory Committee meets on the 26th. Expect an EUA later Friday evening, similar to the last two vaccines. The ongoing ACIP meeting is a standard, scheduled meeting to discuss other vaccines. COVID-19 isn't on the agenda. It's not publicly announced, but I assume there will be an ACIP meeting on Saturday, again similar to the other two vaccines, in which they would make recommendations for use. The CDC Director would then accept those recommendations on Sunday morning, after which the vaccine can be administered. What I've heard from my contacts at Janssen are that they won't be shipping out until at least a couple days into March.

Edit: ACIP is scheduled to meet 2/28 - 3/1, it is public but not posted in the same place they normally do; that would push the ACIP recommendation to Monday the 1st and CDC Director might not adopt and publish in the recommendation in the MMWR until the 2nd.

[–]dragoncatI'm fully vaccinated! 💉💪🩹 44 points45 points  (5 children)

At first I was disappointed at not being able to ship until a couple of days into March but I realized that’s just next week. Crazy how time flows in a pandemonium....

[–]badassery11 840 points841 points  (125 children)

CNBC: The company said the vaccine prevented 100% of hospitalizations and deaths.

Guardian: though the vaccine was 85% effective overall in stopping severe cases of the disease, the federal regulator said.

These figures are being widely circulated so not just these sources.

Can someone explain what the gap is in 100% of hospitalizations being prevented yet only 85% of severe cases? What's considered a severe case?

Sorry if this has been answered before.

[–]MerchU1F41C 607 points608 points  (92 children)

Severe cases were defined as "a positive Covid-19 case, plus an elevated heart rate at more than 125 beats per minute, elevated breath rate at more than 30 breaths per minute, or oxygen saturation below 93%)"

(Source)

[–][deleted] 36 points37 points  (2 children)

I've gotten BPM above that rate when I've had a flu or a bad cold before. My Garmin watch was telling me I was burning 5,000 calories from bed lol, probably assuming I was spending my entire day jogging.

[–]Joe_Pitt 4 points5 points  (0 children)

Above 125 at resting? Dang.

[–]406_realist 32 points33 points  (0 children)

I’ve read somewhere , can’t remember where, that the clinical line for a severe case is pneumonia.

[–]syncopacetic 108 points109 points  (13 children)

Post "mild" covid 7 months now and let me tell you, it gets pretty fucked up before they'll hospitalize you if you have zero or very low risk factors. I thought I was going to die in front of my fiance on my bed on the worst night. I was down to an oxsat of 90% and when I coughed I couldn't breathe back in. I am basically slowly starving to death due to the long term side effects. At this point I wish it were not slowly, I am so god damned miserable.

[–]Meghanshadow 40 points41 points  (2 children)

I’m sorry, I hope you improve soon.

Is loss of smell/lack of appetite a Long term effect for you? One of my cousins can still hardly eat because everything tastes like grainy cardboard or gluey slime.

[–]Zuikis9 25 points26 points  (1 child)

Have you had the vaccine yet? I am seeing anecdotal reports of long haulers feeling better after getting the vaccine. Still waiting on scientific study for confirmation though.

[–]syncopacetic 14 points15 points  (0 children)

No, even though I have a recorded life long history of issues involving my lungs, my age, the fact that I wasn't hospitalized and even the god damned fact that I already had it puts me on a back burner for any lists I have found and added my name to.

[–]TaurielsEyes 6 points7 points  (5 children)

What are the long term side effects that cause starvation? Thats new to me.

[–]HobbiesJay 13 points14 points  (0 children)

From my experience between the coughing, fatigue and nausea keeping food down was literally impossible while I had covid and my appetite has shrunk and is much smaller than where it was before. I'm lucky and have had my smell and taste return very quickly but if their post symptoms are that severe than I can only imagine how difficult eating and keeping food down is. I still get hit with waves of nausea that make it hard to not vomit out of the blue.

