Large earthquakes are always followed by aftershocks -- a series of smaller but still potentially damaging quakes produced as the ground readjusts. But how long does it take for the aftershocks to die out? A new study suggests some areas can experience aftershocks decades or even centuries after the original earthquake. From a report: In earthquake-prone areas it is hard to tell the difference between aftershocks and ordinary background seismicity. But recognising aftershocks is an important part of assessing a region's disaster risk. To understand how long aftershocks can persist, researchers turned to the stable continental interior of North America, where earthquakes are uncommon. Using statistical analysis they assessed the timing and clustering of quakes that followed three large magnitude 6.5 to 8 historical earthquakes: one near south-east Quebec in Canada in 1663; a trio of quakes around the Missouri-Kentucky border from 1811 to 1812; and an earthquake in Charleston in South Carolina in 1886. Their results, published in Journal of Geophysical Research: Solid Earth, suggest that the Quebec quake in 1663 has likely shaken itself out, but to their surprise nearly a third of modern quakes in the Missouri-Kentucky area were most likely to be aftershocks from the 1811-12 event, and about 16% of recent quakes in the Charleston region are probably aftershocks from the 1886 quake.

As if homesickness, wasting muscles, thinner bones, an elevated cancer risk, the inescapable company of overachievers and the prospect of death in the endless vacuum of space were not enough to contend with, male astronauts may return from deep space prone to erectile dysfunction, scientists say. From a report: In what is claimed to be the first study to assess the impact of galactic radiation and weightlessness on male sexual health, Nasa-funded researchers found that galactic cosmic rays, and to a lesser extent microgravity, can impair the function of erectile tissues, with effects lasting potentially for decades. Raising their concerns in a report on Wednesday, the US researchers said they had identified "a new health risk to consider with deep space exploration." They called for the sexual health of astronauts to be closely monitored on their return from future deep space missions, noting that certain antioxidants may help to counteract the ill-effects by blocking harmful biological processes.

"While the negative impacts of galactic cosmic radiation were long-lasting, functional improvements induced by acutely targeting the redox and nitric oxide pathways in the tissues suggest that the erectile dysfunction may be treatable," said Dr Justin La Favor, an expert in neurovascular dysfunction at Florida State University and a senior author on the study. The warning comes amid a renewed focus on deep space missions, with Nasa and other major space agencies preparing for long-term expeditions to the moon and more ambitious voyages to Mars. Nasa's Artemis programme aspires to send astronauts to the moon as early as next year, with crewed missions to Mars tentatively lined up for as early as 2040.

Rahul Rao reports via Space.com: On Nov. 14, NASA picked up a laser signal fired from an instrument that launched with the Psyche spacecraft, which is currently more than 10 million miles (16 million kilometers) from Earth and heading toward a mysterious metal asteroid. (The spacecraft is at more than 40 times the average distance of Earth's moon, and still voyaging afar.) The moment marked the first successful test of NASA's Deep Space Optical Communications (DSOC) system, a next-generation comms link that sends information not by radio waves but instead by laser light. It's part of a series of tests NASA is doing to speed up communications in deep space, on different missions. "Achieving first light is a tremendous achievement. The ground systems successfully detected the deep space laser photons from DSOC," Abi Biswas, the system's project technologist at NASA's Jet Propulsion Laboratory (JPL) in Southern California, said in an agency statement.

"And we were also able to send some data, meaning we were able to exchange 'bits of light' from and to deep space," Biswas added.

The U.S. Food and Drug Administration is reviewing a cutting-edge therapy called exa-cel that could potentially cure people of sickle cell disease, a painful and deadly disease with no universally successful treatment. "If approved, exa-cel, made by Boston-based Vertex Pharmaceuticals and the Swiss company CRISPR Therapeutics, would be the first FDA-approved treatment that uses genetic modification called CRISPR," reports CNN. From the report: CRISPR, or clustered regularly interspaced short palindromic repeats, is a technology researchers use to selectively modify DNA, the carrier of genetic information that the body uses to function and develop. [...] The new exa-cel treatment under FDA consideration can use the patient's own stem cells. Doctors would alter them with CRISPR to fix the genetic problems that cause sickle cell, and then the altered stem cells are given back to the patient in a one-time infusion.

