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Surface Finish of WFI (or high purity water) tanks and Piping by andy_oohhh in ChemicalEngineering

[–]ijv182 1 point2 points  (0 children)

Unfortunately I don’t really know if the mechanisms that bacteria use to start catching onto surfaces but if I had to guess, it’s not so much that a whole microbe gets in there but rather the crevice is sufficient for some of the microbes perimeter to catch on and that snow balls into more and more bugs sticking and multiplying. Or alternatively it’s possible that cell debris, smaller than a whole microbe, would nest in a crevice and serve as a nucleation site. This is purely speculation though, in my day to day job, I just follow what is industry standard. Maybe someone who’s more familiar with the BPE origins can fill us in.

Practically, I imagine that some manufacturers struggled with bio burden and found that smoother surface finishes mitigated the risk and that became industry standard. The pharm and biotech industries are slow to pick up on changes that could be seen as riskier. To your point, even if an sf6 finish was shown in a lab to be no more risky than an sf5, odds are companies would be extremely hesitant to relax that standard because it would be moving away from what’s been proven to be low risk.

Surface Finish of WFI (or high purity water) tanks and Piping by andy_oohhh in ChemicalEngineering

[–]ijv182 9 points10 points  (0 children)

Rough finishes (even if imperceptible to our eyes) will provide cavities and crevices for microbes to first grab onto and start growing in place instead of flushing to drain.

Think of how paint won’t stick well to a surface unless you sand it first.

Similarly, those tiny crevices are additional cracks that need to be cleaned. For that reason electropolish is preferred. Mechanical polishing can get to similar surface finishes but again, the mechanical action leaves tons of imperfections for bugs to latch onto.

ISPE guides will have better info but from experience SF5 is what I’ve seen for anything process contact in high purity. You should also familiarize yourself with ASME BPE for similar caveats for high purity piping design

Piping Design Learning Materials - Upcoming Interview by poljohn in ChemicalEngineering

[–]ijv182 0 points1 point  (0 children)

Idk if it’s an industry standard but Revit is the modeling software I’ve seen used most. Maybe you can also look for sample pipe and insulation specs online. This will give you insight to component and construction standards like branch sizing charts. If this position is for pharma you’ll also want to start looking at ASME BPE for nuances to sanitary piping which is a whole different animal to mechanical piping design.

iMac fusion drive failing, unclear about repair options by ijv182 in mac

[–]ijv182[S] 0 points1 point  (0 children)

That’s a good point! I think as a stopgap I’ll be picking up a SATA ssd and using a spare usb3 enclosure I have laying around. To be honest the speed of the fusion drive has never been an issue for me, I just need it to stop crashing on me while I’m listening to class lectures 😩

iMac fusion drive failing, unclear about repair options by ijv182 in mac

[–]ijv182[S] 0 points1 point  (0 children)

It’s a 2017 27”, my bad I didn’t know the size differed, I assumed they were all some small form factor drive.

Mine is a 1Tb so sounds like that won’t even be big enough to install the OS, although maybe large enough for a native bootcamp? Who knows lol

I'm thinking of giving up on working as a chemical engineer by Impossible-Fox-5773 in ChemicalEngineering

[–]ijv182 5 points6 points  (0 children)

Dude you’re only 6 months into your current position, I think you’re being too hard on yourself. It’s normal to feel incompetent; your industry is new to you and you’re still relatively fresh out of school. I think what’s setting in is how little you actually know about your industry or role and this is normal. What’s important is how you set yourself up to dig yourself out of that knowledge/experience deficit.

It’s good that you’re asking lots of questions, sucks that your SMEs aren’t that welcoming but this might be an opportunity to learn how to adjust your approach when dealing with difficult people. You didn’t mention how often you ask questions or how you structure your questions but when working with folks that aren’t too receptive, I’ve found it’s best to compile lists of questions to ask in a single session as opposed to pinging throughout the day. I’ve also found it’s best to lead discussions with recapping what I’ve done to find the answer myself.

Regarding your manager approaching you about expectations; I’ve got two potential hot takes.

1) no one hires an entry level engineer expecting a lead or SME level of experience. If your manager doesn’t talk to you about your expectations then it might still be good for you to ask about expectations and ask often so you know what you need to be working towards.

