The .45 ACP (11.43×23mm) (Automatic Colt Pistol), also known as the .45 Auto by C.I.P. or 45 Auto by SAAMI, is a cartridge designed by John Browning in 1904, for use in his prototype Colt semi-automatic .45 pistol and eventually the M1911 pistol adopted by the United States Army in 1911.
The U.S. Cavalry had been buying and testing various handguns in the late 1890s and early 20th century. The .45 Colt Single Action Army (SAA) had largely been replaced, even by some double-action versions of the same. The Army had fielded some double-action revolvers in .38 Long Colt. They determined the .38 caliber round was significantly less effective against determined opponents, such as the warriors encountered in the Moro Rebellion of the Philippine–American War, than the .45 Colt. The current issue rifle at the time, the .30-40 Krag, had also failed to stop Moro warriors effectively; the British had similar issues switching to the .303 British, which resulted in the development of the dum-dum bullet. This experience, and the Thompson–LaGarde Tests of 1904 led the Army and the Cavalry, to decide a minimum of .45 caliber was required in the new handgun. Thompson and Major Louis Anatole La Garde of the Medical Corps arranged tests on cadavers and animal remains in the Chicago stockyards, resulting in the finding that .45 was the most effective pistol cartridge. They noted, however, training was critical to make sure a soldier could score a hit in a vulnerable part of the body.