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Slate Star Codex: In a Mad World, All Blogging is Psychiatry Blogging

r/slatestarcodex

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Posted by
or sth idk
21 hours ago

limply balancing mile-deep cocktail glasses and clamoring for laughable Thielbucks on the cramped terraces of Berkely,
who invite you to the luring Bay, promising to pay for your entire being while elegantly concealing the scarlet light evaporating from their tearducts and nostrils,
who down 3¾ bottles of Huel™ and sprint to their next fellowship or retreat or meetup or workshop, in the pore-showingly lit hallways with whiteboards and whiteboards and whiteboards and whiteboards,
who want to crown random nerds with aureal sigmas fished from the manifold crevaces of self-denying deities,
who write epics of institutionalized autists bent on terraforming these overpopulated hypothetical hells,
pointing out dynamic inconsistency in the comments and melting hectoton steel-marbles around civilizational recipes,
who improve their aim hurling yeeting philosophical tomes at unsuspecting passerbys and ascend urban lampposts to loudly deduce their mechanical liturgies,
cascades! cycles! insights!
who cut down oaks and poppies in the parks to make oil and space for those ones yet to come and who hunker down in fortified coalmines in Montana and the Ruhrgebiet, propelled into the rock by an Ordite reactor, a Bostromite dynamo,
who exitedly pour & plaster tabulated exponents into webscripted canisters just below the teal-tinted ceiling,
hating one-sidedness and bureaucrats alike,
who can name the 11 AI forecasting organisations and the 4 factors of successful nonprofits and the 7 noble ways of becoming more agentic and might even find Rwanda on a map not made in Silicon Valley,
contemplating hemispherectomies to purify their nascent idealism on the verge of a hope-ash London dawn,
who catch a feral heart in the garden behind the A100 rack and save it into a transparent domicile, injecting it with 17000 volts to illuminate all the last battery cages equally,
who empty out their pockets with uncountable glaring utilons onto innocent climate activists, promising to make them happy neutron stars one day,
microscopically examining the abyssal monstrosities their oracles conjure up out of the lurching empty chaos,
recursion! magic!
who fever towards silver tendrils bashing open their skulls and eating up their brains and imaginations, losslessly swallowed into that ellipsoid strange matter gut pulsing out there between the holes

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Posted by7 hours ago
Perspective: Focused-Ultrasound Guided Neuropeptide Delivery as a Novel Therapeutic Approach in Psychiatry

Abstract

Although drugs are a critical component of mental healthcare, most have modest benefits and significant side effects. One way to develop a superior intervention would be to administer drugs with the spatial and temporal precision that better replicates natural diversity within neurotransmitter systems. A technology called focused-ultrasound (FU) may be able to safely and transiently disrupt the blood-brain barrier with spatial precision, permitting the site-specific delivery of molecules that do not conventionally cross the blood-brain barrier. If this method is proven to be safe and effective in larger human trials, it may trigger a paradigm shift in biopsychology research where the level of precision with which neurotransmitter systems can be influenced is massively increased. In this article, we use the example of oxytocin in the treatment of Autism. We propose that intranasal administration is not highly effective because it leads to oxytocin’s wide dispersion throughout the brain, failing to specifically stimulate oxytocin’s prosocial effects in specific regions. Consequently, we hypothesize that site-specific delivery of oxytocin, particularly in brain regions such as the Nucleus Accumbens and Ventral Tegmental Area, would lead to more consistent benefits.

--

Seeds of Science is a journal (funded through Scott Alexander's ACX grants program) that publishes speculative or non-traditional articles on scientific topics. Peer review is conducted through community-based voting and commenting by a diverse network of reviewers (or "gardeners" as we call them); top comments are published after the main text of the manuscript. 

We have just sent out an article for review that may be of interest to some in the SSC community, so I wanted to see if anyone - particularly those with a background in neuroscience - would be interested in joining us as a gardener providing feedback on the article. It is free to join and anyone is welcome (we currently have gardeners from all levels of academia and outside of it). Participation is entirely voluntary - we send you submitted articles and you can choose to vote/comment or abstain without notification (so it's no worries if you don't plan on reviewing very often but just want to take a look here and there at the articles people are submitting). 

To register, you can fill out this google form. From there, it's pretty self-explanatory - I will add you to the mailing list and send you an email that includes the manuscript, our publication criteria, and a simple review form for recording votes/comments. If you would like to just take a look at this article without being added to the mailing list, then just reach out (info@theseedsofscience.org) and say so. 

Happy to answer any questions about the journal through email or in the comments below.

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About Community

Slate Star Codex was a blog by Scott Alexander about human cognition, politics, and medicine. He now blogs at Astral Codex Ten: https://astralcodexten.substack.com/
Created Feb 26, 2014

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