In company studies, the treatment was considered safe, and it had a "highly positive benefit-risk for patients with severe sickle cell disease," Dr. Stephanie Krogmeier, vice president for global regulatory affairs with Vertex Pharmaceuticals Incorporated, told the panel. Thirty-nine of the 40 people tested with the treatment did not have a single vaso-occlusive crisis, which means the misshapen red blood cells block normal circulation and can cause moderate to severe pain. It's the top reason patients with sickle cell go to the emergency room or are hospitalized. Before the treatment, patients experienced about four of these painful crises a year, resulting in about two weeks in the hospital.

The FDA sought the independent panel's advice, in part, because this would be the first time the FDA would approve a treatment that uses CRISPR technology, but Dr. Fyodor Urnov, a professor in the Department of Molecular and Cell Biology at the University of California, Berkeley, reminded the committee CRISPR has been around for 30 years and, in that time, scientists have learned a lot about how to use it safely. "The technology is, in fact, ready for primetime," Urnov said. With this kind of genetic editing, scientists could inadvertently make a change to a patient's DNA that is off-target, and the therapy could harm the patient. [...] The FDA is expected to make an approval decision by December 8.

The use of environmentally damaging gases in air conditioners and refrigerators could become redundant if a new kind of heat pump lives up to its promise. A prototype, described in a study published last week in Science, uses electric fields and a special ceramic instead of alternately vaporizing a refrigerant fluid and condensing it with a compressor to warm or cool air. From a report: The technology combines a number of existing techniques and has "superlative performance," says Neil Mathur, a materials scientist at the University of Cambridge, UK. Emmanuel Defay, a materials scientist at the Luxembourg Institute of Science and Technology in Belvaux, and his collaborators built their experimental device out of a ceramic with a strong electrocaloric effect. Materials that exhibit this effect heat up when exposed to electric fields.

In an electrocaloric material, the atoms have an electric polarization -- a slight imbalance in their distribution of electrons, which gives these atoms a 'plus' and a 'minus' pole. When the material is left alone, the polarization of these atoms continuously swivels around in random directions. But when the material is exposed to an electric field, all the electrostatic poles suddenly align, like hair combed in one direction. This transition from disorder to order means that the electrons' entropy -- physicists' way of measuring disorder -- suddenly drops, Defay explains. But the laws of thermodynamics say that the total entropy of a system can never decline, so if it falls somewhere it must increase somewhere else. "The only possibility for the material to get rid of this extra mess is to pour it into the lattice" of its crystal structure, he says. That extra disorder means that the atoms themselves start vibrating faster, resulting in a rise in temperature.

"To celebrate my life, I've arranged to buy up others' medical debt and then destroy the debt," reads a posthumous tweet posted Tuesday after the death of 38-year-old Casey McIntyre.

The Washington Post explains... McIntyre, who served as publisher at Razorbill, an imprint of Penguin Random House, was diagnosed in 2019 and proceeded through treatment without taking on debt, [husband Andrew Rose] Gregory told The Washington Post. But many fellow cancer patients she met were in more precarious financial positions, Gregory added. "We were both so keenly aware that Casey had great health insurance through Penguin Random House," said Gregory, 41. "Casey had no medical debt...."

About nine months before McIntyre died, her husband came across a video online about members of a North Carolina church who purchased nearly $3.3 million of local residents' medical debt for $15,048 in a "debt jubilee," a historical reference to ancient stories about personal debts being canceled at regular intervals. The couple chose to make monthly donations to RIP Medical Debt, the same organization that partnered with the North Carolina churchgoers. The nonprofit organization aims to abolish medical debt "at pennies on the dollar," according to its website. For every $100 donated, the company relieves $10,000 of medical debt. As of Saturday, nearly $200,000 had been donated to RIP Medical Debt in McIntyre's memory, which would wipe out approximately $20 million of unpaid medical bills. [By Sunday afternoon it had risen to over $334,000...]

Allison Sesso, president and chief executive of RIP Medical Debt, said her organization found out about McIntyre's case after McIntyre's posthumous social media post went viral. Sesso said the pace of donations was record-setting for her charity. "What an incredible gesture to the world as you're exiting," Sesso told The Post. "This final act of generosity is blowing up. The amount that they're raising and the rate at which this has gone is not something that we're used to."
McIntyre's post on X has now received 65,400 likes — and 3,086 reposts.

"And no, it's not COBOL," jokes long-time Slashdot reader schwit1, sharing this report from ScienceAlert: A secret text has been discovered in Türkiye, scattered among tens of thousands of ancient clay tablets, which were written in the time of the Hittite Empire during the second millennium BCE. No one yet knows what the curious cuneiform script says, but it seems to be a long-lost language from more than 3,000 years ago.