[–]syncopacetic 12 points13 points  (1 child)

It's more of a side effect of side effect. I have no desire to eat what is almost entirely disgusting now. The only thing I can eat and not quite literally gag down is a particular type of cookie, and only up to a certain point. I'm usually a binge eater with chubby weight issues so this is...idk. At first it was like, yay, it did something helpful but I'm rapidly entering emaciated territory and I have difficulty giving a fuck.

[–]fishlicense 5 points6 points  (1 child)

Because covid damages the blood vessels, and if you happen to get this damage in the blood vessels that supply the GI system organs, then those organs are going to have a hard time. For example people whose mesenteric artery was damaged during covid had to have entire sections of their intestines cut out because the intestine tissue had literally died and developed gangrene from insufficient blood supply, and they had begun to become so unable to eliminate the feces that it was starting to come out as vomit.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571302/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659807/

[–]Fuschiagroen 4 points5 points  (0 children)

Omg this is effing horrifying

[–]Wizmaxman 36 points37 points  (3 children)

Complete guess but: you goto the ER and need to be given oxygen. You get it, feel better and leave. You are not admitted to the hospital.

That might be a "severe" case but the company PR would spin it as not needing hospitalization.

Again - just spit balling here. Need to be careful when companies say thing because they are going to always have a marketing spin to it.

[–]Sqwilliam_Fancyson 109 points110 points  (7 children)

What implications do these emergency approvals bring up? Like what's done differently in the review process between a product thats given normal vs emergency FDA approval? (Beyond the time it takes)

[–]RenegadeRabbit 39 points40 points  (6 children)

[–]Sqwilliam_Fancyson 50 points51 points  (5 children)

Gotcha. So it is truly a "oh thank god" approval. Understandable, but yeah.

[–]desenagrator_2 743 points744 points  (91 children)

3 vaccines approved just a year after a brand new virus is found. Science is awesome.

[–]rocketwidgetBoosted! ✨💉✅ 286 points287 points  (41 children)

Also more broadly, getting these long-studied vaccine techniques to an approved state probably laid the groundwork for a similarly fast or possibly faster response when the next unknown disease is found.

[–]BetterCalldeGaulle 28 points29 points  (1 child)

Oh and the new tech used in the moderna and pfiser can be used for custom cancer treatment they can design off your own cancer cells in two days.

[–]eric987235Boosted! ✨💉✅ 14 points15 points  (0 children)

Or get a working bird flu vaccine before that fucker has a chance to wipe us all out.

[–]desenagrator_2 76 points77 points  (8 children)

I think for this being the first major global pandemic of our lifetime, we're doing pretty damn good. Could we do better? Of course, but this compared to the bubonic plague or spanish flu has been a walk in the park.

[–]rocketwidgetBoosted! ✨💉✅ 32 points33 points  (1 child)

Oh yes no doubt, I was intending to praise not criticise.

What I mean is, for example, we wouldn't have been able to make a COVID-19 mRNA vaccine at all just a few years ago, and now we have proven we can. And one of the advantages of mRNA is you can develop a prototype vaccine extremely quickly, on the order of days (before trials and production).

[–]desenagrator_2 6 points7 points  (0 children)

Most definitely! Pretty amazing how far advancements in medical technology has come.

[–]riemannrocker 14 points15 points  (0 children)

We're doing well in the realm of vaccines, for sure. I don't know if we're doing well overall.

[–][deleted] 12 points13 points  (3 children)

The US should have been able to reopen in May, this is a disaster.

[–]420blazeit69nubz 27 points28 points  (10 children)

It truly is fucking astonishing how fast this was all done.

[–]ekaceerfBoosted! ✨💉✅ 16 points17 points  (2 children)

It's even crazier when you find out that the vaccines only took a couple days to develop. The reset of the time was months of testing

[–]figandmelonBoosted! ✨💉✅ 10 points11 points  (14 children)

I’m curious which one is the best/safest to get. My daughter has severe food allergies and a history of cancer and I’m trying to figure it out. I don’t want to trigger a reaction or potentially new allergies but I equally don’t want her to get COVID as she is at a higher risk of severe symptoms.

