I believe that all graphic designers have a few secret tricks in Adobe... you know, those little keystrokes, obscure tools, and special sequences that make you cackle to yourself when you pull them out because you are so damn clever.

Here's mine: You have a many layers in photoshop and you just want to try an effect/manipulation on the whole thing. Instead of flattening image, or trying to merge layers in a way that preserves effects, use the keystroke Shift+opt+cmd+e and it will make a flat copy of all the visible layers on its own layer at top while keeping all working layers preserved beneath.

EDIT: Thought of another one. I use shift + arrow keys to do larger nudges. This works both for moving objects across the page in indd or ai, or for making bigger jumps when selecting type sizing in the character palette. Basically hold shift with arrow keys to go in bigger chunks.

What's you favorite trick? Let's unleash some secret weapons.