2) getting feedback, even if negative, this isn’t exactly the worst thing to hear when your at this stage of your career assuming a) your job actually cares about your development and b) you take that feedback constructively and fix it asap. Again you’re still discovering what you don’t know from a technical and possibly interpersonal perspective. You want to know what are areas you need to focus on while it’s okay for you to make mistakes as opposed to carrying bad habits to future positions, where those habits might be unacceptable from a mid-level engineer.

Is your mass transfer course of any help for a Chemical Engineering grad? by Consistent_Peace14 in ChemicalEngineering

[–]ijv182 1 point2 points  (0 children)

Dang and all I got was a chapter at the end of my heat transfer course 😵‍💫

Biopharma -> refining by tomatotornado420 in ChemicalEngineering

[–]ijv182 0 points1 point  (0 children)

Sounds like you’re in operations? Like day to day manufacturing?

I haven’t worked client side but actual manufacturing sounds not very exciting. Idk if you’re in the US (though I imagine this applies everywhere) but given how regulated the industry is, there isn’t much room to get creative in terms of finding improvements when things go wrong (which is where I’d imagine process engineering should be fun).

I work in a design setting in biotech so I’ve worked with different client groups during different phases of a projects lifecycle, I think there are other operational groups you might find more interesting.

Tech transfer/ms&t if you’re interested in process development/process design. Like I said, you really can’t make changes to a process once it’s licensed so here’s where the actual experimentation and tweaking of process parameters happens. Lots of characterization studies and the like.

Engineering services; some larger corps have dedicated engineering groups to make sure that their facilities are aligned from an SOP/design philosophy perspective. This is more akin to what I do on the day to day but representing the client directly. This route/design in general is pretty neat as here’s where optimization from an equipment perspective can happen. There’s also opportunities to see a facility start up/do troubleshooting and automation tubing here if you’re on a project through construction.

If you knew all this than nvm, but just my $0.02 on where interesting work for biotech process engineers actually is lol

Biopharma -> refining by tomatotornado420 in ChemicalEngineering

[–]ijv182 0 points1 point  (0 children)

Are you client side or working for a validation/C&Q firm?

Replaced blower filter and noticed rusty stains for the first time. Wait to see what happens or call a tech? by ijv182 in hvacadvice

[–]ijv182[S] 1 point2 points  (0 children)

Im guessing condensate is dropping into the filter? Though nothings been changed to the condensate line so I’m pretty confused by this sight.

The filter was also bowing out in the direction of air flow. Again guessing this is caused by moisture on the filter increasing resistance?

Anyway I’m not sure if this is a wait and see issue or a sign of impending doom

Need advice on must-have cleaning devices for pet owners by Sensualbuffalo39 in homeimprovementideas

[–]ijv182 11 points12 points  (0 children)

Regarding vacuums in general, you want to make sure you get one with a sealed HEPA filter to help with allergens. I highly recommend a good robot vac too that can help with keeping shedding fur down to a minimum between regular vacuuming

2022 British Grand Prix - Race Discussion by F1-Bot in formula1

[–]ijv182 0 points1 point  (0 children)

Latifi is gonna out score max today, calling it now

2022 British Grand Prix - Race Discussion by F1-Bot in formula1

[–]ijv182 5 points6 points  (0 children)

Is it just me or did Zhou’s halo look crushed?

Obi-Wan Kenobi - Episode 6 - Discussion Thread! by titleproblems in StarWars

[–]ijv182 1 point2 points  (0 children)

I’m glad I’m not the only one who thought this. At the start of the series it seemed he was completely prepared (emotionally at least) kill him. Even at the start of the confrontation; “I’ll do what I must” 😤 kinda missed the objective there Ben!

Question: What do you use all that lab equipment for? by bit_banger_ in homelab

[–]ijv182 1 point2 points  (0 children)

https://www.samba.org/samba/docs/current/man-html/vfs_fruit.8.html

Here’s the reference I used. I can get specifics from my conf file after work but iirc I just set the vfs objects parameter in the global section and the fruit:time machine parameter in the specific share section