[–]crimsonblade55 10 points11 points  (5 children)

Here is some info on the two approved vaccines including who should not get them:

https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/Pfizer-BioNTech.html

https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/Moderna.html

Since this one hasn't officially been approved yet officially it doesn't have this same info. From what I'm reading though it might not be quite as effective, but it only requires a single shot and can be stored at much more manageable temperatures. It's also a virus vector vaccine instead of mRNA which could possibly mean that this particular vaccine could be an issue for people with egg allergies, but I can't say for certain.

[–]brvopls 6 points7 points  (1 child)

If you’re concerned, please discuss that with her physician or care team. As much information as Reddit can provide, no one will be able to accurately provide that advice as those who have a medical education and know her case personally.

[–]blitzkrieg4Boosted! ✨💉✅ 23 points24 points  (3 children)

Going to be the "actually" guy and say the virus had been sequenced over a year ago, which is why we were able to develop the MRNA vaccines so quickly.

[–]Jaseoner82 18 points19 points  (1 child)

These vaccines have been in the works for years. The issue has been ADE in previous attempts. There’s been conflicting information about this issue since the release of these vaccines but is a very important conversation to have for proper informed consent

[–]blitzkrieg4Boosted! ✨💉✅ 4 points5 points  (0 children)

True, but the coronaviruses they were targeting before this time last year were different.

[–]dontKair 170 points171 points  (2 children)

The staff report is meant to brief the FDA’s Vaccines and Related Biological Products Advisory Committee, which will meet Friday to review J&J’s request for emergency use.

[–]311heaven 52 points53 points  (0 children)

Cool. Hook it up!

[–]evaughan 363 points364 points  (14 children)

Look, If you could get, one shot, or one opportunity, to freeze Covid like you wanted, in one moment, would you get vaccinated, or just let it slip?

[–]BallsDeepWithKenny_G 110 points111 points  (8 children)

Mom’s spaghetti

[–]dankhorse4 16 points17 points  (6 children)

Knees weak

[–]tillmedvind 12 points13 points  (2 children)

Vomit on his sweater already

[–][deleted] 14 points15 points  (2 children)

Time's up, RNA, PLOW!

[–]Distinct-Location 9 points10 points  (1 child)

Yo
His palms are sweaty, lungs weak, cough is heavy
There's mucus on his sweater already, not spaghetti
He's nervous, but on the surface he was calm and ready
To get vaxed, but he kept on forgettin'
While he goes down, the siren goes so loud
He opens his mouth, but the words won't come out
He's chokin', how, everybody's jokin' now
The clocks run out, times up, over, blaow

[–]LatissimusSaucy 222 points223 points  (34 children)

Just received my Johnson and Johnson shot today.

Hope it is approved soon! Much love from South Africa.

[–]new_start_2020 65 points66 points  (4 children)

Nice. I can't wait till I get a Johnson in me too

[–]LatissimusSaucy 20 points21 points  (0 children)

Nice mate! Hope it’s soon! Enjoy the long but satisfying jab ;)

[–]AllThoseSadSongs 19 points20 points  (16 children)

How were your side effects? My friends are all in their thirties who got the shot and had gnarly side effects with the first two and had to take off of work. If this one is easier, I'll go after that. If I take off of work, they have to close my classroom, so if I can avoid that, it saves fifteen parents from having to find out at 730am that their child's classroom is closed!

[–][deleted] 15 points16 points  (1 child)

I'm in my 40s and I had the Pfizer. The first shot wasn't bad, just a sore arm and a little lethargy. The second shot was less arm pain but with dizziness and a 102 degree fever for about 8 hours. The fever kept me up all night and I was pretty exhausted the next day. My wife had the Moderna and had a similar experience, but with less fever and more of a severe headache. It was worth it, but was rough.

[–]AllThoseSadSongs 5 points6 points  (0 children)

My buddy was similar to you but for eighteen hours. Fevers are tough because even if you feel good, you flunk the temp check at the door and get sent home.

[–]scienide 6 points7 points  (1 child)

IIRC feverish side effects, chills etc. are usually a good sign as this indicates a strong immune response, i.e. the vaccine is doing its job.

