This is going to be very vague but it's been my white whale for years and finding this subreddit jogged it again. Some things I say might be false so if something fits what I'm saying even a little bit I want to hear it. Sometimes I think I dreamed this entire thing.

Platform(s): PC

Genre: I remember nothing about the gameplay but I think it might have been an art game

Estimated year of release: Going by my age, I'm certain it was 90s

Graphics/art style: A pixelly cartoon style (not pixel art, but the jagged edges you see on old low-res games). Very simple, bright colors. I think you were in a house and there was a boy and a girl. I remember the aesthetic reminded me of old Nickelodeon/Nick Jr. but I don't think it's a Nick game.

Notable characters: My strongest memory of this game is a muppet-looking orange girl with pigtails. I'm pretty sure there was a boy character too but I don't remember him at all. I'm attaching a drawing of how I remember her looking (with the simple jagged pixel drawing style I remember). I remember specifically the flat circular part of her pigtails facing the camera, and the oval nose. She was one of the main characters who talked to you.