H2 antagonists, also called H2 blockers, are a class of medications that block the action of histamine at the histamine H2 receptors of the parietal cells in the stomach. This decreases the production of stomach acid. H2 antagonists can be used in the treatment of dyspepsia, but have been surpassed by the more effectiveproton pump inhibitors for that indication. They are also used to treat peptic ulcer disease and gastroesophageal reflux disease.
H2 antagonists are a type of antihistamine, although in common use the term "antihistamine" is often reserved for H1 antagonists. Like the H1 antagonists, some H2 antagonists function as inverse agonists rather than receptor antagonists, due to the constitutive activity of these receptors.
The prototypical H2 antagonist, called cimetidine, was developed by Sir James Black at Smith, Kline & French (now GlaxoSmithKline) in the mid-to-late 1960s. It was first marketed in 1976 and sold under the trade name Tagamet, which would become the first blockbuster drug. The use of quantitative structure-activity relationships (QSAR) led to the development of other agents—starting with ranitidine, first sold as Zantac—which has fewer adverse effects and drug interactions and is more potent.
[Kanye West]
Yeah, uh
(Sun in the sky)
(You know how I feel)
Me and the RZA connect
(Breeze driftin’ on by)
Yeah, me and the RZA connect
(Breeze driftin’ on by)
(It’s a new life for me)
(For me, for me)
(Oooh, oooh)
(And I’m feelin’ good)
And I’ll never let my son have an ego
He’ll be nice to everyone, wherever we go
I mean, I might even make ‘em be Republican
So everybody know he love white people
And I’ll never let ‘em leave his college girlfriend
And get caught up with the groupies in the whirlwind
And I’ll never let ‘em ever hit the telethon
I mean even if people dyin’ and the world ends
See, I just want ‘im to have an easy life, not like Yeezy life
Just want ‘im to be someone people like
Don’t want ‘im to be hated, all the time judged
Don’t be like your daddy that would never budge
And I’ll never let ‘im ever hit a strip club
I learned the hard way, that ain’t the place to get love
And I’ll never let his mom move to L.A.
Knowin’ she couldn’t take the pressure, now we all pray
(Sun in the sky)
(You know how I feel)
(Breeze driftin’ on by)
(Breeze driftin’ on by)
(It’s a new life for me)
Me and the RZA connect
(For me, for me)
Me and the RZA connect (Oooh, oooh)
(And I’m feelin’ good)
[Jay-Z]
Sorry junior, I already ruined ya
‘Cause you ain’t even alive, paparazzi pursuin’ ya
Sins of a father make yo’ life ten times harder
I just wanna take ya to a barber
Bondin’ on charters, all the shit that I never did
Teach ya good values, so you cherish it
Took me 26 years to find my path
My only job is cuttin’ the time in half
So at 13 we’ll have our first drink together
Black bar mitzvahs, mazel tov, mogul talk
Look a man dead in his eyes
So he know you talk truth when you speak it, give your word, keep it
And if the day comes I only see him on the weekend
I just pray we was in love on the night that we conceived him
Promise to never leave him even if his mama tweakin’
Cause my dad left me and I promise never repeat him
Never repeat him, never repeat him
(Sun in the sky)
(You know how I feel)
(Breeze driftin’ on by)
(Breeze driftin’ on by)
(It’s a new life for me)
(For me, for me)
(Oooh, oooh)
(And I’m feelin’ good)
(Sun in the sky, you know how I feel)
(Breeze driftin’ on by, you know how I feel)
(Breeze driftin’ on by, you know how I feel)
(It’s a new life for me)
(It’s a new dawn, it’s a new day)
(It’s a new life for me)
(Oooh, oooh)
(And I’m feelin’…)