Generic top-level domain

Generic top-level domains (gTLDs) are one of the categories of top-level domains (TLDs) maintained by the Internet Assigned Numbers Authority (IANA) for use in the Domain Name System of the Internet. A top-level domain is the last label of every fully qualified domain name. They are called generic for historic reasons; initially, they were contrasted with country-specific TLDs in RFC 920.

The core group of generic top-level domains consists of the com, info, net, and org domains. In addition, the domains biz, name, and pro are also considered generic; however, these are designated as restricted, because registrations within them require proof of eligibility within the guidelines set for each.

Historically, the group of generic top-level domains included domains, created in the early development of the domain name system, that are now sponsored by designated agencies or organizations and are restricted to specific types of registrants. Thus, domains edu, gov, int, and mil are now considered sponsored top-level domains, much like the themed top-level domains (e.g., jobs). The entire group of domains that do not have a geographic or country designation (see country-code top-level domain) is still often referred to by the term generic TLDs.

Shut Out (album)

Shut Out is the debut album by American actor, singer and songwriter Paul Jabara.

The album which was released on the Casablanca Records label in 1977 includes the singles "Shut Out" (a duet with Donna Summer), "Dance" and "Slow Dancing". The original LP was pressed on red vinyl.

Shut Out has yet to be re-released on CD.

Track listing

Dance (Disco Heat)

"Dance (Disco Heat)" is the title of a 1978 single by American disco singer Sylvester James, who performed using just his first name, Sylvester. The song became Sylvester's first Top 40 hit in the US, where it peaked at #19 on the Billboard Hot 100 chart in the fall of 1978; it also reached #29 on the UK Singles Chart. The song appears on his 1978 album, Step II.

A 12" single was released in 1978, with "Dance (Disco Heat)" as the A-side and "You Make Me Feel (Mighty Real)" as the B-side, and these two extended dance mixes proved to be very popular in the dance clubs at the time. The two songs held down the top spot on the Billboard Dance/Disco chart for six weeks in August and September of that year and helped to establish Sylvester's career as a noted disco and dance music performer, both in the U.S. and abroad.

References

External links

Lapping

Lapping is a machining process, in which two surfaces are rubbed together with an abrasive between them, by hand movement or using a machine.

This can take two forms. The first type of lapping (traditionally called grinding), involves rubbing a brittle material such as glass against a surface such as iron or glass itself (also known as the "lap" or grinding tool) with an abrasive such as aluminum oxide, jeweller's rouge, optician's rouge, emery, silicon carbide, diamond, etc., between them. This produces microscopic conchoidal fractures as the abrasive rolls about between the two surfaces and removes material from both.

The other form of lapping involves a softer material such as pitch or a ceramic for the lap, which is "charged" with the abrasive. The lap is then used to cut a harder material — the workpiece. The abrasive embeds within the softer material, which holds it and permits it to score across and cut the harder material. Taken to a finer limit, this will produce a polished surface such as with a polishing cloth on an automobile, or a polishing cloth or polishing pitch upon glass or steel.

Stathmin

Stathmin 1/oncoprotein 18, also known as STMN1, is a highly conserved 17 kDa protein. Its function as an important regulatory protein of microtubule dynamics has been well-characterized. Eukaryotic microtubules are one of three major components of the cell’s cytoskeleton. They are highly dynamic structures that continuously alternate between assembly and disassembly. Stathmin performs an important function in regulating rapid microtubule remodeling of the cytoskeleton in response to the cell’s needs. Microtubules are cylindrical polymers of α,β-tubulin. Their assembly is in part determined by the concentration of free tubulin in the cytoplasm.

At low concentrations of free tubulin, the growth rate at the microtubule ends is slowed and results in an increased rate of depolymerization (disassembly).

Function

Stathmin interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex. One mole of stathmin binds to two moles of tubulin dimers through the stathmin-like domain (SLD). When stathmin sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable. Without tubulin polymerization, there is no microtubule assembly. Stathmin also promotes microtubule disassembly by acting directly on the microtubule ends.