[–]shana- 32 points33 points  (7 children)

How exciting. So happy for you! I’m going today for my first Pfizer shot. 👍🏽

[–]robotboy199 15 points16 points  (5 children)

im going for my first moderna shot later hopefully. if anyone has anything to share regarding side effects please let me know how it was for you

[–]LatissimusSaucy 8 points9 points  (0 children)

Yay man! Happy for you too!!!

[–]Maangamadaiyan 85 points86 points  (22 children)

Would it be possible to get a J&J shot followed by Pfizer / Moderna at a later date?

[–]ryanstrikesback 41 points42 points  (5 children)

That would be ideal if it works, but honestly after the last 12 months....you can poke me with J&J twice a year until the end of time.

[–]Credit-Limit 12 points13 points  (4 children)

I have a feeling annual covid boosters may be a thing from now on.

[–][deleted] 7 points8 points  (0 children)

In the trial and considered doing this, but decided against it. For now I’ll go with the J&J single shot and expect sometime in the fall there will a variant booster that could be a mRNA vaccine.

I see a more difficult problem with repeated adenovirus vector shots than mix and matching mRNA vaccines. This is more because the immune system will eventually start attacking the adenovirus vector if it is used for multiple shots.

[–]ocbro2 132 points133 points  (4 children)

There were no reports of anaphylaxis

Also promising for those predisposed to allergic reactions.

[–]chrisjozo 44 points45 points  (3 children)

Both this and the Oxford one showed no sign of Anaphylaxis I believe. It's good that there will be options for people with allergies.

[–]blackether 46 points47 points  (2 children)

Pfizer showed 4.7 reports of anaphylaxis per million doses, and Moderna showed 2.5 reports per million doses. 66 total reports of anaphylactic reactions across 17,524,676 actual administered doses Dec-Jan based on this paper on jama. A majority of these cases reported having other significant allergies, and nearly all were women. Initially, Pfizer estimated 11.1 anaphylactic reactions per million doses, so it reduced noticeably down to 4.7/million in practice.

The Johnson & Johnson study group was only 40,000 so there is a strong chance that they may not have reported any cases of anaphylaxis anyway if it caused it at the same rates as the other vaccines. Early study participants could not have COVID-19 comorbidities. Later study participants also were screened for comorbidities and had to be otherwise approved if so, meaning there would have been a lower effective rate of comorbidities than within the general population.

My interpretation is that the data they've provided does not directly indicate J&J is any safer for the highest risk-group for anaphylaxis than the other vaccines, however, all three have very low rates of causing anaphylaxis. Additionally, this (the potential for anaphylaxis) is precisely why everyone is required to wait around after receiving a vaccine dose, so if you do have a reaction you can receive immediate medical attention.

Of course, if you have significant allergies you should probably consult with your doctor - however, if you just have a peanut allergy, the mRNA vaccines are very likely not worse than waiting for J&J.

[–]AngylizyI'm fully vaccinated! 💉💪🩹 157 points158 points  (11 children)

Awesome possum

[–][deleted] 69 points70 points  (4 children)

Now let's turn this possum into a busy bee

[–]Nigdamus 21 points22 points  (3 children)

Let’s turn that bee into a Chatty Cathy and get the word out

[–]Rollingbeatles75 16 points17 points  (2 children)

Let's turn that Cathy into a Shooter Steve and start getting some shots in some arms.

[–][deleted] 12 points13 points  (1 child)

Let’s turn that Steve into an Average Joe and get most of the population immune!

[–]Rollingbeatles75 13 points14 points  (0 children)

Lets turn that Joe into a Raging Ron and fucking rage this Summer.

[–][deleted] 9 points10 points  (0 children)

Possums are awesome

[–]CatDad69 545 points546 points  (200 children)

One shot, that's overwhelmingly protective against severe and moderate disease. This is so cool. The scientists who did all of this in one year really deserve kudos.

By spring, America will be semi-normal. By July 4, we'll be ... America again.