Experts say the mysterious idiom is unlike any other ancient written language found in the Middle East, although it seems to share roots with other Anatolian-Indo-European languages. The sneaky scrawlings start at the end of a cultic ritual text written in Hittite — the oldest known Indo-European tongue — after an introduction that essentially translates to: "From now on, read in the language of the country of Kalasma"... Currently, there are no available photos of the newly discovered tablet with Kalamaic writings, as experts are still working out how to translate it. Schwemer and his colleagues hope to publish their results along with images of their discovery sometime next year.

A professor of religion at Columbia University writes, "I do not think human beings are the last stage in the evolutionary process." Whatever comes next will be neither simply organic nor simply machinic but will be the result of the increasingly symbiotic relationship between human beings and technology. Bound together as parasite/host, neither people nor technologies can exist apart from the other because they are constitutive prostheses of each other... So-called "artificial" intelligence is the latest extension of the emergent process through which life takes ever more diverse and complex forms.
The article lists "four trajectories that will be increasingly important for the symbiotic relationship between humans and machines."

- Writing about neuroprosthetics, the professor argues that "Increasing possibilities for symbiotic relations between computers and brains will lead to alternative forms of intelligence that are neither human nor machinic, but something in between."

- Then there's biobots. The article argues that with nanotechnology, "it will be increasingly difficult to distinguish the natural from the artificial."

But there's also an interesting discussion about synthetic biology. "Michael Levin and his colleagues at the Allen Discovery Center of Tufts University — biologists, computer scientists and engineers — have created "xenobots," which are "biological robots" that were produced from embryonic skin and muscle cells from an African clawed frog." As Levin and his colleagues wrote in 2020...

Here we show a scalable pipeline for creating functional novel lifeforms: AI methods automatically design diverse candidate lifeforms in silico to perform some desired function, and transferable designs are then created using a cell-based construction toolkit to realize living systems with predicted behavior. Although some steps in this pipeline still require manual intervention, complete automation in the future would pave the way for designing and deploying living systems for a wide range of functions.
And the article concludes with a discussion of organic-relational AI: While Levin uses computational technology to create and modify biological organisms, the German neurobiologist Peter Robin Hiesinger uses biological organisms to model computational processes by creating algorithms that evolve. This work involves nothing less than developing a new form of "artificial" intelligence... Non-anthropocentric AI would not be merely an imitation of human intelligence, but would be as different from our thinking as fungi, dog and crow cognition is from human cognition.

Machines are becoming more like people and people are becoming more like machines. Organism and machine? Organism or machine? Neither organism nor machine? Evolution is not over; something new, something different, perhaps infinitely and qualitatively different, is emerging.

Who would want the future to be the endless repetition of the past?

CNN reports SpaceX made a second attempt to successfully launch Starship, the most powerful rocket ever constructed. The uncrewed rocket took off just after 7 a.m. CT (8 a.m. ET). The rocket took off as intended, making it roughly 8 minutes into flight before SpaceX confirmed it had to intentionally explode the Starship spacecraft as it flew over the ocean...

This mission comes after months of back-and-forth with federal regulators as SpaceX has awaited a launch license. The company is also grappling with pushback from environmentalists...

After separating from the Super Heavy rocket booster, the Starship spacecraft soared to an altitude of approximately 93 miles (150 kilometers) before SpaceX lost contact, according to a statement issued by the company. For context, the U.S. government considers 50 miles (80 kilometers) above Earth's surface the edge of outer space...

SpaceX is OK with rockets exploding in the early stages of development. That's because the company uses a completely different approach to rocket design than, say, NASA. The space agency focuses on building one rocket and strenuously designing and testing it on the ground before its first flight — taking years but all but guaranteeing success on the first launch. SpaceX, however, rapidly builds new prototypes and is willing to test them to their breaking point because there's usually a spare nearby. During a drive by the company's facilities on Friday — four Starship spacecraft and at least two Super Heavy boosters could be seen from public roadways.
CNN reminds readers that "so far in 2023 alone, the Falcon 9 has launched more than 70 spaceflights...

"Elon Musk described Starship as the vehicle that underpins SpaceX's founding purpose: sending humans to Mars for the first time. NASA has its own plans for the rocket."

