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Crossposted by20 hours ago

Deepmind’s AlphaFold Revealed the Structures of all the Proteins Known to Science, Expanding the AlphaFold DB by Over 200x

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Posted by20 hours ago

Deepmind’s AlphaFold Revealed the Structures of all the Proteins Known to Science, Expanding the AlphaFold DB by Over 200x

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level 1
· 19 hr. ago · edited 13 hr. ago

This is a tour de force for the technology, but this title is just wrong.

These aren't "revealed" structures, these are predicted. AF2 (and RoseTTAfold) are getting very good at predicting single domains, but lack accuracy for flexible proteins (IDPs arent going to adopt a single confirmation) and at predicting interdomain organization. This is a big step, but there is still a huge distance to go before anyone has "revealed" the structures of all proteins.

Edit: a word

71
level 2
· 18 hr. ago

Exactly, I was wondering how they could verify the predicted structure. I'm not sure how this can be useful for research if the structures are not experimentally validated.

11
level 2
· 3 hr. ago

No proteins occupy a single confirmation.

1
level 2
Op · 15 hr. ago
level 1
· 18 hr. ago

Antibodies say hi

6
level 2
· 2 hr. ago

I don't get it. What you mean?

1
level 1
· 11 hr. ago

Nowhere near close to all proteins. They have broad coverage of the UniProt database and 20 complete organisms. it has a long long way to go before all databases are combined parsed and folded

3

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