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Is it possible to create a desktop app with Python as back end, and HTML+CSS+JS as front end? Is it possible to create a desktop app with Python as back end, and HTML+CSS+JS as front end?

I'm currently developing a progeam that you can download on your PC with the purpose of obtaining data from a device and analyze them. I was wondering if Python can be used for back end while the other languages mentioned before as front end? If so, what frameworks are recommended? And if HTML, CSS and JS are better for web pages/sites/apps, what should I use to design said desktop app with Python?