[–]I_trust_everyone 250 points251 points  (56 children)

We’re gonna have a big ass party this year

[–]chriswaco 142 points143 points  (34 children)

If I were in charge I’d put an extra $1B for July 4th fireworks in the covid bill.

[–]Rivster79 9 points10 points  (1 child)

And we can use all of the makeshift Covid hospital beds as burn wards!

[–]needtoaskaquestion45 43 points44 points  (29 children)

(unsure if this is against the rules) I agree with the interpretations of this thread, I don't see why things shouldn't be normal in the US by summer. Yet, I have a wedding planned, large, indoor, end of August, NY, no anti-vaxxers. thoughts? (we are still considering postponing, ultimately it feels like the "right" choice, but I don't want to postpone for no reason. it could potentially be the party of the century)

[–]chriswaco 25 points26 points  (1 child)

I am not a biologist nor an epidemiologist and even they don’t agree when this will be over. As an engineer, I think you’ll be fine in August based on the number and efficacy of vaccines that will be available by then.

[–]itsdangeroustakethis 11 points12 points  (2 children)

I'd think worst case scenario you may have some masking in the casual photos. Do you have the option to open the windows or anything for extra ventilation?

I'm planning a small, outdoor wedding for July and waffling on whether I need a mask as part of my outfit...

[–]jonsconspiracy 10 points11 points  (3 children)

I think we're pretty much in the clear by May. Yeah, not everyone will be vaccinated, but enough will that the spread will decrease substantially. Then we'll go through a few ackward months of people slowly taking masks off and going back to work as normal. By Labor Day, we'll basically be back to whatever the new normal is and all restrictions will be lifted (int'l travel, concerts, sporting events, mask mandates, etc.).

That's my expectation. Check back on this in 7 months and we'll see if I was correct.

[–]OPACY_Magic 64 points65 points  (7 children)

Have your wedding and require proof of vaccination for entrance. And go have the time of your life.

[–]Thegiantclaw42069 10 points11 points  (10 children)

Ya ill belive that when I actually get the vaccine this year. Not sure why "essential" workers are last in line.

[–]PobodysNerfect802 5 points6 points  (6 children)

What state are you in? Everyone I’ve heard about has essential workers in earlier groups. I’m a 55-year-old woman with no conditions and not in an essential profession so I know what last in line looks like.

[–]jack-o-licious 31 points32 points  (2 children)

The scientists who did all of this in one year really deserve kudos.

Not even a year. The vaccine was developed around May/June last year. All the time since then has just been spent on trials.

[–]_BarryObama 79 points80 points  (54 children)

Nice to see the optimism on here. For some reason twitter, or at least my timeline, has adopted the view that there's no chance we're out of the house this summer, it's always haha the US sucks no way this thing ends soon. If people want to be home for the rest of eternity that's fine, but the rest of us will resume our lives post vaccine.

[–]rdmc23Boosted! ✨💉✅ 43 points44 points  (3 children)

for some reason Twitter

Well there’s your mistake there. Twitter is really toxic. The only value I have with Twitter is the lightning speed news it delivers. Tiger Woods was trending on my feed even before the major news outlet broke it. Same with Kobe.

[–]_BarryObama 14 points15 points  (1 child)

Agreed, twitter is nice to follow live events and also the occasional funny viral trend, but the covid discussion is off the wall

[–]FroZnFlavr 4 points5 points  (0 children)

any political discussion is “off the wall”

[–]406_realist 54 points55 points  (31 children)

People are addicted to being miserable. How many of these same pessimists were on record a little over a year ago saying “there won’t be a vaccine for two years !” ?

[–]_BarryObama 42 points43 points  (14 children)

Funny thing is, people say we should follow the data and science, which I have always agreed with. Well the data and science say that vaccines work, cases are going down, and also that this is potentially a seasonal virus. Vaccines out = open up.

[–]VigilantMike 17 points18 points  (2 children)

That wasn’t an unreasonable viewpoint back then. The vaccine itself was quick to make, but back in February of 2020 vaccines took years for trials and red tape. There was no operation warp speed, these things were expected to take time.