Doctors have long relied on a few key patient characteristics to assess risk of a heart attack or stroke, using a calculus that considers blood pressure, cholesterol, smoking and diabetes status, as well as demographics: age, sex and race. Now, the American Heart Association is taking race out of the equation. From a report: The overhaul of the widely used cardiac-risk algorithm is an acknowledgment that, unlike sex or age, race identification in and of itself is not a biological risk factor. The scientists who modified the algorithm decided from the start that race itself did not belong in clinical tools used to guide medical decision making, even though race might serve as a proxy for certain social circumstances, genetic predispositions or environmental exposures that raise the risk of cardiovascular disease.

The revision comes amid rising concern about health equity and racial bias within the U.S. health care system, and is part of a broader trend toward removing race from a variety of clinical algorithms. "We should not be using race to inform whether someone gets a treatment or doesn't get a treatment," said Dr. Sadiya Khan, a preventive cardiologist at Northwestern University Feinberg School of Medicine, who chaired the statement writing committee for the American Heart Association, or A.H.A. The statement was published on Friday [PDF] in the association's journal, Circulation. An online calculator using the new algorithm, called PREVENT, is still in development.

Davide Castelvecchi, writing for Nature: A Nature retraction last week has put to rest the latest claim of room-temperature superconductivity -- in which researchers said they had made a material that could conduct electricity without producing waste heat and without refrigeration. The retraction follows the downfall of an even more brazen claim about a supposed superconductor called LK-99, which went viral on social media earlier this year. Despite these high-profile setbacks, superconductivity researchers say the field is enjoying somewhat of a renaissance. "It's not a dying field -- on the contrary," says Lilia Boeri, a physicist who specializes in computational predictions at the Sapienza University of Rome. The progress is fuelled in part by the new capabilities of computer simulations to predict the existence and properties of undiscovered materials.

Much of the excitement is focused on 'super-hydrides -- hydrogen-rich materials that have shown superconductivity at ever-higher temperatures, as long as they are kept at high pressure. The subject of the retracted Nature paper was purported to be such a material, made of hydrogen, lutetium and nitrogen. But work in the past few years has unearthed several families of materials that could have revolutionary properties. "It really does look like we're on the hairy edge of being able to find a lot of new superconductors," says Paul Canfield, a physicist at Iowa State University in Ames and Ames National Laboratory.

Richard Speed reports via The Register: Scientists have revealed how data from a NASA telescope was secured thanks to creative thinking and a batch of Raspberry Pi computers. The telescope was the Super Pressure Balloon Imaging Telescope (SuperBIT), launched on April 16, 2023, from Wanaka Airport in New Zealand. The telescope was raised to approximately 33km in altitude by NASA's 532,000-cubic-meter (18.8-million-cubic-foot) balloon and, above circa 99.5 percent of the Earth's atmosphere, it spent over a month circumnavigating the globe and acquiring observations of astronomical objects. The plan had been for the payload to transmit its data to the ground using SpaceX's Starlink constellation and the US Tracking and Data Relay Satellite System (TDRSS). However, the Starlink connection went down soon after launch, on May 1, and the TDRSS connection became unstable on May 24. The boffins decided to attempt a landing on May 25 due to poor communications and concerns the balloon might be pulled away from further land crossings by weather.

The telescope itself was destroyed during the landing; it was dragged along the ground for 3km by a parachute that failed to detach, leaving a trail of debris in its wake. Miraculously, though, SuperBIT's solid-state drive was recovered intact. However, other than as a reference, its data was not needed thanks to the inclusion of Raspberry Pi-powered hardware in the form of four Data Recovery System (DRS) capsules. Each capsule included a Raspberry Pi 3B and 5TB of solid-state storage. A parachute, a Global Navigation Satellite System (GNSS) receiver, and an Iridium short-burst data transceiver were also included so the hardware could report its location to the recovery team. The capsules were connected to the main payload via Ethernet, and 24V DC was also available.

The plan had been to release the first DRS capsule on day 40, and then another every 20 days after that, whenever SuperBIT passed over land. However, when it became clear that SuperBIT would have to come down on May 25, it was decided to drop two DRS capsules over Argentina's Santa Cruz Province. Both of the DRS capsules released were recovered from their reported locations -- a curious cougar apparently nosed around one of them without causing damage -- and the data was fully intact. Of the unreleased DRS capsules, one failed for unknown reasons at launch -- the team speculated that perhaps a cable came loose -- but the other also contained an intact data set.

