Please tell us which country and city you'd like to see the weather in.
Bace
Bace is a village in the municipality of Prokuplje, Serbia. According to the 2002 census, the village has a population of 284 people.
References
Coordinates: 43°13′13″N 21°20′43″E / 43.22028°N 21.34528°E / 43.22028; 21.34528
Beta-secretase 1
Beta-secretase 1 (BACE1), also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1, membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene.
BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer.
Role in Alzheimer's disease
Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the amyloid precursor protein (APP). Extracellular cleavage of APP by BACE1 creates a soluble extracellular fragment and a cell membrane-bound fragment referred to as C99. Cleavage of C99 within its transmembrane domain by γ-secretase releases the intracellular domain of APP and produces amyloid-β. Since alpha-secretase cleaves APP closer to the cell membrane than BACE1 does, it removes a fragment of the amyloid-β peptide. Initial cleavage of APP by alpha-secretase rather than BACE1 prevents eventual generation of amyloid-β.
Beta-secretase 2
Beta-secretase 2 is an enzyme that in humans is encoded by the BACE2 gene.
BACE2 is a close homolog of BACE1, a protease known to be an important enzyme involved in the cellular pathways that some believe lead to Alzheimer's disease. The physiological function and role of BACE2 in Alzheimer's disease is unknown.
Function
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. It has been reported that BACE2 is the main protease that mediates the release of the amyloidogenic ectodomain of Pmel17 in melanocytes.
Radio Stations - Bace
SEARCH FOR RADIOS
Bace
ALBUMS
- Unravelled released: 2006
Boss Playa
Boss Playa .. Boss Playa ..
Big Snoop Dogg .. is a Boss Playa
This is the archbishop .. Don Magic Juan
Skin and game, cheah
Many people don't be knowin' about this pimp game (pimp game)
But I'm sure they wanna know about this pimp game (pimp game)
And to me you know it aint no motherfuckin' thang
To give it to you plain and simple, cause you know its played
Holla at 'em Doggy Dogg, go and do that thang (go ahead)
Ok son, I'll tell ya like my nigga "Pootie Tang"
I got that bounce, to make her booty swang
That little cutie thang, 'fraid she's a beauty bang
Rollin' with a player cause thats what he was
And dedicated to his paper, Jesus
On his bitches (hard as feeds uck)
And if them law boys pull him over he won't freeze up
He got the heata-fa-heata and the keysa
With a pocket full of big faced Visas
They say its cheaper to keep her, now baby ease up
Kick back and blaze some of these trees up
Now sit your ass in the treesa
And do me a favor and turn the music up
Should I slap her, or should I freak her
I'll take the stronga, you can have the weaka
Speak when spoken to, yeah I broke a few
And by the way I was hoping you
Had a freak for me and a freak for you
I make 'em do for us
The thang you been wantin' her to do for months
This is the Chairman of the Board ..
The archbishop Don Magic Juan ..
Big Snoop Dogg .. is a boss playa
As a matter a fact
I was there when he was crowned 'Boss Playa', cheah
I had three on my right arm and four on my left
Lime green and gold, we was sharp to death
Had to catch my breath, watch my step
Playin' this game, you can holla at the ref
And call a timeout, before you put your dime out
Stop, pause, rewind before you put your rhyme out
And go to the "Wizard of Oz"
And tell 'em that your tryin' to get yourself a brand new heart
A brand new start
Cause you realized that you hadn't played your part
And that was smart
It's like a art the way I articulate
And break these bitches from state to state
See, I've been the flyest since I came out the gate
I ain't ask for it homie I just shake and bake
I won't fake to make you buy my tape
I say a prayer to the Lord just to keep my faith
Fuck straight
Will you steal for me? (Yes I will)
Will you kill for me? (Yes I will)
Would you lie to me? (Never)
Would you die for me? (Whenever)
Will you steal for me? (Yes I will)
Will you kill for me? (Yes I will)
Would you lie to me? (Never)
Would you die for me? (Whenever, whenever)
Big Snoop Dogg, lets you know ..
That this game ain't for no lame ..
If you got heart, you can play this game
But if your heart ain't right
We got a remedy for that, too
You gotta go see the wizard .. to get you some heart
And the archbishop Don Magic Juan is the Wizard
That's got the game .. for them lame
Boss Playa .. Boss Playa .. that's what this gang is all about
Boss Playa
Gangsta, Gangsta, where you been?
Round the corner messin' with brothanem
Youngsta, Youngsta, you at it again?
Poppin' gats for the fuck of it, when you know you got ends
I don't think that you should be in the streets like that
You know you the fashion type of cat
Always in them stores, with major whores
Doin' things, bling bling
West Coast runnin', lovin', hustlin' smokin', always chokin' in the green
With the sticky in yo hand fo sho
Everybody round ya cause they know you got mo'
Wet Cristal, you like to get wild
You like to dip in yo sexy shit
Rollin' through them streets, poppin' CPT