[–]406_realist 12 points13 points  (0 children)

You also never had a situation where the entire world is attempting to solve a single problem.

I try and be over optimistic, I had a feeling that IF they could indeed get a workable vaccine they’d get it done quick

[–]MC_Fap_Commander 3 points4 points  (0 children)

The unfortunate thing about those pessimists is that their voices are magnified in social media. This tends to affect policy and I fear that those who are "addicted to being miserable" will slow important actions like full school reopenings in the fall (which would be unfortunate if we succeed in getting a critical mass of people vaccinated).

[–]Sickofusernames95 140 points141 points  (51 children)

Since the shot gives 65% protection against the virus with only the risk of mild Covid for the rest, my question is this, can “mild” Covid result in long-hauler symptoms even if they are mild? And it seems like I’ve also heard that sometimes “mild” cases can still cause internal organ damage?

[–]tricorehat 50 points51 points  (0 children)

Unknown currently, long hauler symptoms are not well understood at current I know there are a few theories as to the underlying issues/mechanisms of post viral diseases or conditions but without understanding what is driving them it would be anyone's guess.

[–]defiantately 43 points44 points  (4 children)

This is just anecdotal, but I know a lot of people including myself who've had mild cases. I still occasionally have trouble breathing, and I have friends that have other symptoms like weakness, muscle pain, stomach issues, fatigue/brain fog, etc. The good news is after many months (we all had it last March), most of us have noticed improvement.

On the other hand, it seems like most clinically significant organ damage is related to hypoxia, so I think this is less likely to happen in mild cases. I was worried about lung damage due to my breathing issues but all my chest scans have been clear.

[–][deleted] 31 points32 points  (0 children)

While this is still a concern I think the important thing to remember is the difference not in what you experience but in what your body does.

Mild symptoms without a vaccine may be partially due to your body not fighting back or not fighting back as hard. This would mean the virus has more time to do more damage before your body figures out how to fight it.

Post vaccine your body knows how to fight the virus and when it sees it is far more likely to attack faster and keep it from spreading as far. You may still get mildly sick as your body fights back but the virus has less time and opportunity to spread and do damage.

Obviously none of this is a guarantee either way but I have to imagine a mild case post vaccine is far less likely to be able to spread in a way that can cause lasting damage.

[–]nakedrickjamesBoosted! ✨💉✅ 72 points73 points  (9 children)

We don't know. It's a big deal, not enough people are talking about it... but at least it IS currently being studied.
It's honestly my biggest hesitation behind the J&J vaccine. If the push for j&J is that "you might still get covid, but it'll basically be just a mild illness", that isn't so bad... unless that 'mild illness' lasts for months, years, or even the rest of your life.
The upshot is (I'm still waiting for someone else to crunch the actual numbers) it does appear that the efficacy is still on the way up at 28 days (which is when the 65% figure was calculated) and possibly getting close to pfizer / moderna once you get to 60 days post vaccination.
Another scenario is that no matter what vaccine you get, you'll end up with an mRNA booster to protect against variants. In which case, the end point is ultimately the same very high, very broad protection against infection.

[–]CorporalDingleberry 23 points24 points  (2 children)

That's exactly my hesitation with this one. While it's good that this prevents death and hospitalizations, I'd also want to know if it prevents long term chronic effects should one contract mild Covid.

I wonder if it will be possible for the lower risk people to get J&J for now and then later get Pfizer/Moderna once they're more readily available.

[–]chrisjozo 6 points7 points  (0 children)

Given it's relatively inexpensive I could see it being used by countries in the short term to give some protection until they get access to other vaccines. Some protection is better than nothing especially if you're not high on the list of countries getting other better vaccines.

[–]hiero_ 30 points31 points  (16 children)

Sorry to ask, this is a genuine question. If the vaccine from J&J is only 66% effective at preventing moderate to severe Covid, doesn't this mean an average of 1/3 people who take the vaccine and get infected will still have a moderate to severe bout of Covid? If I managed to get access to choose which vaccine I got to take, why would I want this vaccine over Pfizer or Moderna?