Britain's drugs regulator has approved a groundbreaking treatment for two painful and debilitating lifelong blood disorders, which works by "editing" the gene that causes them. From a report: The Medicines and Healthcare products Regulatory Agency (MHRA) has given the green light for Casgevy to be used to treat sickle cell disease and beta thalassemia. It is the first medicine licensed anywhere that works by deploying gene editing that uses the "genetic scissors," known as CRISPR, for which its inventors won the Nobel prize for chemistry.

Casgevy's developers hope the pioneering treatment could banish the pain, infections and anaemia sickle cell disease brings and the severe anaemia experienced by those with beta thalassemia. About 15,000 people in the UK, almost all of African or Caribbean heritage, have sickle cell disease. About 1,000 -- mainly of Mediterranean, south Asian, south-east Asian and Middle Eastern background -- have beta thalassemia and need regular blood transfusions to treat their anaemia. Experts in the illnesses hope Casgevy may be a cure, making it no longer necessary for people with the conditions to have a bone marrow transplant. Until now this has been the only treatment available, even though the body can reject the donor marrow. The Sickle Cell Society welcomed the MHRA's decision as a "historic moment for the sickle cell community" which "offers [them] newfound hope and optimism."

The FAA has cleared SpaceX to launch its second spaceflight attempt of its Starship rocket. CNBC reports: SpaceX posted on the social media platform X shortly after the greenlight that it was "targeting Friday, November 17 for Starship's second flight test." A two-hour launch window will begin at 8 a.m. ET. SpaceX plans to livestream the Starship launch, with a webcast beginning about 30 minutes before lift off. Starship first launched in April, achieving flight for a few minutes before exploding mid-air, severely damaging the ground infrastructure and raising environmental concerns. The FAA in coordination with the U.S. Fish and Wildlife Service launched a safety review prior to issuing a new flight license for the second attempt.

FWS determined that the rocket launch and subsequent damage to the pad infrastructure had no long-term negative effects on the surrounding ecology, according to an agency report released Wednesday. Still, SpaceX will help mitigate damage to the area by reducing sound waves and vibrations, assisting in fire suppression, and providing launch pad protection, the agency said. As a result, "the FAA determined SpaceX met all safety, environmental, policy and financial responsibility requirements," the agency said in a statement Wednesday.

An anonymous reader quotes a report from NBC News: A prolonged decline in male fertility in the form of sperm concentrations appears to be connected to the use of pesticides, according to a study published Wednesday. Researchers compiled, rated and reviewed the results of 25 studies of certain pesticides and male fertility and found that men who had been exposed to certain classes of pesticides had significantly lower sperm concentrations. The study, published Wednesday in Environmental Health Perspectives, included data from more than 1,700 men and spanned several decades. "No matter how we looked at the analysis and results, we saw a persistent association between increasing levels of insecticide and decreases in sperm concentration," said study author Melissa Perry, who is an environmental epidemiologist and the dean of the College of Public Health at George Mason University. "I would hope this study would get the attention of regulators seeking to make decisions to keep the public safe from inadvertent, unplanned impacts of insecticides." [...]

Scientists have long suspected changes to the environment could be contributing, and they've been probing the role of pesticides for decades in studies of animals and in human epidemiology research. The new analysis focuses on two groups of chemicals -- organophosphates and some carbamates -- that are commonly used in insecticides. The researchers looked at data collected from groups of people with exposures to pesticides and others who were not. Most, but not all, of the research centered on exposures in the workplace. The researchers controlled for outside factors that could contribute to lower sperm counts like smoking and age. Perry said researchers aren't sure how pesticides are affecting sperm concentrations and more research will be needed.

It's likely that pesticides are one of many environmental factors that could be contributing to a decline in sperm concentrations. The trend of sperm concentration declines has been widely observed in studies around the world, but it's a complicated topic and some scientists still have reservations. Sperm are notoriously difficult to count and the technology to do so has changed over the years. There are many confounding factors that can affect male fertility, including age, obesity and opioid use, to name a few. Sperm concentrations are one important data point to consider, but other factors -- like how sperm are shaped and how they swim -- are also critical to male fertility. Perry said she hopes agencies like the Environmental Protection Agency begin to factor the impact of chemicals and pesticides on reproductive health in their assessments. "Given the body of evidence and these consistent findings, it's time to proactively reduce these insecticide exposures for men wanting to have families," Perry said.