[–]Frnklfrwsr 40 points41 points  (0 children)

If you have a choice, the Pfizer or Moderna definitely seem to be the way to go.

But if the J&J is all that’s available then it’s still a great choice.

And it doesn’t mean 1/3rd of vaccinated people will have moderate/severe covid. It means of the people who got vaccinated, they are 66% less likely than non-vaccinated people to have moderate-severe disease.

Depending on your age group, the chances of covid being moderate to severe for you may be as low as 5% or lower. This just cuts that down even further.

[–]tasunderI'm fully vaccinated! 💉💪🩹 11 points12 points  (0 children)

It's efficacy against severe disease was 85% during the same interval, and that efficacy seems to increase over time. It seems like the shot reaches maximum efficacy somewhere around 50-60 days.

[–]KensinI'm fully vaccinated! 💉💪🩹 11 points12 points  (2 children)

The J&J shot might be a good match for young people who don't feel they're at much risk to begin with or anyone who is nervous about taking mRNA vaccines. I'll hold out for Pfizer or Moderna but I could see why some would be happy to take whatever they can get.

[–]datfngtrump 5 points6 points  (0 children)

I agree that the J&J shot is less than optimal with the 66% number being reported. That number near as I can disern has only been reported by Fox Radio. The CDC numbers have been as high as 85 - 92, I think I read that in this thread somewhere. Do not know if that is absolute but seem like there is some disinformation somewhere.

Edit: found the 66% number in an AP article, so it is not just Fox Radio, my bad.

[–][deleted] 4 points5 points  (1 child)

you got your numbers wrong. It's 72% overall in the USA, 66% effective overall in the world in preventing moderate to severe, but 85% effective in preventing severe disease and death. https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial

[–]IWRITE4LIFEBoosted! ✨💉✅ 13 points14 points  (2 children)

Does anybody have any info on the J&J trial regarding the two dose regimen? Are they still doing the trial and do we have any idea when it’d be completed?

I think it’d be cool to have a vaccine tested as being effective in both ways, a single dose where necessary and even better protection from a second dose

[–]Bv202 16 points17 points  (0 children)

I'm in the trial. It lasts until 2023. Results will be there when a certain amount of participants tested positive on COVID. So basically, the more virus circulation, the faster results could come in.

The study center I'm participating in is still vaccinating participants with their first shot until mid March. So these will get their second shot only by mid May.

I've heard first results are to be expected in or after summer.

[–]amox400 76 points77 points  (21 children)

Get ready for articles describing a socioeconomic and/or racial disparity in terms of who gets which vaccine. News outlets can try and make the two seem equal all they want but the reality is they aren’t and those who have the luxury of time and transportation will venture farther for an mRNA vaccine.

Now with pfizer having less strict temperature requirements allowing it to reach more rural areas and both them and moderna ramping up lets just send J&J out so we can start beating this thing globally.

[–]Hal9008 21 points22 points  (6 children)

Unfortunately, it does make sense to give this vaccine to groups that are less likely to come back for a second shot. I can see the homeless and people in county type jails as being prime candidates.

[–]Eng8D 13 points14 points  (6 children)

I'd take the J&J one now, but could I get an mRNA one later this summer when supplies are more available? What's the rules about this?

Primarily worried about death and long Covid.

[–]RubyRhod 16 points17 points  (5 children)

Get the first vaccine you are allowed to get. You can't compare efficacy rates considering all the +90% rates for the mRNA vaccines were done before the variants were prevalent.

[–]420blazeit69nubz 12 points13 points  (2 children)

Are the vaccines just luck of the draw for your state? I could see people wanting to take the Pfizer or Moderna instead of the J&J.

[–]blartcopy 32 points33 points  (0 children)

Great news to wake up to

[–]theboxturtle57Boosted! ✨💉✅ 21 points22 points  (2 children)

Inject this shit into my fucking veins (or pfizer or moderna idc)

[–]IntroSpeccy 14 points15 points  (1 child)

I think I prefer my muscle

[–]Dokter_Diskus 10 points11 points  (2 children)

Anyone know how this will affect vaccination rates?

[–]synthesis777 3 points4 points  (0 children)

Upset I had to scroll this far to see this question. I want to know this as well.

[–]Raiden091 53 points54 points  (1 child)

The game that previously existed no longer remains.

[–]hoky315 26 points27 points  (0 children)

coronavirus has left the chat

[–]questioneveything1 19 points20 points  (3 children)

Is that the baby powder cancer company?

[–]TheyreGoodDogsBrent 72 points73 points  (9 children)

I feel like too many people are going to focus on "72% effective against any infections" and not "100% effective against hospitalization and death".

Take the first shot you can get.

[–]Seshia 12 points13 points  (1 child)

Honest question here. Historically J&J has been linked to tons of medical malpractice. Because of this I am very nervous about the prospects of taking anything produced by them. Can you give me any reason why this product would be more trustworthy than things like their joint replacements/pain relievers?

[–]ilCannolo 51 points52 points  (23 children)

Incoming “game changer” comments!

[–]randomtrip10 14 points15 points  (1 child)

This is a changing game

[–]boooooooooo_cowboys 36 points37 points  (3 children)

It’ll be great for certain situations where cold storage is an issue or it’s unlikely that the person will come back for a second shot. But the whole “one shot” thing isn’t that much of a game changer when your two dose competitors are providing 10X as many doses in the same time frame.

[–]iskin 19 points20 points  (0 children)

10x as many doses now. In a month production will probably be closer or the same in volume. All resources are effectively doubled with this vaccine. That means fewer needle, syringe, and staff shortages. A lower barrier of entry for facilities to administer. This is now small feat.

[–]ElCaptain1 12 points13 points  (1 child)

This is a game changer. Can’t wait for America to run back to normal

[–]GiantTeddyGrahamBoosted! ✨💉✅ 37 points38 points  (11 children)

Get fucked Rona, normal summer here we come!

[–]ryanstrikesback 34 points35 points  (3 children)

Kissing strangers and spitting EVERYWHERE

[–]WesMack5 21 points22 points  (2 children)

Spit in my mouth pls

[–]Milkman127 5 points6 points  (0 children)

beautiful

[–]thecryptogandalfI'm fully vaccinated! 💉💪🩹 3 points4 points  (0 children)

That is good. If it is approved, one shot thing is a big thing. Double amount of vaccinated people compared to two shot vaccines.

[–]broteus7Boosted! ✨💉✅ 4 points5 points  (15 children)

Can someone explain what a moderate illness would be with covid? I understand severe would probably imply hospitalizations but weren't there some people who had it bad that didn't need to be hospitalized but were miserable for days?

[–][deleted] 4 points5 points  (0 children)

Some key facts about the J&J vaccine:

  • One dose instead of 2 doses (easier to vaccinate more people)

  • Can be stored at standard refrigeration temperatures (35.6 to 46.4 degrees Fahrenheit, much easier for logistics, transportation, and storage)

  • 85% effective in stopping severe Covid-19 disease

  • 72% effective against moderate Covid-19 disease in the US

  • Prevented 100% of hospitalizations and deaths in trials (HUGE news, this is the whole reason we have these restrictions)

  • 64% effective against moderate disease with the South Africa variant, 81% effective against severe disease (to reiterate, this is with the South Africa "EEK" variant and 64% is around the same as a good flu shot)

  • Reduces asymptomatic transmission (74% less likely to transmit virus to others after 71 days compared to placebo)

There is every reason to think this vaccine is a total game changer and will really help us get back to normal much quicker. I am beyond excited about it.

[–]intromission76 7 points8 points  (0 children)

So this one should be less risky for those with food allergies, yes?

[–][deleted] 12 points13 points  (1 child)

I hate shots , and would def prefer a single dose as I’m sure 99.99% of everyone else would lol

[–]FlyLeash 3 points4 points  (1 child)

Is this mrna vaccine or the other kind? (Just curious)

[–]RenegadeRabbit 4 points5 points  (0 children)

It's adenovirus-based